Myeloma-bone marrow adipocyte axis in tumour survival and treatment response

Abbas Jafari*, Heather Fairfield, Thomas L. Andersen, Michaela R. Reagan

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Abstrakt

Multiple myeloma is an incurable cancer of the bone marrow that is dependent on its microenvironment, including bone marrow adipocytes (BMAds). Here, we discuss our findings that the reciprocal interaction of myeloma cells and BMAds, leads to myeloma cell survival and induces metabolic dysfunction and senescence-associated secretory phenotype in BMAds.

OriginalsprogEngelsk
TidsskriftBritish Journal of Cancer
Vol/bind125
Udgave nummer6
Sider (fra-til)775-777
ISSN0007-0920
DOI
StatusUdgivet - sep. 2021

Bibliografisk note

Funding Information:
Funding information T.L.A. had received funding from the Region of Southern Denmark (20/14282). M.R.R. had received funding from the American Cancer Society (Research Grant #RSG-19-037-01-LIB), the NIH (U54GM115516, R01AR049069, R37CA245330, and P20GM121301) and the Kane Foundation.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Cancer Research UK.

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