Myc protein overexpression is a feature of progression and adverse prognosis in multiple myeloma

Hanne E.H. Møller*, Birgitte S. Preiss, Per Pedersen, Brian Østergaard, Mikael Frederiksen, Niels Abildgaard, Michael B. Møller

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Abstrakt

Objective: Prognostic and predictive markers in multiple myeloma are continuously explored because of the heterogeneity of the tumor biology. Myc protein is the final product from activating MYC oncogene, but the prognostic impact in multiple myeloma is not well described. Methods: In a population-based cohort of 194 untreated, newly diagnosed patients with multiple myeloma, we assessed myc protein expression using CD138/myc immunohistochemical double stain and collected clinicopathological data. Results: Cases with myc protein expression ≥40% (mycHIGH) had a median overall survival of 11 months compared to 48 months in cases of myc protein expression <40% (mycLOW) (P < 0.01). MycHIGH was significantly correlated to R-ISS, high proliferation index, high percentage of plasma cell in bone marrow, plasmablastic morphology, high calcium level, and abnormal karyotype. In multivariate survival analyses, mycHIGH was independently associated with inferior overall survival with a hazard ratio of 2.5. Conclusion: Our results indicate myc protein overexpression to be associated with advanced multiple myeloma and poor prognosis.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Haematology
Vol/bind101
Udgave nummer5
Sider (fra-til)585-590
ISSN0902-4441
DOI
StatusUdgivet - 2018

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