Mural thrombus and the progression of abdominal aortic aneurysms

a large population-based prospective cohort study

C Behr-Rasmussen, N Grøndal, M B Bramsen, M D Thomsen, J S Lindholt

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE: To investigate whether the relative size of intraluminal thrombus (ILT) in abdominal aortic aneurysms (AAAs) is associated with AAA growth.

METHODS: This large observational study was based on a randomised population-based screening trial. Six hundred and fifteen AAAs were diagnosed in men aged 65-74 years. The relative cross-sectional area covered by the mural thrombus was estimated by a semiautomatic method using ultrasound equipment to measure the area of the ellipses, and adapting the inner ellipse (IA) to the luminal border of the thrombus and the outer ellipse to the area inside the media border (OA). The relative thrombus area was then calculated as ((OA-IA)/OU) × 100%. Four hundred and sixteen of the patients with AAA were eligible for analysis.

RESULTS: The mean size of the AAA was 40.6 mm, and the mean observation time was 1.78 years. In the group with AAAs measuring 30-34 mm, 42% had ILT, with a mean relative size of 12% of the outer area. In the group with AAAs measuring >64 mm, the presence of ILT increased to 100%, with a mean relative size of 70% of the outer area. Univariate analysis showed relative ILT size, aortic diameter, smoking history, and diastolic blood pressure were significantly positively associated with growth rate, while the presence of diabetes mellitus was significantly negatively associated with growth rate. The relative ILT size remained significantly positively associated with the growth rate after a multivariate linear regression adjusting for potential confounders.

CONCLUSION: These findings suggest that ILT may play a part in the progression of AAAs.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Vascular and Endovascular Surgery
Vol/bind48
Udgave nummer3
Sider (fra-til)301-307
ISSN1078-5884
DOI
StatusUdgivet - 2014

Fingeraftryk

Abdominal Aortic Aneurysm
Cohort Studies
Prospective Studies
Population
Growth
Linear Models
Diabetes Mellitus
Smoking
History
Observation
Equipment and Supplies

Citer dette

@article{d36be00601164c78ba54c3a4f358cabb,
title = "Mural thrombus and the progression of abdominal aortic aneurysms: a large population-based prospective cohort study",
abstract = "OBJECTIVE: To investigate whether the relative size of intraluminal thrombus (ILT) in abdominal aortic aneurysms (AAAs) is associated with AAA growth.METHODS: This large observational study was based on a randomised population-based screening trial. Six hundred and fifteen AAAs were diagnosed in men aged 65-74 years. The relative cross-sectional area covered by the mural thrombus was estimated by a semiautomatic method using ultrasound equipment to measure the area of the ellipses, and adapting the inner ellipse (IA) to the luminal border of the thrombus and the outer ellipse to the area inside the media border (OA). The relative thrombus area was then calculated as ((OA-IA)/OU) × 100{\%}. Four hundred and sixteen of the patients with AAA were eligible for analysis.RESULTS: The mean size of the AAA was 40.6 mm, and the mean observation time was 1.78 years. In the group with AAAs measuring 30-34 mm, 42{\%} had ILT, with a mean relative size of 12{\%} of the outer area. In the group with AAAs measuring >64 mm, the presence of ILT increased to 100{\%}, with a mean relative size of 70{\%} of the outer area. Univariate analysis showed relative ILT size, aortic diameter, smoking history, and diastolic blood pressure were significantly positively associated with growth rate, while the presence of diabetes mellitus was significantly negatively associated with growth rate. The relative ILT size remained significantly positively associated with the growth rate after a multivariate linear regression adjusting for potential confounders.CONCLUSION: These findings suggest that ILT may play a part in the progression of AAAs.",
keywords = "Aged, Aortic Aneurysm, Abdominal, Denmark, Disease Progression, Humans, Male, Prospective Studies, Randomized Controlled Trials as Topic, Thrombosis",
author = "C Behr-Rasmussen and N Gr{\o}ndal and Bramsen, {M B} and Thomsen, {M D} and Lindholt, {J S}",
note = "Copyright {\circledC} 2014 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.",
year = "2014",
doi = "10.1016/j.ejvs.2014.05.014",
language = "English",
volume = "48",
pages = "301--307",
journal = "European Journal of Vascular and Endovascular Surgery",
issn = "1078-5884",
publisher = "Elsevier",
number = "3",

}

Mural thrombus and the progression of abdominal aortic aneurysms : a large population-based prospective cohort study. / Behr-Rasmussen, C; Grøndal, N; Bramsen, M B; Thomsen, M D; Lindholt, J S.

I: European Journal of Vascular and Endovascular Surgery, Bind 48, Nr. 3, 2014, s. 301-307.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Mural thrombus and the progression of abdominal aortic aneurysms

T2 - a large population-based prospective cohort study

AU - Behr-Rasmussen, C

AU - Grøndal, N

AU - Bramsen, M B

AU - Thomsen, M D

AU - Lindholt, J S

N1 - Copyright © 2014 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

PY - 2014

Y1 - 2014

N2 - OBJECTIVE: To investigate whether the relative size of intraluminal thrombus (ILT) in abdominal aortic aneurysms (AAAs) is associated with AAA growth.METHODS: This large observational study was based on a randomised population-based screening trial. Six hundred and fifteen AAAs were diagnosed in men aged 65-74 years. The relative cross-sectional area covered by the mural thrombus was estimated by a semiautomatic method using ultrasound equipment to measure the area of the ellipses, and adapting the inner ellipse (IA) to the luminal border of the thrombus and the outer ellipse to the area inside the media border (OA). The relative thrombus area was then calculated as ((OA-IA)/OU) × 100%. Four hundred and sixteen of the patients with AAA were eligible for analysis.RESULTS: The mean size of the AAA was 40.6 mm, and the mean observation time was 1.78 years. In the group with AAAs measuring 30-34 mm, 42% had ILT, with a mean relative size of 12% of the outer area. In the group with AAAs measuring >64 mm, the presence of ILT increased to 100%, with a mean relative size of 70% of the outer area. Univariate analysis showed relative ILT size, aortic diameter, smoking history, and diastolic blood pressure were significantly positively associated with growth rate, while the presence of diabetes mellitus was significantly negatively associated with growth rate. The relative ILT size remained significantly positively associated with the growth rate after a multivariate linear regression adjusting for potential confounders.CONCLUSION: These findings suggest that ILT may play a part in the progression of AAAs.

AB - OBJECTIVE: To investigate whether the relative size of intraluminal thrombus (ILT) in abdominal aortic aneurysms (AAAs) is associated with AAA growth.METHODS: This large observational study was based on a randomised population-based screening trial. Six hundred and fifteen AAAs were diagnosed in men aged 65-74 years. The relative cross-sectional area covered by the mural thrombus was estimated by a semiautomatic method using ultrasound equipment to measure the area of the ellipses, and adapting the inner ellipse (IA) to the luminal border of the thrombus and the outer ellipse to the area inside the media border (OA). The relative thrombus area was then calculated as ((OA-IA)/OU) × 100%. Four hundred and sixteen of the patients with AAA were eligible for analysis.RESULTS: The mean size of the AAA was 40.6 mm, and the mean observation time was 1.78 years. In the group with AAAs measuring 30-34 mm, 42% had ILT, with a mean relative size of 12% of the outer area. In the group with AAAs measuring >64 mm, the presence of ILT increased to 100%, with a mean relative size of 70% of the outer area. Univariate analysis showed relative ILT size, aortic diameter, smoking history, and diastolic blood pressure were significantly positively associated with growth rate, while the presence of diabetes mellitus was significantly negatively associated with growth rate. The relative ILT size remained significantly positively associated with the growth rate after a multivariate linear regression adjusting for potential confounders.CONCLUSION: These findings suggest that ILT may play a part in the progression of AAAs.

KW - Aged

KW - Aortic Aneurysm, Abdominal

KW - Denmark

KW - Disease Progression

KW - Humans

KW - Male

KW - Prospective Studies

KW - Randomized Controlled Trials as Topic

KW - Thrombosis

U2 - 10.1016/j.ejvs.2014.05.014

DO - 10.1016/j.ejvs.2014.05.014

M3 - Journal article

VL - 48

SP - 301

EP - 307

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

SN - 1078-5884

IS - 3

ER -