Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Understanding Society Scientific Group, Lifelines Cohort, COGENT-Kidney Consortium, EPIC-InterAct Consortium

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

83 Downloads (Pure)

Abstrakt

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind51
Udgave nummer4
Sider (fra-til)636-648
ISSN1061-4036
DOI
StatusUdgivet - apr. 2019

    Fingerprint

Citationsformater

Understanding Society Scientific Group, Lifelines Cohort, COGENT-Kidney Consortium, & EPIC-InterAct Consortium (2019). Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51(4), 636-648. https://doi.org/10.1038/s41588-019-0378-y