MtDNA T4216C variation in multiple sclerosis: a systematic review and meta-analysis

Sasan Andalib, Mohammadreza Emamhadi*, Shahrokh Yousefzadeh-Chabok, Arsalan Salari, Abdolhosein Emami Sigaroudi, Manouchehr Seyedi Vafaee

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

MtDNA T4216C variation has frequently been investigated in Multiple Sclerosis (MS) patients; nonetheless, controversy has existed about the evidence of association of this variation with susceptibility to MS. The present systematic review and meta-analysis converge the results of the preceding publications, pertaining to association of mtDNA T4216C variation with susceptibility to MS, into a common conclusion. A computerized literature search in English was carried out to retrieve relevant publications from which required data were extracted. Using a fixed effect model, pooled odds ratio (OR), 95 % confidence interval (95 % CI), and P value were calculated for association of mtDNA T4216C variation with susceptibility to MS. The pooled results showed that there was a significant association between mtDNA T4216C variation and MS (OR = 1.38, 95 % CI = 1.13–1.67, P = 0.001). The present systematic review and meta-analysis suggest that mtDNA T4216C variation is a contributory factor in susceptibility to MS.

OriginalsprogEngelsk
TidsskriftActa Neurologica Belgica
Vol/bind116
Udgave nummer4
Sider (fra-til)439-443
ISSN0300-9009
DOI
StatusUdgivet - 2016

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