Abstract
Alternative LC/MS-based quantification methods have been applied to measure the amounts, concentration, and plasma activity of chitotriosidase for various Gaucher disease patients. LC/MSE and LC/MRM-MS/MS-based quantification methods have both been applied to measure the concentration of plasma proteins in an untargeted and targeted fashion, respectively. The qualitative results of the LC/MSE experiments were used to direct the development of unique, non-interfered MRM transitions for chitotriosidase.
Originalsprog | Engelsk |
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Publikationsdato | 2009 |
Status | Udgivet - 2009 |
Udgivet eksternt | Ja |