MRM quantification of chitotriosidase in human plasma: Application Note

Richard Remko Sprenger, Catalin Doneanu, Jim Langridge, Hans Vissers, Hans Aerts

Publikation: AndetUdgivelser på nettet - Net-publikationForskning

Abstract

Alternative LC/MS-based quantification methods have been applied to measure the amounts, concentration, and plasma activity of chitotriosidase for various Gaucher disease patients. LC/MSE and LC/MRM-MS/MS-based quantification methods have both been applied to measure the concentration of plasma proteins in an untargeted and targeted fashion, respectively. The qualitative results of the LC/MSE experiments were used to direct the development of unique, non-interfered MRM transitions for chitotriosidase.
OriginalsprogEngelsk
Publikationsdato2009
StatusUdgivet - 2009
Udgivet eksterntJa

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