Mouse and Rat Models of Induction of Hepatic Fibrosis and Assessment of Portal Hypertension

Sabine Klein, Robert Schierwagen, Frank Erhard Uschner, Jonel Trebicka

Publikation: Kapitel i bog/rapport/konference-proceedingKapitel i bogForskningpeer review

Abstrakt

Portal hypertension either develops due to progressive liver fibrosis or is the consequence of vascular liver diseases such as portal vein thrombosis or non-cirrhotic portal hypertension. This chapter focuses on different rodent models of liver fibrosis with portal hypertension and also in few non-cirrhotic portal hypertension models. Importantly, after the development of portal hypertension, the proper assessment of drug effects in the portal and systemic circulation should be discussed. The last part of the chapter is dedicated in these techniques to assess the in vivo hemodynamics and the ex vivo techniques of the isolated liver perfusion and vascular contractility.

OriginalsprogEngelsk
TitelFibrosis : Methods and Protocols
RedaktørerLaure Rittie
ForlagHumana Press
Publikationsdato2017
Sider91-116
Kapitel7
ISBN (Trykt)978-1-4939-7112-1
ISBN (Elektronisk)978-1-4939-7113-8
DOI
StatusUdgivet - 2017
Udgivet eksterntJa
NavnMethods in Molecular Biology
Vol/bind1627
ISSN1064-3745

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