Mortality in individuals with disruptive behavior disorders diagnosed by specialist services – A nationwide cohort study

James G. Scott*, Marianne Giørtz Pedersen, Holly E. Erskine, Aida Bikic, Ditte Demontis, John Joseph McGrath, Søren Dalsgaard

*Kontaktforfatter for dette arbejde

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Resumé

Disruptive behavior disorders (DBDs), inclusive of oppositional defiant disorder (ODD) and conduct disorder (CD), are associated with outcomes likely to increase risk of mortality. Using Danish National Registers, a total of 1.92 million individuals including 9495 individuals with DBDs diagnosed by specialist services were followed from their first birthday to 2013. Those with and without DBDs were compared using mortality rate ratios (MRRs) estimated using Poisson regression and adjusted for calendar period, age, sex, family history of psychiatric disorders, maternal age at time of birth, paternal age at time of birth, parental education status, and parental employment status. Over the course of follow up, which totalled 24.9 million person-years, 5580 cohort members died including 78 individuals with DBDs. The mortality rate per 10,000 person-years was 9.66 for individuals with DBDs compared to 2.22 for those with no diagnosis. This corresponded to a fully adjusted MRR of 2.57 (95% confidence interval 2.04–3.20). Comorbid substance use disorder and attention-deficit/hyperactivity disorder resulted in the highest MRR across all categories. These findings demonstrate the excess mortality associated with DBDs.

OriginalsprogEngelsk
TidsskriftPsychiatry Research
Vol/bind251
Sider (fra-til)255-260
ISSN0165-1781
DOI
StatusUdgivet - 2017

Fingeraftryk

Cohort Studies
Paternal Age
Conduct Disorder
Maternal Age
Confidence Intervals
Education

Citer dette

Scott, James G. ; Giørtz Pedersen, Marianne ; Erskine, Holly E. ; Bikic, Aida ; Demontis, Ditte ; McGrath, John Joseph ; Dalsgaard, Søren. / Mortality in individuals with disruptive behavior disorders diagnosed by specialist services – A nationwide cohort study. I: Psychiatry Research. 2017 ; Bind 251. s. 255-260.
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abstract = "Disruptive behavior disorders (DBDs), inclusive of oppositional defiant disorder (ODD) and conduct disorder (CD), are associated with outcomes likely to increase risk of mortality. Using Danish National Registers, a total of 1.92 million individuals including 9495 individuals with DBDs diagnosed by specialist services were followed from their first birthday to 2013. Those with and without DBDs were compared using mortality rate ratios (MRRs) estimated using Poisson regression and adjusted for calendar period, age, sex, family history of psychiatric disorders, maternal age at time of birth, paternal age at time of birth, parental education status, and parental employment status. Over the course of follow up, which totalled 24.9 million person-years, 5580 cohort members died including 78 individuals with DBDs. The mortality rate per 10,000 person-years was 9.66 for individuals with DBDs compared to 2.22 for those with no diagnosis. This corresponded to a fully adjusted MRR of 2.57 (95{\%} confidence interval 2.04–3.20). Comorbid substance use disorder and attention-deficit/hyperactivity disorder resulted in the highest MRR across all categories. These findings demonstrate the excess mortality associated with DBDs.",
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Mortality in individuals with disruptive behavior disorders diagnosed by specialist services – A nationwide cohort study. / Scott, James G.; Giørtz Pedersen, Marianne; Erskine, Holly E.; Bikic, Aida; Demontis, Ditte; McGrath, John Joseph; Dalsgaard, Søren.

I: Psychiatry Research, Bind 251, 2017, s. 255-260.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Mortality in individuals with disruptive behavior disorders diagnosed by specialist services – A nationwide cohort study

AU - Scott, James G.

AU - Giørtz Pedersen, Marianne

AU - Erskine, Holly E.

AU - Bikic, Aida

AU - Demontis, Ditte

AU - McGrath, John Joseph

AU - Dalsgaard, Søren

PY - 2017

Y1 - 2017

N2 - Disruptive behavior disorders (DBDs), inclusive of oppositional defiant disorder (ODD) and conduct disorder (CD), are associated with outcomes likely to increase risk of mortality. Using Danish National Registers, a total of 1.92 million individuals including 9495 individuals with DBDs diagnosed by specialist services were followed from their first birthday to 2013. Those with and without DBDs were compared using mortality rate ratios (MRRs) estimated using Poisson regression and adjusted for calendar period, age, sex, family history of psychiatric disorders, maternal age at time of birth, paternal age at time of birth, parental education status, and parental employment status. Over the course of follow up, which totalled 24.9 million person-years, 5580 cohort members died including 78 individuals with DBDs. The mortality rate per 10,000 person-years was 9.66 for individuals with DBDs compared to 2.22 for those with no diagnosis. This corresponded to a fully adjusted MRR of 2.57 (95% confidence interval 2.04–3.20). Comorbid substance use disorder and attention-deficit/hyperactivity disorder resulted in the highest MRR across all categories. These findings demonstrate the excess mortality associated with DBDs.

AB - Disruptive behavior disorders (DBDs), inclusive of oppositional defiant disorder (ODD) and conduct disorder (CD), are associated with outcomes likely to increase risk of mortality. Using Danish National Registers, a total of 1.92 million individuals including 9495 individuals with DBDs diagnosed by specialist services were followed from their first birthday to 2013. Those with and without DBDs were compared using mortality rate ratios (MRRs) estimated using Poisson regression and adjusted for calendar period, age, sex, family history of psychiatric disorders, maternal age at time of birth, paternal age at time of birth, parental education status, and parental employment status. Over the course of follow up, which totalled 24.9 million person-years, 5580 cohort members died including 78 individuals with DBDs. The mortality rate per 10,000 person-years was 9.66 for individuals with DBDs compared to 2.22 for those with no diagnosis. This corresponded to a fully adjusted MRR of 2.57 (95% confidence interval 2.04–3.20). Comorbid substance use disorder and attention-deficit/hyperactivity disorder resulted in the highest MRR across all categories. These findings demonstrate the excess mortality associated with DBDs.

KW - Conduct disorder

KW - Deaths

KW - Disruptive behavior disorders

KW - Epidemiology

KW - Mortality

KW - Oppositional defiant disorder

KW - Registries

U2 - 10.1016/j.psychres.2017.02.029

DO - 10.1016/j.psychres.2017.02.029

M3 - Journal article

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AN - SCOPUS:85013215583

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JO - Psychiatry Research

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SN - 0165-1781

ER -