Mortality and reinfarction among patients using different beta-blockers for secondary prevention after a myocardial infarction

Søren Skøtt Andersen, Morten Lock Hansen, Gunnar H Gislason, Fredrik Folke, Tina Ken Schramm, Emil Fosbøl, Rikke Sørensen, Søren Rasmussen, Steen Abildstrøm, Mette Madsen, Lars Køber, Christian Torp-Pedersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVES: To study differences in the clinical efficacy of various brands of beta-blocker in secondary prevention after a myocardial infarction (MI). METHODS: All patients hospitalized with a first MI between 1995 and 2002 who were still alive 30 days after discharge and had had at least one prescription for a beta-blocker filled were identified by individual-level linkage of nationwide registries of hospitalizations and drugs dispensed from pharmacies. A total of 32,259 MI patients were included in the study. Multivariable Cox proportional hazard models were used to analyze the risks of death and recurrent MI related to treatment with different beta-blockers. RESULTS: The risks for death and recurrent MI were similar in patients using different beta-blockers, except that mortality from all causes among patients with a prescription for sotalol was higher. Subgroup analyses of high-risk patients with diabetes or congestive heart failure and of patients using comparable dosages of beta-blockers did not show effects on the risk of death or recurrent MI. CONCLUSION: Except for sotalol, the different types of beta-blocker had similar clinical efficacy in reducing mortality and the recurrence of MI. The equivalent efficacy remained when high-risk patients were analyzed separately.
OriginalsprogEngelsk
TidsskriftCardiology
Vol/bind112
Udgave nummer2
Sider (fra-til)144-150
ISSN0008-6312
DOI
StatusUdgivet - 2009

Fingeraftryk

Prescriptions
Pharmacies
Proportional Hazards Models
Registries
Pharmaceutical Preparations

Citer dette

Andersen, S. S., Hansen, M. L., Gislason, G. H., Folke, F., Schramm, T. K., Fosbøl, E., ... Torp-Pedersen, C. (2009). Mortality and reinfarction among patients using different beta-blockers for secondary prevention after a myocardial infarction. Cardiology, 112(2), 144-150. https://doi.org/10.1159/000143389
Andersen, Søren Skøtt ; Hansen, Morten Lock ; Gislason, Gunnar H ; Folke, Fredrik ; Schramm, Tina Ken ; Fosbøl, Emil ; Sørensen, Rikke ; Rasmussen, Søren ; Abildstrøm, Steen ; Madsen, Mette ; Køber, Lars ; Torp-Pedersen, Christian. / Mortality and reinfarction among patients using different beta-blockers for secondary prevention after a myocardial infarction. I: Cardiology. 2009 ; Bind 112, Nr. 2. s. 144-150.
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title = "Mortality and reinfarction among patients using different beta-blockers for secondary prevention after a myocardial infarction",
abstract = "OBJECTIVES: To study differences in the clinical efficacy of various brands of beta-blocker in secondary prevention after a myocardial infarction (MI). METHODS: All patients hospitalized with a first MI between 1995 and 2002 who were still alive 30 days after discharge and had had at least one prescription for a beta-blocker filled were identified by individual-level linkage of nationwide registries of hospitalizations and drugs dispensed from pharmacies. A total of 32,259 MI patients were included in the study. Multivariable Cox proportional hazard models were used to analyze the risks of death and recurrent MI related to treatment with different beta-blockers. RESULTS: The risks for death and recurrent MI were similar in patients using different beta-blockers, except that mortality from all causes among patients with a prescription for sotalol was higher. Subgroup analyses of high-risk patients with diabetes or congestive heart failure and of patients using comparable dosages of beta-blockers did not show effects on the risk of death or recurrent MI. CONCLUSION: Except for sotalol, the different types of beta-blocker had similar clinical efficacy in reducing mortality and the recurrence of MI. The equivalent efficacy remained when high-risk patients were analyzed separately.",
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note = "Udgivelsesdato: 2009-null (c) 2008 S. Karger AG, Basel.",
year = "2009",
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Andersen, SS, Hansen, ML, Gislason, GH, Folke, F, Schramm, TK, Fosbøl, E, Sørensen, R, Rasmussen, S, Abildstrøm, S, Madsen, M, Køber, L & Torp-Pedersen, C 2009, 'Mortality and reinfarction among patients using different beta-blockers for secondary prevention after a myocardial infarction', Cardiology, bind 112, nr. 2, s. 144-150. https://doi.org/10.1159/000143389

Mortality and reinfarction among patients using different beta-blockers for secondary prevention after a myocardial infarction. / Andersen, Søren Skøtt; Hansen, Morten Lock; Gislason, Gunnar H; Folke, Fredrik; Schramm, Tina Ken; Fosbøl, Emil; Sørensen, Rikke; Rasmussen, Søren; Abildstrøm, Steen; Madsen, Mette; Køber, Lars; Torp-Pedersen, Christian.

I: Cardiology, Bind 112, Nr. 2, 2009, s. 144-150.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Mortality and reinfarction among patients using different beta-blockers for secondary prevention after a myocardial infarction

AU - Andersen, Søren Skøtt

AU - Hansen, Morten Lock

AU - Gislason, Gunnar H

AU - Folke, Fredrik

AU - Schramm, Tina Ken

AU - Fosbøl, Emil

AU - Sørensen, Rikke

AU - Rasmussen, Søren

AU - Abildstrøm, Steen

AU - Madsen, Mette

AU - Køber, Lars

AU - Torp-Pedersen, Christian

N1 - Udgivelsesdato: 2009-null (c) 2008 S. Karger AG, Basel.

PY - 2009

Y1 - 2009

N2 - OBJECTIVES: To study differences in the clinical efficacy of various brands of beta-blocker in secondary prevention after a myocardial infarction (MI). METHODS: All patients hospitalized with a first MI between 1995 and 2002 who were still alive 30 days after discharge and had had at least one prescription for a beta-blocker filled were identified by individual-level linkage of nationwide registries of hospitalizations and drugs dispensed from pharmacies. A total of 32,259 MI patients were included in the study. Multivariable Cox proportional hazard models were used to analyze the risks of death and recurrent MI related to treatment with different beta-blockers. RESULTS: The risks for death and recurrent MI were similar in patients using different beta-blockers, except that mortality from all causes among patients with a prescription for sotalol was higher. Subgroup analyses of high-risk patients with diabetes or congestive heart failure and of patients using comparable dosages of beta-blockers did not show effects on the risk of death or recurrent MI. CONCLUSION: Except for sotalol, the different types of beta-blocker had similar clinical efficacy in reducing mortality and the recurrence of MI. The equivalent efficacy remained when high-risk patients were analyzed separately.

AB - OBJECTIVES: To study differences in the clinical efficacy of various brands of beta-blocker in secondary prevention after a myocardial infarction (MI). METHODS: All patients hospitalized with a first MI between 1995 and 2002 who were still alive 30 days after discharge and had had at least one prescription for a beta-blocker filled were identified by individual-level linkage of nationwide registries of hospitalizations and drugs dispensed from pharmacies. A total of 32,259 MI patients were included in the study. Multivariable Cox proportional hazard models were used to analyze the risks of death and recurrent MI related to treatment with different beta-blockers. RESULTS: The risks for death and recurrent MI were similar in patients using different beta-blockers, except that mortality from all causes among patients with a prescription for sotalol was higher. Subgroup analyses of high-risk patients with diabetes or congestive heart failure and of patients using comparable dosages of beta-blockers did not show effects on the risk of death or recurrent MI. CONCLUSION: Except for sotalol, the different types of beta-blocker had similar clinical efficacy in reducing mortality and the recurrence of MI. The equivalent efficacy remained when high-risk patients were analyzed separately.

KW - Adrenergic beta-Antagonists

KW - Aged

KW - Atenolol

KW - Bisoprolol

KW - Female

KW - Humans

KW - Kaplan-Meiers Estimate

KW - Male

KW - Metoprolol

KW - Middle Aged

KW - Myocardial Infarction

KW - Proportional Hazards Models

KW - Recurrence

KW - Registries

KW - Sotalol

U2 - 10.1159/000143389

DO - 10.1159/000143389

M3 - Journal article

VL - 112

SP - 144

EP - 150

JO - Cardiology

JF - Cardiology

SN - 0008-6312

IS - 2

ER -