Molecular Profiling of Peripheral Blood Cells from Patients with Polycythemia Vera and Related Neoplasms: Identification of Deregulated Genes of Significance for Inflammation and Immune Surveillance

Vibe Skov, Thomas Stauffer Larsen, Mads Thomassen, Caroline H Riley, Morten K Jensen, Ole Weis Bjerrum, Torben A Kruse, Hans Carl Hasselbalch

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are haematopoietic stem cell neoplasms that may be associated with autoimmune or chronic inflammatory disorders. Earlier gene expression profiling studies have demonstrated aberrant expression of genes involved in inflammatory responses, mainly being performed on granulocytes or CD34+ cells.
Using gene expression profiling of whole blood from patients with ET (n=16), PV (n=36), and PMF (n=9), several genes involved in inflammation and immune regulation were found to be significantly deregulated. Our findings may reflect chronic inflammation to be of pathogenetic importance for the progression of these neoplasms towards the myelofibrotic end-stage and may also account for the increased frequency of second cancer in these diseases.
OriginalsprogEngelsk
TidsskriftLeukemia Research
Vol/bind36
Udgave nummer11
Sider (fra-til)1387-92
Antal sider6
ISSN0145-2126
StatusUdgivet - 2012

Citer dette

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title = "Molecular Profiling of Peripheral Blood Cells from Patients with Polycythemia Vera and Related Neoplasms: Identification of Deregulated Genes of Significance for Inflammation and Immune Surveillance",
abstract = "Essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are haematopoietic stem cell neoplasms that may be associated with autoimmune or chronic inflammatory disorders. Earlier gene expression profiling studies have demonstrated aberrant expression of genes involved in inflammatory responses, mainly being performed on granulocytes or CD34+ cells.Using gene expression profiling of whole blood from patients with ET (n=16), PV (n=36), and PMF (n=9), several genes involved in inflammation and immune regulation were found to be significantly deregulated. Our findings may reflect chronic inflammation to be of pathogenetic importance for the progression of these neoplasms towards the myelofibrotic end-stage and may also account for the increased frequency of second cancer in these diseases.",
author = "Vibe Skov and Larsen, {Thomas Stauffer} and Mads Thomassen and {H Riley}, Caroline and Jensen, {Morten K} and Bjerrum, {Ole Weis} and Kruse, {Torben A} and Hasselbalch, {Hans Carl}",
year = "2012",
language = "English",
volume = "36",
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journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Pergamon Press",
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}

Molecular Profiling of Peripheral Blood Cells from Patients with Polycythemia Vera and Related Neoplasms: Identification of Deregulated Genes of Significance for Inflammation and Immune Surveillance. / Skov, Vibe; Larsen, Thomas Stauffer; Thomassen, Mads; H Riley, Caroline; Jensen, Morten K; Bjerrum, Ole Weis; Kruse, Torben A; Hasselbalch, Hans Carl.

I: Leukemia Research, Bind 36, Nr. 11, 2012, s. 1387-92.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Molecular Profiling of Peripheral Blood Cells from Patients with Polycythemia Vera and Related Neoplasms: Identification of Deregulated Genes of Significance for Inflammation and Immune Surveillance

AU - Skov, Vibe

AU - Larsen, Thomas Stauffer

AU - Thomassen, Mads

AU - H Riley, Caroline

AU - Jensen, Morten K

AU - Bjerrum, Ole Weis

AU - Kruse, Torben A

AU - Hasselbalch, Hans Carl

PY - 2012

Y1 - 2012

N2 - Essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are haematopoietic stem cell neoplasms that may be associated with autoimmune or chronic inflammatory disorders. Earlier gene expression profiling studies have demonstrated aberrant expression of genes involved in inflammatory responses, mainly being performed on granulocytes or CD34+ cells.Using gene expression profiling of whole blood from patients with ET (n=16), PV (n=36), and PMF (n=9), several genes involved in inflammation and immune regulation were found to be significantly deregulated. Our findings may reflect chronic inflammation to be of pathogenetic importance for the progression of these neoplasms towards the myelofibrotic end-stage and may also account for the increased frequency of second cancer in these diseases.

AB - Essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are haematopoietic stem cell neoplasms that may be associated with autoimmune or chronic inflammatory disorders. Earlier gene expression profiling studies have demonstrated aberrant expression of genes involved in inflammatory responses, mainly being performed on granulocytes or CD34+ cells.Using gene expression profiling of whole blood from patients with ET (n=16), PV (n=36), and PMF (n=9), several genes involved in inflammation and immune regulation were found to be significantly deregulated. Our findings may reflect chronic inflammation to be of pathogenetic importance for the progression of these neoplasms towards the myelofibrotic end-stage and may also account for the increased frequency of second cancer in these diseases.

M3 - Journal article

VL - 36

SP - 1387

EP - 1392

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 11

ER -