Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

Susanne Mandrup, Anne Skovsø Bugge

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPARα, β/δ, and γ activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.
OriginalsprogEngelsk
Artikelnummer169506
TidsskriftP P A R Research
Vol/bind2010
Antal sider12
ISSN1687-4757
DOI
StatusUdgivet - 2010

Fingeraftryk

Transcriptional Activation
Energy Metabolism
Homeostasis
Fats

Citer dette

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abstract = "The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPARα, β/δ, and γ activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.",
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Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation. / Mandrup, Susanne; Bugge, Anne Skovsø.

I: P P A R Research, Bind 2010, 169506, 2010.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AB - The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPARα, β/δ, and γ activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.

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