Molecular design opportunities presented by solvent-exposed regions of target proteins

Xiangyi Jiang, Ji Yu, Zhongxia Zhou, Jacob Kongsted, Yuning Song, Christophe Pannecouque, Erik De Clercq, Dongwei Kang*, Vasanthanathan Poongavanam, Xinyong Liu, Peng Zhan

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Abstrakt

Solvent-exposed regions, or solvent-filled pockets, within or adjacent to the ligand-binding sites of drug-target proteins provide opportunities for substantial modifications of existing small-molecular drug molecules without serious loss of activity. In this review, we present recent selected examples of exploitation of solvent-exposed regions of proteins in drug design and development from the recent medicinal-chemistry literature.

OriginalsprogEngelsk
TidsskriftMedicinal Research Reviews
Vol/bind39
Udgave nummer6
Sider (fra-til)2194-2238
Antal sider45
ISSN0198-6325
DOI
StatusUdgivet - nov. 2019

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