Molecular characterization of clear cell renal cell carcinoma identifies CSNK2A1, SPP1 and DEFB1 as promising novel prognostic markers

Maj Rabjerg, Henriette Bjerregaard, Ulrich Halekoh, Boye L Jensen, Steen Walter, Niels Marcussen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

The prognosis associated with clear cell renal carcinoma (ccRCC) can vary widely and novel molecular prognostic markers are needed to assess prognosis at an earlier stage. Several gene products have been investigated for this purpose, but none of them have been implemented in clinical practice. Here we hypothesized that we, using TaqMan® Array, could identify superior prognostic messenger RNA (mRNA)s in long-term follow-up. Messenger RNA level of 19 candidate genes was investigated in 97 patients with ccRCC. Three genes impacted significantly on prognosis in both univariate and multivariate analysis. In univariate analysis, CSNK2A1 was a strong indicator of a poor overall survival (OS) (HR = 5.01, p < 0.001), disease specific survival (DSS) (HR = 6.21, p = 0.007) and progression free survival (PFS) (HR = 5.93, p = 0.005). High expression of SPP1 was associated to poor PFS (HR = 4.41, p = 0.04). DEFB1 was associated with a better PFS (HR = 0.24, p = 0.006). In multivariate analysis, CSNK2A1 was associated to a worse OS (HR = 3.56, p = 0.008) and PFS (HR = 3.84, p = 0.005), whereas SPP1 was an independent predictor of a worse PFS (HR = 3.46, p = 0.007) and DEFB1 of a better PFS (HR = 0.37, p = 0.027). These results show that with TaqMan® Array we could identify three superior gene products related to prognosis. Further studies are needed to elucidate the pathways and roles of these genes in renal cancer development.
OriginalsprogEngelsk
TidsskriftA P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Vol/bind124
Udgave nummer5
Sider (fra-til)372-383
ISSN0903-4641
DOI
StatusUdgivet - 1. maj 2016

Emneord

  • ccRCC
  • CSNK2A1
  • SPP1
  • DEFB1
  • prognosis
  • Taqman Array

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