Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

Jesper B Moeller, Irina Leonardi, Anders Schlosser, Anne-Laure Flamar, Nicholas J Bessman, Gregory Garbès Putzel, Theresa Thomsen, Mark Hammond, Christine S Jepsen, Karsten Skjødt, Ernst-Martin Füchtbauer, Donna L Farber, Grith L Sorensen, Iliyan D Iliev, Uffe Holmskov, David Artis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

10 Downloads (Pure)


Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.

TidsskriftThe Journal of Experimental Medicine
Udgave nummer12
Sider (fra-til)2689-2700
StatusUdgivet - 10. okt. 2019

Bibliografisk note

© 2019 Moeller et al.

Fingeraftryk Dyk ned i forskningsemnerne om 'Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1'. Sammen danner de et unikt fingeraftryk.