Modulation of chromatin access during adipocyte differentiation

Susanne Mandrup, Gordon L Hager

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Cellular development requires reprogramming of the genome to modulate the gene program of the undifferentiated cell and allow expression of the gene program unique to differentiated cells. A number of key transcription factors involved in this reprogramming of preadipocytes to adipocytes have been identified; however, it is not until recently that we have begun to understand how these factors act at a genome-wide scale. In a recent publication we have mapped the genome-wide changes in chromatin structure during differentiation of 3T3-L1 preadipocytes and shown that a major reorganization of the chromatin landscape occurs within few hours following the addition of the adipogenic cocktail. In addition, we have mapped the genome-wide profiles of several of the early adipogenic transcription factors and shown that they act in a highly cooperative manner to drive this dramatic remodeling process.
OriginalsprogEngelsk
TidsskriftNucleus (Austin)
Vol/bind3
Udgave nummer1
Sider (fra-til)12-15
Antal sider4
ISSN1949-1034
DOI
StatusUdgivet - 2012

Fingeraftryk

Adipocytes

Citer dette

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Modulation of chromatin access during adipocyte differentiation. / Mandrup, Susanne; Hager, Gordon L.

I: Nucleus (Austin), Bind 3, Nr. 1, 2012, s. 12-15.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Modulation of chromatin access during adipocyte differentiation

AU - Mandrup, Susanne

AU - Hager, Gordon L

PY - 2012

Y1 - 2012

N2 - Cellular development requires reprogramming of the genome to modulate the gene program of the undifferentiated cell and allow expression of the gene program unique to differentiated cells. A number of key transcription factors involved in this reprogramming of preadipocytes to adipocytes have been identified; however, it is not until recently that we have begun to understand how these factors act at a genome-wide scale. In a recent publication we have mapped the genome-wide changes in chromatin structure during differentiation of 3T3-L1 preadipocytes and shown that a major reorganization of the chromatin landscape occurs within few hours following the addition of the adipogenic cocktail. In addition, we have mapped the genome-wide profiles of several of the early adipogenic transcription factors and shown that they act in a highly cooperative manner to drive this dramatic remodeling process.

AB - Cellular development requires reprogramming of the genome to modulate the gene program of the undifferentiated cell and allow expression of the gene program unique to differentiated cells. A number of key transcription factors involved in this reprogramming of preadipocytes to adipocytes have been identified; however, it is not until recently that we have begun to understand how these factors act at a genome-wide scale. In a recent publication we have mapped the genome-wide changes in chromatin structure during differentiation of 3T3-L1 preadipocytes and shown that a major reorganization of the chromatin landscape occurs within few hours following the addition of the adipogenic cocktail. In addition, we have mapped the genome-wide profiles of several of the early adipogenic transcription factors and shown that they act in a highly cooperative manner to drive this dramatic remodeling process.

U2 - 10.4161/nucl.18928

DO - 10.4161/nucl.18928

M3 - Journal article

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JO - Nucleus (Austin)

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