Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

Maria Ejlersen, Chenguang Lou, Yogesh S. Sanghvi, Yitzhak Tor, Jesper Wengel*

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Abstrakt

The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides containing one or more 2′-deoxy-5-iodouridine (5IdU) monomer(s) or on oligonucleotide fragments immediately after incorporation of 5IdU. Five different functionalities were coupled to oligonucleotides containing one or three attachment points.

OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind54
Udgave nummer57
Sider (fra-til)8003-8006
ISSN1359-7345
DOI
StatusUdgivet - 12. jul. 2018

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