Modest implication of interleukin-6 promoter polymorphisms in longevity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: May
OriginalsprogEngelsk
TidsskriftMechanisms of Ageing and Development
Vol/bind125
Udgave nummer5
Sider (fra-til)391-395
ISSN0047-6374
DOI
StatusUdgivet - 1. maj 2004

Fingeraftryk

Interleukin-6
Homozygote
Haplotypes

Citer dette

@article{0c2b6bc0ecf011db821c000ea68e967b,
title = "Modest implication of interleukin-6 promoter polymorphisms in longevity",
abstract = "The multifunctional interleukin-6 has been suggested to contribute to a chronic low-grade inflammatory status, thereby conferring susceptibility to age-related pathological conditions as well as functional decline and increased mortality.Several polymorphisms have been identified in the interleukin-6 promoter, but investigation of the effect of these on interleukin-6 levels and disease susceptibility have led to contradictory results.This study investigates the significance of the three single-point polymorphisms (−597G/A, −572G/C and −174G/C) and the AT-stretch polymorphism (−373(A)n(T)m) in ageing, by comparison of the frequency of each single polymorphism separately as well as the entire promoter haplotype in a total of 1710 Danish subjects ranging in age from 47 to 100 years.We found a modest, but significant, increase in the frequency of interleukin-6 −174GG homozygotes with age suggesting that this genotype is advantageous for longevity.",
author = "Lene Christiansen and Lise Bathum and Karen Andersen-Ranberg and Bernard Jeune and Kaare Christensen",
year = "2004",
month = "5",
day = "1",
doi = "10.1016/j.mad.2004.03.004",
language = "English",
volume = "125",
pages = "391--395",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier",
number = "5",

}

Modest implication of interleukin-6 promoter polymorphisms in longevity. / Christiansen, Lene; Bathum, Lise; Andersen-Ranberg, Karen; Jeune, Bernard; Christensen, Kaare.

I: Mechanisms of Ageing and Development, Bind 125, Nr. 5, 01.05.2004, s. 391-395.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Modest implication of interleukin-6 promoter polymorphisms in longevity

AU - Christiansen, Lene

AU - Bathum, Lise

AU - Andersen-Ranberg, Karen

AU - Jeune, Bernard

AU - Christensen, Kaare

PY - 2004/5/1

Y1 - 2004/5/1

N2 - The multifunctional interleukin-6 has been suggested to contribute to a chronic low-grade inflammatory status, thereby conferring susceptibility to age-related pathological conditions as well as functional decline and increased mortality.Several polymorphisms have been identified in the interleukin-6 promoter, but investigation of the effect of these on interleukin-6 levels and disease susceptibility have led to contradictory results.This study investigates the significance of the three single-point polymorphisms (−597G/A, −572G/C and −174G/C) and the AT-stretch polymorphism (−373(A)n(T)m) in ageing, by comparison of the frequency of each single polymorphism separately as well as the entire promoter haplotype in a total of 1710 Danish subjects ranging in age from 47 to 100 years.We found a modest, but significant, increase in the frequency of interleukin-6 −174GG homozygotes with age suggesting that this genotype is advantageous for longevity.

AB - The multifunctional interleukin-6 has been suggested to contribute to a chronic low-grade inflammatory status, thereby conferring susceptibility to age-related pathological conditions as well as functional decline and increased mortality.Several polymorphisms have been identified in the interleukin-6 promoter, but investigation of the effect of these on interleukin-6 levels and disease susceptibility have led to contradictory results.This study investigates the significance of the three single-point polymorphisms (−597G/A, −572G/C and −174G/C) and the AT-stretch polymorphism (−373(A)n(T)m) in ageing, by comparison of the frequency of each single polymorphism separately as well as the entire promoter haplotype in a total of 1710 Danish subjects ranging in age from 47 to 100 years.We found a modest, but significant, increase in the frequency of interleukin-6 −174GG homozygotes with age suggesting that this genotype is advantageous for longevity.

U2 - 10.1016/j.mad.2004.03.004

DO - 10.1016/j.mad.2004.03.004

M3 - Journal article

VL - 125

SP - 391

EP - 395

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - 5

ER -