Renewable aviation fuel is the most promising alternative to reduce emissions in the aviation sector; its production is technically feasible, but not its cost respect to fossil jet fuel. Then, novel pathways need to be developed. One option is the processing through a biorefinery scheme, where biomass is completely converted to several products. Thus, in this work the computer-aided design and analysis of an integrated biorefinery for the conversion of Jatropha curcas fruit, castor bean plant, microalgae biomass and cooking oil is presented; the biorefinery is planned to produce aviation biofuel and other biofuels. The conversion processes are modelled and simulated using Aspen Plus. The assessment of the biorefinery is realized through the estimation of total annual cost, released CO
2 emissions, and the net gross profit. Results indicated that biojet fuel represents 33% of net gross profit, with 5.52 kW invested per kW of energy delivered by the products.