Mobile phones and multiple sclerosis--a nationwide cohort study in Denmark

Aslak Harbo Poulsen, Egon Stenager, Christoffer Johansen, Joan Bentzen, Søren Friis, Joachim Schüz

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We investigated the risk of, prognosis of and symptoms of multiple sclerosis (MS) among all Danish residents who owned a mobile phone subscription before 1996. Using the Danish Multiple Sclerosis Registry and Civil Registration System, study subjects were followed up for MS through 2004. Poisson models were used to calculate incidence rate ratios (IRR, age range: 18-64 years) and mortality rate ratios (MRR, age range: 18+) and to compare presenting symptoms among subscribers and all non-subscribers. A total of 405 971 subscription holders accrued four million years of follow up, with men accounting for 86% of the observation time. Among subscription holding men, the IRR of MS was close to unity, overall as well as 13+ years after first subscription (IRR 1.02, 95% CI: 0.48-2.16). Among women, the IRR was 3.43 (95% CI: 0.86-13.72) 13+ years after first subscription, however, based on only two cases. Presenting symptoms of MS differed between subscribers and non-subscribers (p = 0.03), with slightly increased risk of diplopia in both genders (IRR: 1.38, 95% CI: 1.02-1.86), an increased risk of fatigue among women (IRR: 3.02, 95% CI: 1.45-6.28), and of optic neuritis among men (IRR: 1.38, 95% CI: 1.03-1.86). Overall the MRR was close to one (MRR: 0.91, 95%CI 0.70-1.19) among MS-patients with a subscription and although we observed some increased MRR estimates among women, these were based on small numbers. In conclusion, we found little evidence for a pronounced association between mobile phone use and risk of MS or mortality rate among MS patients. Symptoms of MS differed between subscribers and nonsubscribers for symptoms previously suggested to be associated with mobile phone use. This deserves further attention, as does the increased long-term risk of MS among female subscribers, although small numbers and lack of consistency between genders prevent causal interpretation.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind7
Udgave nummer4
Sider (fra-til)e34453
ISSN1932-6203
DOI
StatusUdgivet - 2012

Fingeraftryk

sclerosis
Denmark
cohort studies
Mobile phones
Cohort Studies
signs and symptoms (animals and humans)
insulin receptor-related receptor
Optic Neuritis
Optics
Diplopia
gender
Fatigue of materials
optics
prognosis
Registries
Observation
incidence
Incidence

Citer dette

Harbo Poulsen, A., Stenager, E., Johansen, C., Bentzen, J., Friis, S., & Schüz, J. (2012). Mobile phones and multiple sclerosis--a nationwide cohort study in Denmark. P L o S One, 7(4), e34453. https://doi.org/10.1371/journal.pone.0034453
Harbo Poulsen, Aslak ; Stenager, Egon ; Johansen, Christoffer ; Bentzen, Joan ; Friis, Søren ; Schüz, Joachim. / Mobile phones and multiple sclerosis--a nationwide cohort study in Denmark. I: P L o S One. 2012 ; Bind 7, Nr. 4. s. e34453.
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abstract = "We investigated the risk of, prognosis of and symptoms of multiple sclerosis (MS) among all Danish residents who owned a mobile phone subscription before 1996. Using the Danish Multiple Sclerosis Registry and Civil Registration System, study subjects were followed up for MS through 2004. Poisson models were used to calculate incidence rate ratios (IRR, age range: 18-64 years) and mortality rate ratios (MRR, age range: 18+) and to compare presenting symptoms among subscribers and all non-subscribers. A total of 405 971 subscription holders accrued four million years of follow up, with men accounting for 86{\%} of the observation time. Among subscription holding men, the IRR of MS was close to unity, overall as well as 13+ years after first subscription (IRR 1.02, 95{\%} CI: 0.48-2.16). Among women, the IRR was 3.43 (95{\%} CI: 0.86-13.72) 13+ years after first subscription, however, based on only two cases. Presenting symptoms of MS differed between subscribers and non-subscribers (p = 0.03), with slightly increased risk of diplopia in both genders (IRR: 1.38, 95{\%} CI: 1.02-1.86), an increased risk of fatigue among women (IRR: 3.02, 95{\%} CI: 1.45-6.28), and of optic neuritis among men (IRR: 1.38, 95{\%} CI: 1.03-1.86). Overall the MRR was close to one (MRR: 0.91, 95{\%}CI 0.70-1.19) among MS-patients with a subscription and although we observed some increased MRR estimates among women, these were based on small numbers. In conclusion, we found little evidence for a pronounced association between mobile phone use and risk of MS or mortality rate among MS patients. Symptoms of MS differed between subscribers and nonsubscribers for symptoms previously suggested to be associated with mobile phone use. This deserves further attention, as does the increased long-term risk of MS among female subscribers, although small numbers and lack of consistency between genders prevent causal interpretation.",
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Harbo Poulsen, A, Stenager, E, Johansen, C, Bentzen, J, Friis, S & Schüz, J 2012, 'Mobile phones and multiple sclerosis--a nationwide cohort study in Denmark', P L o S One, bind 7, nr. 4, s. e34453. https://doi.org/10.1371/journal.pone.0034453

Mobile phones and multiple sclerosis--a nationwide cohort study in Denmark. / Harbo Poulsen, Aslak; Stenager, Egon; Johansen, Christoffer; Bentzen, Joan; Friis, Søren; Schüz, Joachim.

I: P L o S One, Bind 7, Nr. 4, 2012, s. e34453.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Mobile phones and multiple sclerosis--a nationwide cohort study in Denmark

AU - Harbo Poulsen, Aslak

AU - Stenager, Egon

AU - Johansen, Christoffer

AU - Bentzen, Joan

AU - Friis, Søren

AU - Schüz, Joachim

PY - 2012

Y1 - 2012

N2 - We investigated the risk of, prognosis of and symptoms of multiple sclerosis (MS) among all Danish residents who owned a mobile phone subscription before 1996. Using the Danish Multiple Sclerosis Registry and Civil Registration System, study subjects were followed up for MS through 2004. Poisson models were used to calculate incidence rate ratios (IRR, age range: 18-64 years) and mortality rate ratios (MRR, age range: 18+) and to compare presenting symptoms among subscribers and all non-subscribers. A total of 405 971 subscription holders accrued four million years of follow up, with men accounting for 86% of the observation time. Among subscription holding men, the IRR of MS was close to unity, overall as well as 13+ years after first subscription (IRR 1.02, 95% CI: 0.48-2.16). Among women, the IRR was 3.43 (95% CI: 0.86-13.72) 13+ years after first subscription, however, based on only two cases. Presenting symptoms of MS differed between subscribers and non-subscribers (p = 0.03), with slightly increased risk of diplopia in both genders (IRR: 1.38, 95% CI: 1.02-1.86), an increased risk of fatigue among women (IRR: 3.02, 95% CI: 1.45-6.28), and of optic neuritis among men (IRR: 1.38, 95% CI: 1.03-1.86). Overall the MRR was close to one (MRR: 0.91, 95%CI 0.70-1.19) among MS-patients with a subscription and although we observed some increased MRR estimates among women, these were based on small numbers. In conclusion, we found little evidence for a pronounced association between mobile phone use and risk of MS or mortality rate among MS patients. Symptoms of MS differed between subscribers and nonsubscribers for symptoms previously suggested to be associated with mobile phone use. This deserves further attention, as does the increased long-term risk of MS among female subscribers, although small numbers and lack of consistency between genders prevent causal interpretation.

AB - We investigated the risk of, prognosis of and symptoms of multiple sclerosis (MS) among all Danish residents who owned a mobile phone subscription before 1996. Using the Danish Multiple Sclerosis Registry and Civil Registration System, study subjects were followed up for MS through 2004. Poisson models were used to calculate incidence rate ratios (IRR, age range: 18-64 years) and mortality rate ratios (MRR, age range: 18+) and to compare presenting symptoms among subscribers and all non-subscribers. A total of 405 971 subscription holders accrued four million years of follow up, with men accounting for 86% of the observation time. Among subscription holding men, the IRR of MS was close to unity, overall as well as 13+ years after first subscription (IRR 1.02, 95% CI: 0.48-2.16). Among women, the IRR was 3.43 (95% CI: 0.86-13.72) 13+ years after first subscription, however, based on only two cases. Presenting symptoms of MS differed between subscribers and non-subscribers (p = 0.03), with slightly increased risk of diplopia in both genders (IRR: 1.38, 95% CI: 1.02-1.86), an increased risk of fatigue among women (IRR: 3.02, 95% CI: 1.45-6.28), and of optic neuritis among men (IRR: 1.38, 95% CI: 1.03-1.86). Overall the MRR was close to one (MRR: 0.91, 95%CI 0.70-1.19) among MS-patients with a subscription and although we observed some increased MRR estimates among women, these were based on small numbers. In conclusion, we found little evidence for a pronounced association between mobile phone use and risk of MS or mortality rate among MS patients. Symptoms of MS differed between subscribers and nonsubscribers for symptoms previously suggested to be associated with mobile phone use. This deserves further attention, as does the increased long-term risk of MS among female subscribers, although small numbers and lack of consistency between genders prevent causal interpretation.

KW - Cellular Phone

KW - Denmark

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Multiple Sclerosis

KW - Regression Analysis

KW - Risk Factors

U2 - 10.1371/journal.pone.0034453

DO - 10.1371/journal.pone.0034453

M3 - Journal article

C2 - 22558088

VL - 7

SP - e34453

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 4

ER -