MMP mediated degradation of type VI collagen is highly associated with liver fibrosis-identification and validation of a novel biochemical marker assay

Sanne Skovgård Veidal, Morten Asser Karsdal, Efstathios Vassiliadis, Arkadiusz Nawrocki, Martin Røssel Larsen, Quoc Hai Trieu Nguyen, Per Hägglund, Yunyun Luo, Qinlong Zheng, Ben Vainer, Diana Julie Leeming

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

During fibrogenesis, in which excessive remodeling of the extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix metalloproteinases, including MMP-2 and MMP-9, increase significantly. Proteolytic degradation of type VI collagen into small fragments, so-called neo-epitopes, may be specific biochemical marker of liver fibrosis. The aim of this study was to develop an ELISA detecting a fragment of type VI collagen generated by MMP-2 and MMP-9, and evaluate this assay in two preclinical models of liver fibrosis.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind6
Udgave nummer9
Sider (fra-til)e24753
ISSN1932-6203
DOI
StatusUdgivet - 1. jan. 2011

Fingeraftryk

Dyk ned i forskningsemnerne om 'MMP mediated degradation of type VI collagen is highly associated with liver fibrosis-identification and validation of a novel biochemical marker assay'. Sammen danner de et unikt fingeraftryk.

Citationsformater