Mitochondrial membranes with mono- and divalent salt: changes induced by salt ions on structure and dynamics

Sanja Pöyry, Tomasz Róg, Mikko Karttunen, Ilpo Vattulainen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Nov-26
OriginalsprogEngelsk
TidsskriftJournal of Physical Chemistry B
Vol/bind113
Udgave nummer47
Sider (fra-til)15513-21
Antal sider8
ISSN1520-6106
DOI
StatusUdgivet - 26. nov. 2009

Fingeraftryk

Lipids
lipids
Salts
Ions
membranes
salts
Membranes
ions
Mitochondria
Cardiolipins
mitochondria
dynamic characteristics
Structural properties
Electrostatics
electrostatics
simulation
interactions

Citer dette

Pöyry, Sanja ; Róg, Tomasz ; Karttunen, Mikko ; Vattulainen, Ilpo. / Mitochondrial membranes with mono- and divalent salt: changes induced by salt ions on structure and dynamics. I: Journal of Physical Chemistry B. 2009 ; Bind 113, Nr. 47. s. 15513-21.
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title = "Mitochondrial membranes with mono- and divalent salt: changes induced by salt ions on structure and dynamics",
abstract = "We employ atomistic simulations to consider how mono- (NaCl) and divalent (CaCl(2)) salt affects properties of inner and outer membranes of mitochondria. We find that the influence of salt on structural properties is rather minute, only weakly affecting lipid packing, conformational ordering, and membrane electrostatic potential. The changes induced by salt are more prominent in dynamical properties related to ion binding and formation of ion-lipid complexes and lipid aggregates, as rotational diffusion of lipids is slowed down by ions, especially in the case of CaCl(2). In the same spirit, lateral diffusion of lipids is slowed down rather considerably for increasing concentration of CaCl(2). Both findings for dynamic properties can be traced to the binding of ions with lipid head groups and the related changes in interaction patterns in the headgroup region, where the binding of Na(+) and Ca(2+) ions is clearly different. The role of cardiolipins in these phenomena turns out to be important.",
keywords = "Calcium Chloride, Cardiolipins, Cations, Divalent, Cations, Monovalent, Diffusion, Membrane Potentials, Mitochondrial Membranes, Molecular Dynamics Simulation, Protein Binding, Sodium Chloride, Static Electricity",
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Mitochondrial membranes with mono- and divalent salt: changes induced by salt ions on structure and dynamics. / Pöyry, Sanja; Róg, Tomasz; Karttunen, Mikko; Vattulainen, Ilpo.

I: Journal of Physical Chemistry B, Bind 113, Nr. 47, 26.11.2009, s. 15513-21.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Mitochondrial membranes with mono- and divalent salt: changes induced by salt ions on structure and dynamics

AU - Pöyry, Sanja

AU - Róg, Tomasz

AU - Karttunen, Mikko

AU - Vattulainen, Ilpo

PY - 2009/11/26

Y1 - 2009/11/26

N2 - We employ atomistic simulations to consider how mono- (NaCl) and divalent (CaCl(2)) salt affects properties of inner and outer membranes of mitochondria. We find that the influence of salt on structural properties is rather minute, only weakly affecting lipid packing, conformational ordering, and membrane electrostatic potential. The changes induced by salt are more prominent in dynamical properties related to ion binding and formation of ion-lipid complexes and lipid aggregates, as rotational diffusion of lipids is slowed down by ions, especially in the case of CaCl(2). In the same spirit, lateral diffusion of lipids is slowed down rather considerably for increasing concentration of CaCl(2). Both findings for dynamic properties can be traced to the binding of ions with lipid head groups and the related changes in interaction patterns in the headgroup region, where the binding of Na(+) and Ca(2+) ions is clearly different. The role of cardiolipins in these phenomena turns out to be important.

AB - We employ atomistic simulations to consider how mono- (NaCl) and divalent (CaCl(2)) salt affects properties of inner and outer membranes of mitochondria. We find that the influence of salt on structural properties is rather minute, only weakly affecting lipid packing, conformational ordering, and membrane electrostatic potential. The changes induced by salt are more prominent in dynamical properties related to ion binding and formation of ion-lipid complexes and lipid aggregates, as rotational diffusion of lipids is slowed down by ions, especially in the case of CaCl(2). In the same spirit, lateral diffusion of lipids is slowed down rather considerably for increasing concentration of CaCl(2). Both findings for dynamic properties can be traced to the binding of ions with lipid head groups and the related changes in interaction patterns in the headgroup region, where the binding of Na(+) and Ca(2+) ions is clearly different. The role of cardiolipins in these phenomena turns out to be important.

KW - Calcium Chloride

KW - Cardiolipins

KW - Cations, Divalent

KW - Cations, Monovalent

KW - Diffusion

KW - Membrane Potentials

KW - Mitochondrial Membranes

KW - Molecular Dynamics Simulation

KW - Protein Binding

KW - Sodium Chloride

KW - Static Electricity

U2 - 10.1021/jp905915m

DO - 10.1021/jp905915m

M3 - Journal article

C2 - 19886603

VL - 113

SP - 15513

EP - 15521

JO - Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical

JF - Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical

SN - 1520-6106

IS - 47

ER -