Mitochondrial dynamics and proteins related to neurodegenerative diseases

A. Alexiou, B. Nizami, F.I. Khan, G. Soursou, C. Vairaktarakis, S. Chatzichronis, V. Tsiamis, V. Manztavinos, N.S. Yarla, G. Md Ashraf

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Abstrakt

Disruptions in the regulation of mitochondrial dynamics and the occurrence of proteins misfolding lead to neuronal death, resulting in Age-related Dementia and Neurodegenerative diseases as well as Frailty. Functional, neurophysiologic and biochemical alterations within the mitochondrial populations can reveal deficits in brain energy metabolism resulting in Mild Cognitive Impairment, abnormal neural development, autonomic dysfunction and other mitochondrial disorders. Additionally, in cases of Alzheimer’s disease or Parkinson’s disease, a significant number of proteins seem to form unordered and problematic structures, leading through unknown mechanisms to pathological conditions. While the proteins structure prediction problem is still an open challenge regarding its complexity, several features associated with the correlations of misfolding proteins and Neurodegeneration are discussed in the present study and a computational analysis for the proteins Amyloid Beta, Tau, α-Synuclein, Parkin, Pink1, MFN1, MFN1, OPA1, and DNM1L is also presented.
OriginalsprogEngelsk
TidsskriftCurrent Protein and Peptide Science
Vol/bind19
Udgave nummer9
Sider (fra-til)850-857
ISSN1389-2037
DOI
StatusUdgivet - 2018
Udgivet eksterntJa

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