Astrocyte pathology is a feature of neuromyelitis optica spectrum disorder (NMOSD) pathology. Recently mitochondrial dysfunction and metabolic changes were suggested to play a role in NMOSD. To elucidate the role of mitochondrial dysfunction, astrocyte pathology was induced in C57BL/6 J female mice by intracerebral injection of aquaporin-4-immunoglobulin G from an NMOSD patient, together with complement. Etomoxir has been shown to cause mitochondrial dysfunction. Etomoxir was delivered to the central nervous system and resulted in decreased astrocyte pathology. The ameliorating effect was associated with increases in different acylcarnitines and amino acids. This suggests that mitochondria may be a therapeutic target in NMOSD.
Bibliografisk noteFunding Information:
This research was supported by the Danish Multiple Sclerosis Society ; The Lundbeck Foundation (# R198-2015-171 ); Ph.D. stipends from The University of Southern Denmark, Health Sciences Faculty; Warwara Larsens Fond; Bjarne Jensens Fond; Augustinus Foundation; Lægefonden; Dagmar Marshalls Fond and Familien Hede Nielsens Fond.
© 2021 The Authors