MicroRNA biomarkers in glioblastoma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Recent research suggests that deregulation of microRNAs (miRNAs) is involved in initiation and progression of many cancers, including gliomas and that miRNAs hold great potential as future diagnostic and therapeutic tools in cancer. MiRNAs are a class of short non-coding RNA sequences (18-24 nucleotides), which base-pair to target messenger RNA (mRNA) and thereby cause translational repression or mRNA degradation based on the level of complementarity between strands. Profiling miRNAs in clinical glioblastoma samples has shown aberrant expression of numerous miRNAs when compared to normal brain tissues. Understanding these alterations is key to developing new biomarkers and intelligent treatment strategies. This review presents an overview of current knowledge about miRNA alterations in glioblastoma while focusing on the clinical future of miRNAs as biomarkers and discussing the strengths and weaknesses of various methods used in evaluating their expression.
OriginalsprogEngelsk
TidsskriftJournal of Neuro-Oncology
Vol/bind114
Udgave nummer1
Sider (fra-til)13-23
Antal sider11
ISSN0167-594X
DOI
StatusUdgivet - aug. 2013

Fingeraftryk Dyk ned i forskningsemnerne om 'MicroRNA biomarkers in glioblastoma'. Sammen danner de et unikt fingeraftryk.

Citationsformater