Microglia - insights into immune system structure, function, and reactivity in the central nervous system

Martin Wirenfeldt, Alicia A Babcock, Harry V Vinters

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Microglia are essential cellular components of a well-functioning central nervous system (CNS). The development and establishment of the microglial population differs from the other major cell populations in the CNS i.e. neurons and macroglia (astrocytes and oligodendrocytes). This different ontogeny gives microglia unique properties. In recent years detailed studies of the microglial population have been greatly facilitated by the use of bone marrow (BM) chimeric animals. Experimental BM transplants have provided the opportunity to trace and investigate how BM cells migrate into the CNS and settle to become microglia. Furthermore various functional properties of microglia in the normal and pathological CNS are now being revealed because of combinations of BM transplantations and experimental disease models. Here, we describe some of the latest findings in microglial biology and discuss the potential for using microglia in therapeutic interventions.
OriginalsprogEngelsk
TidsskriftHistology and Histopathology
Vol/bind26
Udgave nummer4
Sider (fra-til)519-30
Antal sider12
ISSN0213-3911
StatusUdgivet - 2011

Fingeraftryk

Microglia
Immune System
Central Nervous System
Population
Oligodendroglia
Bone Marrow Transplantation
Theoretical Models
Neurons

Citer dette

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title = "Microglia - insights into immune system structure, function, and reactivity in the central nervous system",
abstract = "Microglia are essential cellular components of a well-functioning central nervous system (CNS). The development and establishment of the microglial population differs from the other major cell populations in the CNS i.e. neurons and macroglia (astrocytes and oligodendrocytes). This different ontogeny gives microglia unique properties. In recent years detailed studies of the microglial population have been greatly facilitated by the use of bone marrow (BM) chimeric animals. Experimental BM transplants have provided the opportunity to trace and investigate how BM cells migrate into the CNS and settle to become microglia. Furthermore various functional properties of microglia in the normal and pathological CNS are now being revealed because of combinations of BM transplantations and experimental disease models. Here, we describe some of the latest findings in microglial biology and discuss the potential for using microglia in therapeutic interventions.",
keywords = "Animals, Apoptosis, Bone Marrow Transplantation, Cell Differentiation, Cell Lineage, Cell Movement, Central Nervous System, Disease Models, Animal, Humans, Immune System, Mice, Microglia, Neurons, Phagocytosis, Stem Cells, Transplantation Chimera",
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Microglia - insights into immune system structure, function, and reactivity in the central nervous system. / Wirenfeldt, Martin; Babcock, Alicia A; Vinters, Harry V.

I: Histology and Histopathology, Bind 26, Nr. 4, 2011, s. 519-30.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Microglia - insights into immune system structure, function, and reactivity in the central nervous system

AU - Wirenfeldt, Martin

AU - Babcock, Alicia A

AU - Vinters, Harry V

PY - 2011

Y1 - 2011

N2 - Microglia are essential cellular components of a well-functioning central nervous system (CNS). The development and establishment of the microglial population differs from the other major cell populations in the CNS i.e. neurons and macroglia (astrocytes and oligodendrocytes). This different ontogeny gives microglia unique properties. In recent years detailed studies of the microglial population have been greatly facilitated by the use of bone marrow (BM) chimeric animals. Experimental BM transplants have provided the opportunity to trace and investigate how BM cells migrate into the CNS and settle to become microglia. Furthermore various functional properties of microglia in the normal and pathological CNS are now being revealed because of combinations of BM transplantations and experimental disease models. Here, we describe some of the latest findings in microglial biology and discuss the potential for using microglia in therapeutic interventions.

AB - Microglia are essential cellular components of a well-functioning central nervous system (CNS). The development and establishment of the microglial population differs from the other major cell populations in the CNS i.e. neurons and macroglia (astrocytes and oligodendrocytes). This different ontogeny gives microglia unique properties. In recent years detailed studies of the microglial population have been greatly facilitated by the use of bone marrow (BM) chimeric animals. Experimental BM transplants have provided the opportunity to trace and investigate how BM cells migrate into the CNS and settle to become microglia. Furthermore various functional properties of microglia in the normal and pathological CNS are now being revealed because of combinations of BM transplantations and experimental disease models. Here, we describe some of the latest findings in microglial biology and discuss the potential for using microglia in therapeutic interventions.

KW - Animals

KW - Apoptosis

KW - Bone Marrow Transplantation

KW - Cell Differentiation

KW - Cell Lineage

KW - Cell Movement

KW - Central Nervous System

KW - Disease Models, Animal

KW - Humans

KW - Immune System

KW - Mice

KW - Microglia

KW - Neurons

KW - Phagocytosis

KW - Stem Cells

KW - Transplantation Chimera

M3 - Journal article

VL - 26

SP - 519

EP - 530

JO - Histology and Histopathology

JF - Histology and Histopathology

SN - 0213-3911

IS - 4

ER -