TY - JOUR
T1 - Microglia-Derived Insulin-like Growth Factor 1 Is Critical for Neurodevelopment
AU - Rusin, Dominika
AU - Becirovic, Lejla Vahl
AU - Lyszczarz, Gabriela Teresa
AU - Krueger, Martin
AU - Benmamar-Badel, Anouk
AU - Mathiesen, Cecilie Vad
AU - Schiöth, Eydís S.
AU - Lambertsen, Kate Lykke
AU - Wlodarczyk, Agnieszka
PY - 2024/1/18
Y1 - 2024/1/18
N2 - Insulin-like growth factor 1 (IGF-1) is a peptide hormone essential for the proper development and growth of the organism, as a complete knockout of Igf1 in mice is lethal, causing microcephaly, growth retardation and the defective development of organs. In the central nervous system, neurons and glia have been reported to express Igf1, but their relative importance for postnatal development has not yet been fully defined. In order to address this, here, we obtained mice with a microglia-specific inducible conditional knockout of Igf1. We show that the deficiency in microglial Igf1, starting in the first postnatal week, leads to body and brain growth retardation, severely impaired myelination, changes in microglia numbers, and behavioral abnormalities. These results emphasize the importance of microglial-derived Igf1 for brain development and function and open new perspectives for the investigation of the role of microglial-Igf1 in neurological diseases.
AB - Insulin-like growth factor 1 (IGF-1) is a peptide hormone essential for the proper development and growth of the organism, as a complete knockout of Igf1 in mice is lethal, causing microcephaly, growth retardation and the defective development of organs. In the central nervous system, neurons and glia have been reported to express Igf1, but their relative importance for postnatal development has not yet been fully defined. In order to address this, here, we obtained mice with a microglia-specific inducible conditional knockout of Igf1. We show that the deficiency in microglial Igf1, starting in the first postnatal week, leads to body and brain growth retardation, severely impaired myelination, changes in microglia numbers, and behavioral abnormalities. These results emphasize the importance of microglial-derived Igf1 for brain development and function and open new perspectives for the investigation of the role of microglial-Igf1 in neurological diseases.
KW - Igf1
KW - microglia
KW - neonatal microglia
KW - neophobia
KW - neurodevelopment
KW - primary myelination
KW - Neuroglia
KW - Insulin-Like Growth Factor I
KW - Insulin-Like Peptides
KW - Microglia
KW - Animals
KW - Mice
KW - Growth Disorders
U2 - 10.3390/cells13020184
DO - 10.3390/cells13020184
M3 - Journal article
C2 - 38247874
SN - 2073-4409
VL - 13
JO - Cells
JF - Cells
IS - 2
M1 - 184
ER -