Micro‑cantilevers for optical sensing of biogenic amines

Ying Wang, Carlos André Bravo Costa, Elżbieta Karolina Sobolewska, Jacek Fiutowski, Robert Brehm, Jörg Albers, Eric Nebling, Fabian Lofink, Bernhard Wagner, Wolfgang Benecke, Horst-Günter Rubahn, Roana Melina de Oliveira Hansen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


This paper discusses the functionalization of
micro-cantilevers in order to bind and sense specific biogenic
amines related to meat degradation (cadaverine). The
micro-cantilevers were functionalized with the composite
1,4,8,11-tetraazacyclotetradecane (cyclam), which is binding
to cadaverine molecules in the gas phase. Different
functionalization conditions were investigated by immersing
gold coated AFM cantilevers in cyclam solutions at different
concentrations, for different functionalization times,
and for different post-annealing treatments. The optimum
morphology for high capture efficiency is found for short
functionalization times without post-annealing treatment.
Beside qualitative SEM inspection which indicates a significant
morphology change for different functionalization
parameters, the impact of functionalization morphology
on analyte capture efficiency has been studied via
micro-cantilever based mass detection. We demonstrate
that besides conventional AFM systems a MEMS cantilever
in combination with an optical read out is a powerful
analytic system which is highly attractive for widespread
use in diagnostic applications, with optimized functionalization
conditions. The measured sensitivity at 7.7 kHz is
1.84 × 109 Hz/g.
TidsskriftMicrosystem Technologies
Udgave nummer1
Sider (fra-til)363–369
StatusUdgivet - 1. jan. 2018


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