Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

Abbas H K Al Temimi, Paul B White, Marcus J M Mulders, Nicole G A van der Linden, Richard H Blaauw, Anita Wegert, Floris P J T Rutjes*, Jasmin Mecinović*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

43 Downloads (Pure)

Abstrakt

We report synthesis and enzymatic assays on human histone lysine methyltransferase catalysed methylation of histones that possess lysine and its geometrically constrained analogues containing rigid (E)-alkene (KE), (Z)-alkene (KZ) and alkyne (Kyne) moieties. Methyltransferases G9a and GLP do have a capacity to catalyse methylation in the order K ≫ KE > KZ ∼ Kyne, whereas monomethyltransferase SETD8 catalyses only methylation of K and KE.

OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind56
Udgave nummer20
Sider (fra-til)3039-3042
ISSN1359-7345
DOI
StatusUdgivet - 2020

Fingeraftryk Dyk ned i forskningsemnerne om 'Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases'. Sammen danner de et unikt fingeraftryk.

Citationsformater