Metformin og kirurgi i generel anæstesi

Elisabeth Lauritzen, David Hebbelstrup Jensen, Christian Bonde, Henning Beck-Nielsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Danish national guidelines recommend discontinuation of metformin 48 h prior to general anaesthesia due to the presumed increased risk of lactic acidosis. By reviewing recent studies concerning the risk of metformin-associated lactic acidosis it is found, that studies indicate, that metformin does not increase the risk of lactic acidosis. However, comorbidities such as cardiovascular insufficiency, sepsis, dehydration and impaired kidney function are risk factors. New guidelines propose discontinuation of metformin on the day of surgery. Patients with Type 2 diabetes and comorbidities should have the levels of arterial pH and lactate monitored.
Bidragets oversatte titelMetformin and surgery before general anaesthesia
OriginalsprogDansk
ArtikelnummerV08180593
TidsskriftUgeskrift for Laeger
Vol/bind181
Udgave nummer17
ISSN0041-5782
StatusUdgivet - 2019

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