Metabolic regulation of lifespan from a C. Elegans perspective

Kathrine B. Dall, Nils J. Færgeman*

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Resumé

Decline of cellular functions especially cognitive is a major deficit that arises with age in humans. Harnessing the strengths of small and genetic tractable model systems has revealed key conserved regulatory biochemical and signaling pathways that control aging. Here, we review some of the key signaling and biochemical pathways that coordinate aging processes with special emphasis on Caenorhabditis elegans as a model system and discuss how nutrients and metabolites can regulate lifespan by coordinating signaling and epigenetic programs. We focus on central nutrient-sensing pathways such as mTOR and insulin/insulin-like growth factor signaling and key transcription factors including the conserved basic helix-loop-helix transcription factor HLH-30/TFEB.

OriginalsprogEngelsk
Artikelnummer25
TidsskriftGenes and Nutrition
Vol/bind14
Sider (fra-til)14-25
Antal sider12
ISSN1555-8932
DOI
StatusUdgivet - 2019

Fingeraftryk

Food
Genetic Models
Caenorhabditis elegans
Epigenomics
Cognition
Insulin

Citer dette

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abstract = "Decline of cellular functions especially cognitive is a major deficit that arises with age in humans. Harnessing the strengths of small and genetic tractable model systems has revealed key conserved regulatory biochemical and signaling pathways that control aging. Here, we review some of the key signaling and biochemical pathways that coordinate aging processes with special emphasis on Caenorhabditis elegans as a model system and discuss how nutrients and metabolites can regulate lifespan by coordinating signaling and epigenetic programs. We focus on central nutrient-sensing pathways such as mTOR and insulin/insulin-like growth factor signaling and key transcription factors including the conserved basic helix-loop-helix transcription factor HLH-30/TFEB.",
keywords = "Aging, Autophagy, Caenorhabditis elegans, Dietary restriction, Epigenetics, HLH-30/TFEB, Longevity, Metabolism",
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Metabolic regulation of lifespan from a C. Elegans perspective. / Dall, Kathrine B.; Færgeman, Nils J.

I: Genes and Nutrition, Bind 14, 25, 2019, s. 14-25.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Metabolic regulation of lifespan from a C. Elegans perspective

AU - Dall, Kathrine B.

AU - Færgeman, Nils J.

PY - 2019

Y1 - 2019

N2 - Decline of cellular functions especially cognitive is a major deficit that arises with age in humans. Harnessing the strengths of small and genetic tractable model systems has revealed key conserved regulatory biochemical and signaling pathways that control aging. Here, we review some of the key signaling and biochemical pathways that coordinate aging processes with special emphasis on Caenorhabditis elegans as a model system and discuss how nutrients and metabolites can regulate lifespan by coordinating signaling and epigenetic programs. We focus on central nutrient-sensing pathways such as mTOR and insulin/insulin-like growth factor signaling and key transcription factors including the conserved basic helix-loop-helix transcription factor HLH-30/TFEB.

AB - Decline of cellular functions especially cognitive is a major deficit that arises with age in humans. Harnessing the strengths of small and genetic tractable model systems has revealed key conserved regulatory biochemical and signaling pathways that control aging. Here, we review some of the key signaling and biochemical pathways that coordinate aging processes with special emphasis on Caenorhabditis elegans as a model system and discuss how nutrients and metabolites can regulate lifespan by coordinating signaling and epigenetic programs. We focus on central nutrient-sensing pathways such as mTOR and insulin/insulin-like growth factor signaling and key transcription factors including the conserved basic helix-loop-helix transcription factor HLH-30/TFEB.

KW - Aging

KW - Autophagy

KW - Caenorhabditis elegans

KW - Dietary restriction

KW - Epigenetics

KW - HLH-30/TFEB

KW - Longevity

KW - Metabolism

U2 - 10.1186/s12263-019-0650-x

DO - 10.1186/s12263-019-0650-x

M3 - Review

C2 - 31428207

AN - SCOPUS:85071044539

VL - 14

SP - 14

EP - 25

JO - Genes & Nutrition

JF - Genes & Nutrition

SN - 1555-8932

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ER -