@article{3022ac807bb511df846a000ea68e967b,
title = "Metabolic effect of islet B-cell function in insulin-treated diabetes",
abstract = "We studied the relationship between endogenous insulin secretion and fasting levels of plasma free fatty acids (FFA), plasma acetoacetate plus plasma 3-hydroxybutyrate (total ketone bodies), blood glucose, and HbA1 in 132 diabetic outpatients treated with conventional insulin regimens. Patients were divided into four groups according to plasma C-peptide concentration after intravenous stimulation with glucagon: one group with C-peptide stimulation less than 0.06 nmol/l, one group with C-peptide stimulation 0.06- less than 0.32 nmol/l, one group with C-peptide stimulation 0.32- less than 0.60 nmol/l, and one group with C-peptide stimulation greater than 0.60 nmol/l. According to clinical criteria the prevalence of insulin-dependent diabetes mellitus was approximately 90\% in patients with C-peptide stimulation less than 0.32 nmol/l, approximately 25\% in patients with C-peptide stimulation from 0.32- less than 0.60 nmol/l, and approximately 10\% in patients with C-peptide stimulation greater than 0.60 nmol/l. All metabolic variables were significantly higher in patients without detectable C-peptide in plasma when compared to values found in patients with C-peptide stimulation from 0.06- less than 0.32 nmol/l. These two patient groups also had similar peripheral plasma free insulin levels and were comparable according to age, sex, and body mass index.(ABSTRACT TRUNCATED AT 250 WORDS)",
keywords = "Adult, Aged, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Fasting, Fatty Acids, Nonesterified, Female, Hemoglobin A, Glycosylated, Humans, Insulin, Islets of Langerhans, Ketone Bodies, Male, Middle Aged",
author = "Gjessing, \{H J\} and Matzen, \{L E\} and S Iversen and Faber, \{O K\} and A Fr{\o}land",
year = "1989",
doi = "10.3109/00365518909089106",
language = "English",
volume = "49",
pages = "337--43",
journal = "Scandinavian Journal of Clinical \& Laboratory Investigation",
issn = "0036-5513",
publisher = "Informa Healthcare",
number = "4",
}