Mesenchymal Stem Cells: Application for Immunomodulation and Tissue Repair

Nicole J. Horwood, Francesco Dazzi, Walid Zaher, Moustapha Kassem

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Resumé

Mesenchymal stem cells (MSC) are stem cell populations present among the bone marrow stroma and a number of other tissues that are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts, adipocytes and chondrocytes. MSC provide supportive stroma for growth and differentiation of hematopoietic stem cells (HSC) and hematopoiesis. These cells have been described as important immunoregulators due to their ability to suppress T cells proliferation. MSC can also directly contribute to tissue repair by migrating to sites of injury and providing a source of cells for differentiation and/or providing bystander support for resident stromal cells. This chapter discusses the cellular and molecular properties of MSC, the mechanisms by which they can modulate immune responses and the clinical applications of MSC in disorders such as graft-versus-host disease and aplastic anaemia. The role of MSC in the treatment of autoimmune disorders as well as their potential in the arena of tissue repair and a view of what the future clinical applications of MSC might be is outlined in this chapter.
OriginalsprogEngelsk
TitelTissue and Cell Clinical Use : An Essential Guide
RedaktørerRuth M Warwick, Scott A. Brubaker
ForlagWiley-Blackwell
Publikationsdato2012
Sider332-357
Kapitel16
ISBN (Trykt)9781405198257
ISBN (Elektronisk)9781118498453
DOI
StatusUdgivet - 2012

Fingeraftryk

Mesenchymal Stromal Cells
Graft vs Host Disease
Mesoderm
Stromal Cells
Chondrocytes
Osteoblasts
Adipocytes
Cell Differentiation
Cell Proliferation
Wounds and Injuries
Growth
Population

Citer dette

Horwood, N. J., Dazzi, F., Zaher, W., & Kassem, M. (2012). Mesenchymal Stem Cells: Application for Immunomodulation and Tissue Repair. I R. M. Warwick, & S. A. Brubaker (red.), Tissue and Cell Clinical Use: An Essential Guide (s. 332-357). Wiley-Blackwell. https://doi.org/10.1002/9781118498453.ch16
Horwood, Nicole J. ; Dazzi, Francesco ; Zaher, Walid ; Kassem, Moustapha. / Mesenchymal Stem Cells : Application for Immunomodulation and Tissue Repair. Tissue and Cell Clinical Use: An Essential Guide . red. / Ruth M Warwick ; Scott A. Brubaker. Wiley-Blackwell, 2012. s. 332-357
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Horwood, NJ, Dazzi, F, Zaher, W & Kassem, M 2012, Mesenchymal Stem Cells: Application for Immunomodulation and Tissue Repair. i RM Warwick & SA Brubaker (red), Tissue and Cell Clinical Use: An Essential Guide . Wiley-Blackwell, s. 332-357. https://doi.org/10.1002/9781118498453.ch16

Mesenchymal Stem Cells : Application for Immunomodulation and Tissue Repair. / Horwood, Nicole J. ; Dazzi, Francesco; Zaher, Walid; Kassem, Moustapha.

Tissue and Cell Clinical Use: An Essential Guide . red. / Ruth M Warwick; Scott A. Brubaker. Wiley-Blackwell, 2012. s. 332-357.

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

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AB - Mesenchymal stem cells (MSC) are stem cell populations present among the bone marrow stroma and a number of other tissues that are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts, adipocytes and chondrocytes. MSC provide supportive stroma for growth and differentiation of hematopoietic stem cells (HSC) and hematopoiesis. These cells have been described as important immunoregulators due to their ability to suppress T cells proliferation. MSC can also directly contribute to tissue repair by migrating to sites of injury and providing a source of cells for differentiation and/or providing bystander support for resident stromal cells. This chapter discusses the cellular and molecular properties of MSC, the mechanisms by which they can modulate immune responses and the clinical applications of MSC in disorders such as graft-versus-host disease and aplastic anaemia. The role of MSC in the treatment of autoimmune disorders as well as their potential in the arena of tissue repair and a view of what the future clinical applications of MSC might be is outlined in this chapter.

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Horwood NJ, Dazzi F, Zaher W, Kassem M. Mesenchymal Stem Cells: Application for Immunomodulation and Tissue Repair. I Warwick RM, Brubaker SA, red., Tissue and Cell Clinical Use: An Essential Guide . Wiley-Blackwell. 2012. s. 332-357 https://doi.org/10.1002/9781118498453.ch16