Mental health among patients with non-Hodgkin lymphoma: A Danish nationwide study of psychotropic drug use in 8750 patients and 43 750 matched comparators

Andreas Kiesbye Øvlisen*, Lasse Hjort Jakobsen, Kristian Hay Kragholm, René Ernst Nielsen, Peter de Nully Brown, Rasmus Bo Dahl-Sørensen, Henrik Frederiksen, Nikolaj Mannering, Pär Lars Josefsson, Ahmed Ludvigsen Al-Mashhadi, Judit Mészáros Jørgensen, Andriette Dessau-Arp, Michael Roost Clausen, Robert Schou Pedersen, Christian Torp-Pedersen, Marianne Tang Severinsen, Tarec Christoffer El-Galaly


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Psychological distress following cancer diagnosis may lead to mental health complications including depression and anxiety. Non-Hodgkin lymphomas (NHLs) include indolent and aggressive subtypes for which treatment and prognosis differ widely. Incident use of psychotropic drugs (PDs—antidepressants, antipsychotics, and anxiolytics) and its correlation to lymphoma types can give insights into the psychological distress these patients endure. In this prospective matched cohort study, we used nationwide population-based registries to investigate the cumulative risk of PD use in NHL patients compared to a sex- and age-matched cohort from the Danish background population. In addition, contact patterns to psychiatric departments and incident intentional self-harm or completed suicide were explored. In total, 8750 NHL patients and 43 750 matched comparators were included (median age 68; male:female ratio 1.6). Median follow-up was 7.1 years. Two-year cumulative risk of PD use was higher in NHL patients (16.4%) as compared to the matched comparators (5.1%, p <.01); patients with aggressive NHL subtypes had the highest incidence. Prescription rates were higher in the first years after diagnosis but approached the rate of the matched population 5 years into survivorship in aggressive NHLs, whereas patients with indolent subtypes continued to be at higher risk. NHL patients had a slightly higher two-year risk of suicide/intentional self-harm (0.3%) as compared to the matched comparators (0.2%, p =.01). These results demonstrate that mental health complications among NHL patients are frequent. Routine assessment for symptoms of depression and anxiety should be consider as part of standard follow-up of NHL patients.

TidsskriftAmerican Journal of Hematology
Udgave nummer6
Sider (fra-til)749-761
StatusUdgivet - 1. jun. 2022

Bibliografisk note

Funding Information:
AKØ: Covered travel expenses from Pfizer and AbbVie. TCEG: Previous employment by Roche Ltd, Basel, speakers fee Abbvie. KK: Reported speaker's honoraria from Novartis, unrelated to this work. REN: Reported receiving research grants from H. Lundbeck and Otsuka Pharmaceuticals for clinical trials, receiving speaking fees from Bristol‐Myers Squibb, Astra Zeneca, Janssen & Cilag, Lundbeck, Servier, Otsuka Pharmaceuticals, Teva A/S, and Eli Lilly and has acted as advisor to Astra Zeneca, Eli Lilly, Lundbeck, Otsuka Pharmaceuticals, Takeda, and Medivir, and being an investigator for Janssen‐Cilag, Lundbeck, Boehringer, Compass, and Sage. HF: Received research grants outside this work from Alexion, Gilead, Abbvie, Janssen Pharmaceuticals, and Novartis. PB: Advisor for BMS, Takeda, Roche, Novartis and Incyte. JMJ: Roche, Gilead, Novartis, BMS: Advisory board, not related to this work. RBDS: Travel expenses from Takeda. MRC: Received speaking fee from Janssen, travel grant from Roche and Gilead. Participated in advisory boards for Abbvie and Janssen. All outside this work.

Publisher Copyright:
© 2022 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.


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