Measurements and Implications of How Electrical Potentials Can Bend Membranes

Dennis Bruhn, Weria Pezeshkian, Himanshu Khandelia

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Abstrakt

Lipid bilayer membranes are liquid crystals. The oppositely oriented head group dipoles in the lipid head groups makes the bilayer leaflets respond differently to applied electrical potential. While the density of dipoles decreases in one leaflet, it increases in the other leaflet upon application of a transmembrane electrical potential, thus resulting in bending of the bilayer. We investigated this flexoelectric phenomenon using coarse grained molecular dynamics simulations and show that increasing potentials bend the membrane to a larger extent. We demonstrate the implications of the phenomenon in the tubulation of giant unilamellar vesicles upon application of a calcium flux.
OriginalsprogEngelsk
TidsskriftBiophysical Journal
Vol/bind114
Udgave nummer3, Suppl. 1
Sider (fra-til)94A
Antal sider1
ISSN0006-3495
DOI
StatusUdgivet - 2. feb. 2018

Bibliografisk note

62nd Annual Meeting of the Biophysical-Society, San Francisco, CA, FEB 17-21, 2018

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