Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring

Ingeborg Forthun, Allen J Wilcox, Katrine Strandberg-Larsen, Dag Moster, Ellen A Nohr, Rolv Terje Lie, Pål Surén, Mette C Tollånes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVES: To investigate the association between maternal pre-pregnancy BMI and risk of cerebral palsy (CP) in offspring.

METHODS: The study population consisted of 188 788 children in the Mothers and Babies in Norway and Denmark CP study, using data from 2 population-based, prospective birth cohorts: the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Prepregnancy BMI was classified as underweight (BMI <18.5), lower normal weight (BMI 18.5-22.9), upper normal weight (BMI 23.0-24.9), overweight (BMI 25.0-29.9), and obese (BMI ≥30). CP diagnoses were obtained from the national CP registries. Associations between maternal prepregnancy BMI and CP in offspring were investigated by using log-binomial regression models.

RESULTS: The 2 cohorts had 390 eligible cases of CP (2.1 per 1000 live-born children). Compared with mothers in the lower normal weight group, mothers in the upper normal group had a 40% excess risk of having a child with CP (relative risk [RR], 1.35; 95% confidence interval [CI], 1.03-1.78). Excess risk was 60% (RR, 1.56; 95% CI, 1.21-2.01) for overweight mothers and 60% (RR, 1.55; 95% CI 1.11-2.18) for obese mothers. The risk of CP increased ∼4% for each unit increase in BMI (RR, 1.04; 95% CI, 1.02-1.06). Estimates changed little with adjustment for mother's occupational status, age, and smoking habits.

CONCLUSIONS: Higher prepregnancy maternal BMI was associated with increased risk of CP in offspring.

OriginalsprogEngelsk
Artikelnummere 20160874
TidsskriftPediatrics
Vol/bind138
Udgave nummer4
Sider (fra-til)1-9
ISSN0031-4005
DOI
StatusUdgivet - 2016

Fingeraftryk

Cerebral Palsy
Mothers
Confidence Intervals
Weights and Measures
Statistical Models
Denmark
Norway
Population
Habits
Registries
Cohort Studies
Smoking

Citer dette

Forthun, I., Wilcox, A. J., Strandberg-Larsen, K., Moster, D., Nohr, E. A., Lie, R. T., ... Tollånes, M. C. (2016). Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring. Pediatrics, 138(4), 1-9. [e 20160874 ]. https://doi.org/10.1542/peds.2016-0874
Forthun, Ingeborg ; Wilcox, Allen J ; Strandberg-Larsen, Katrine ; Moster, Dag ; Nohr, Ellen A ; Lie, Rolv Terje ; Surén, Pål ; Tollånes, Mette C. / Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring. I: Pediatrics. 2016 ; Bind 138, Nr. 4. s. 1-9.
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abstract = "OBJECTIVES: To investigate the association between maternal pre-pregnancy BMI and risk of cerebral palsy (CP) in offspring.METHODS: The study population consisted of 188 788 children in the Mothers and Babies in Norway and Denmark CP study, using data from 2 population-based, prospective birth cohorts: the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Prepregnancy BMI was classified as underweight (BMI <18.5), lower normal weight (BMI 18.5-22.9), upper normal weight (BMI 23.0-24.9), overweight (BMI 25.0-29.9), and obese (BMI ≥30). CP diagnoses were obtained from the national CP registries. Associations between maternal prepregnancy BMI and CP in offspring were investigated by using log-binomial regression models.RESULTS: The 2 cohorts had 390 eligible cases of CP (2.1 per 1000 live-born children). Compared with mothers in the lower normal weight group, mothers in the upper normal group had a 40{\%} excess risk of having a child with CP (relative risk [RR], 1.35; 95{\%} confidence interval [CI], 1.03-1.78). Excess risk was 60{\%} (RR, 1.56; 95{\%} CI, 1.21-2.01) for overweight mothers and 60{\%} (RR, 1.55; 95{\%} CI 1.11-2.18) for obese mothers. The risk of CP increased ∼4{\%} for each unit increase in BMI (RR, 1.04; 95{\%} CI, 1.02-1.06). Estimates changed little with adjustment for mother's occupational status, age, and smoking habits.CONCLUSIONS: Higher prepregnancy maternal BMI was associated with increased risk of CP in offspring.",
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Forthun, I, Wilcox, AJ, Strandberg-Larsen, K, Moster, D, Nohr, EA, Lie, RT, Surén, P & Tollånes, MC 2016, 'Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring', Pediatrics, bind 138, nr. 4, e 20160874 , s. 1-9. https://doi.org/10.1542/peds.2016-0874

Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring. / Forthun, Ingeborg; Wilcox, Allen J; Strandberg-Larsen, Katrine; Moster, Dag; Nohr, Ellen A; Lie, Rolv Terje; Surén, Pål; Tollånes, Mette C.

I: Pediatrics, Bind 138, Nr. 4, e 20160874 , 2016, s. 1-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring

AU - Forthun, Ingeborg

AU - Wilcox, Allen J

AU - Strandberg-Larsen, Katrine

AU - Moster, Dag

AU - Nohr, Ellen A

AU - Lie, Rolv Terje

AU - Surén, Pål

AU - Tollånes, Mette C

N1 - Copyright © 2016 by the American Academy of Pediatrics.

PY - 2016

Y1 - 2016

N2 - OBJECTIVES: To investigate the association between maternal pre-pregnancy BMI and risk of cerebral palsy (CP) in offspring.METHODS: The study population consisted of 188 788 children in the Mothers and Babies in Norway and Denmark CP study, using data from 2 population-based, prospective birth cohorts: the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Prepregnancy BMI was classified as underweight (BMI <18.5), lower normal weight (BMI 18.5-22.9), upper normal weight (BMI 23.0-24.9), overweight (BMI 25.0-29.9), and obese (BMI ≥30). CP diagnoses were obtained from the national CP registries. Associations between maternal prepregnancy BMI and CP in offspring were investigated by using log-binomial regression models.RESULTS: The 2 cohorts had 390 eligible cases of CP (2.1 per 1000 live-born children). Compared with mothers in the lower normal weight group, mothers in the upper normal group had a 40% excess risk of having a child with CP (relative risk [RR], 1.35; 95% confidence interval [CI], 1.03-1.78). Excess risk was 60% (RR, 1.56; 95% CI, 1.21-2.01) for overweight mothers and 60% (RR, 1.55; 95% CI 1.11-2.18) for obese mothers. The risk of CP increased ∼4% for each unit increase in BMI (RR, 1.04; 95% CI, 1.02-1.06). Estimates changed little with adjustment for mother's occupational status, age, and smoking habits.CONCLUSIONS: Higher prepregnancy maternal BMI was associated with increased risk of CP in offspring.

AB - OBJECTIVES: To investigate the association between maternal pre-pregnancy BMI and risk of cerebral palsy (CP) in offspring.METHODS: The study population consisted of 188 788 children in the Mothers and Babies in Norway and Denmark CP study, using data from 2 population-based, prospective birth cohorts: the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Prepregnancy BMI was classified as underweight (BMI <18.5), lower normal weight (BMI 18.5-22.9), upper normal weight (BMI 23.0-24.9), overweight (BMI 25.0-29.9), and obese (BMI ≥30). CP diagnoses were obtained from the national CP registries. Associations between maternal prepregnancy BMI and CP in offspring were investigated by using log-binomial regression models.RESULTS: The 2 cohorts had 390 eligible cases of CP (2.1 per 1000 live-born children). Compared with mothers in the lower normal weight group, mothers in the upper normal group had a 40% excess risk of having a child with CP (relative risk [RR], 1.35; 95% confidence interval [CI], 1.03-1.78). Excess risk was 60% (RR, 1.56; 95% CI, 1.21-2.01) for overweight mothers and 60% (RR, 1.55; 95% CI 1.11-2.18) for obese mothers. The risk of CP increased ∼4% for each unit increase in BMI (RR, 1.04; 95% CI, 1.02-1.06). Estimates changed little with adjustment for mother's occupational status, age, and smoking habits.CONCLUSIONS: Higher prepregnancy maternal BMI was associated with increased risk of CP in offspring.

U2 - 10.1542/peds.2016-0874

DO - 10.1542/peds.2016-0874

M3 - Journal article

C2 - 27609826

VL - 138

SP - 1

EP - 9

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 4

M1 - e 20160874

ER -

Forthun I, Wilcox AJ, Strandberg-Larsen K, Moster D, Nohr EA, Lie RT et al. Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring. Pediatrics. 2016;138(4):1-9. e 20160874 . https://doi.org/10.1542/peds.2016-0874