Maternal measles antibodies and their influence on all-cause mortality following measles vaccination: an alternative to measure very low maternal antibody levels

Gaby Smits, Christine Stabell Benn, Hilton Whittle, Rob van Binnendijk, Peter Aaby, Fiona van der Klis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

It was previously shown by hemagglutination inhibition that measles vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/mL) that correlates with lower all-cause mortality (P = .02).

OriginalsprogEngelsk
TidsskriftClinical Infectious Diseases
Vol/bind68
Udgave nummer10
Sider (fra-til)1758-1760
ISSN1058-4838
DOI
StatusUdgivet - 2. maj 2019

Fingeraftryk

Measles
Mothers
Immunoassay

Citer dette

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abstract = "It was previously shown by hemagglutination inhibition that measles vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/mL) that correlates with lower all-cause mortality (P = .02).",
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Maternal measles antibodies and their influence on all-cause mortality following measles vaccination : an alternative to measure very low maternal antibody levels. / Smits, Gaby; Stabell Benn, Christine; Whittle, Hilton; van Binnendijk, Rob; Aaby, Peter; van der Klis, Fiona.

I: Clinical Infectious Diseases, Bind 68, Nr. 10, 02.05.2019, s. 1758-1760.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

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T2 - an alternative to measure very low maternal antibody levels

AU - Smits, Gaby

AU - Stabell Benn, Christine

AU - Whittle, Hilton

AU - van Binnendijk, Rob

AU - Aaby, Peter

AU - van der Klis, Fiona

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AB - It was previously shown by hemagglutination inhibition that measles vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/mL) that correlates with lower all-cause mortality (P = .02).

KW - All-causemortality

KW - HAI

KW - Maternalmeaslesantibodies

KW - Multiplex immunoassay

U2 - 10.1093/cid/ciy900

DO - 10.1093/cid/ciy900

M3 - Journal article

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

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