Maternal measles antibodies and their influence on all-cause mortality following measles vaccination: an alternative to measure very low maternal antibody levels

Gaby Smits, Christine Stabell Benn, Hilton Whittle, Rob van Binnendijk, Peter Aaby, Fiona van der Klis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

It was previously shown by hemagglutination inhibition that measles vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/mL) that correlates with lower all-cause mortality (P = .02).

OriginalsprogEngelsk
TidsskriftClinical Infectious Diseases
Vol/bind68
Udgave nummer10
Sider (fra-til)1758-1760
ISSN1058-4838
DOI
StatusUdgivet - 2. maj 2019

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