Maternal bereavement and cryptorchidism in offspring

Katja Glejsted Ingstrup, Jørn Olsen, Chunsen Wu, Ellen Aagaard Nohr, Bodil Hammer Bech, Jiong Li, Ezra Susser, Morten Søndergaard Jensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Cryptorchidism (undescended testis) is a common anomaly with largely unexplained etiology. Animal studies have suggested maternal emotional stress as a potential risk factor, but this has not been studied in humans. We aimed to investigate whether maternal bereavement due to the death of a close relative in the antenatal period increases the occurrence of cryptorchidism in the offspring.

METHODS: In a population-based cohort, we studied death of a close relative as the exposure and cryptorchidism entries in nationwide medical registries as the outcome. Danish national registries included 898,961 (23,609 exposed) boys born from 1978 to 2008 with a maximum of 30 years of follow-up.

RESULTS: A total of 20,947 boys had cryptorchidism, of whom 13,524 also underwent corrective surgery. We found no increased occurrence of cryptorchidism in the offspring (hazard ratio = 1.02 [95% confidence interval = 0.92-1.14]). Results were similar when the diagnosis was verified with surgery. We adjusted for maternal and paternal age, birth year, and family history of cryptorchidism.

CONCLUSION: We observed no association between maternal bereavement before and during pregnancy and the occurrence of cryptorchidism in the offspring.

OriginalsprogEngelsk
TidsskriftEpidemiology
Vol/bind26
Udgave nummer1
Sider (fra-til)100-5
ISSN1044-3983
DOI
StatusUdgivet - jan. 2015

Fingeraftryk

Cryptorchidism
Mothers
Registries
Paternal Age
Maternal Age
Confidence Intervals

Citer dette

Ingstrup, K. G., Olsen, J., Wu, C., Nohr, E. A., Bech, B. H., Li, J., ... Jensen, M. S. (2015). Maternal bereavement and cryptorchidism in offspring. Epidemiology, 26(1), 100-5. https://doi.org/10.1097/EDE.0000000000000194
Ingstrup, Katja Glejsted ; Olsen, Jørn ; Wu, Chunsen ; Nohr, Ellen Aagaard ; Bech, Bodil Hammer ; Li, Jiong ; Susser, Ezra ; Jensen, Morten Søndergaard. / Maternal bereavement and cryptorchidism in offspring. I: Epidemiology. 2015 ; Bind 26, Nr. 1. s. 100-5.
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abstract = "BACKGROUND: Cryptorchidism (undescended testis) is a common anomaly with largely unexplained etiology. Animal studies have suggested maternal emotional stress as a potential risk factor, but this has not been studied in humans. We aimed to investigate whether maternal bereavement due to the death of a close relative in the antenatal period increases the occurrence of cryptorchidism in the offspring.METHODS: In a population-based cohort, we studied death of a close relative as the exposure and cryptorchidism entries in nationwide medical registries as the outcome. Danish national registries included 898,961 (23,609 exposed) boys born from 1978 to 2008 with a maximum of 30 years of follow-up.RESULTS: A total of 20,947 boys had cryptorchidism, of whom 13,524 also underwent corrective surgery. We found no increased occurrence of cryptorchidism in the offspring (hazard ratio = 1.02 [95{\%} confidence interval = 0.92-1.14]). Results were similar when the diagnosis was verified with surgery. We adjusted for maternal and paternal age, birth year, and family history of cryptorchidism.CONCLUSION: We observed no association between maternal bereavement before and during pregnancy and the occurrence of cryptorchidism in the offspring.",
author = "Ingstrup, {Katja Glejsted} and J{\o}rn Olsen and Chunsen Wu and Nohr, {Ellen Aagaard} and Bech, {Bodil Hammer} and Jiong Li and Ezra Susser and Jensen, {Morten S{\o}ndergaard}",
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Ingstrup, KG, Olsen, J, Wu, C, Nohr, EA, Bech, BH, Li, J, Susser, E & Jensen, MS 2015, 'Maternal bereavement and cryptorchidism in offspring', Epidemiology, bind 26, nr. 1, s. 100-5. https://doi.org/10.1097/EDE.0000000000000194

Maternal bereavement and cryptorchidism in offspring. / Ingstrup, Katja Glejsted; Olsen, Jørn; Wu, Chunsen; Nohr, Ellen Aagaard; Bech, Bodil Hammer; Li, Jiong; Susser, Ezra; Jensen, Morten Søndergaard.

I: Epidemiology, Bind 26, Nr. 1, 01.2015, s. 100-5.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Maternal bereavement and cryptorchidism in offspring

AU - Ingstrup, Katja Glejsted

AU - Olsen, Jørn

AU - Wu, Chunsen

AU - Nohr, Ellen Aagaard

AU - Bech, Bodil Hammer

AU - Li, Jiong

AU - Susser, Ezra

AU - Jensen, Morten Søndergaard

PY - 2015/1

Y1 - 2015/1

N2 - BACKGROUND: Cryptorchidism (undescended testis) is a common anomaly with largely unexplained etiology. Animal studies have suggested maternal emotional stress as a potential risk factor, but this has not been studied in humans. We aimed to investigate whether maternal bereavement due to the death of a close relative in the antenatal period increases the occurrence of cryptorchidism in the offspring.METHODS: In a population-based cohort, we studied death of a close relative as the exposure and cryptorchidism entries in nationwide medical registries as the outcome. Danish national registries included 898,961 (23,609 exposed) boys born from 1978 to 2008 with a maximum of 30 years of follow-up.RESULTS: A total of 20,947 boys had cryptorchidism, of whom 13,524 also underwent corrective surgery. We found no increased occurrence of cryptorchidism in the offspring (hazard ratio = 1.02 [95% confidence interval = 0.92-1.14]). Results were similar when the diagnosis was verified with surgery. We adjusted for maternal and paternal age, birth year, and family history of cryptorchidism.CONCLUSION: We observed no association between maternal bereavement before and during pregnancy and the occurrence of cryptorchidism in the offspring.

AB - BACKGROUND: Cryptorchidism (undescended testis) is a common anomaly with largely unexplained etiology. Animal studies have suggested maternal emotional stress as a potential risk factor, but this has not been studied in humans. We aimed to investigate whether maternal bereavement due to the death of a close relative in the antenatal period increases the occurrence of cryptorchidism in the offspring.METHODS: In a population-based cohort, we studied death of a close relative as the exposure and cryptorchidism entries in nationwide medical registries as the outcome. Danish national registries included 898,961 (23,609 exposed) boys born from 1978 to 2008 with a maximum of 30 years of follow-up.RESULTS: A total of 20,947 boys had cryptorchidism, of whom 13,524 also underwent corrective surgery. We found no increased occurrence of cryptorchidism in the offspring (hazard ratio = 1.02 [95% confidence interval = 0.92-1.14]). Results were similar when the diagnosis was verified with surgery. We adjusted for maternal and paternal age, birth year, and family history of cryptorchidism.CONCLUSION: We observed no association between maternal bereavement before and during pregnancy and the occurrence of cryptorchidism in the offspring.

U2 - 10.1097/EDE.0000000000000194

DO - 10.1097/EDE.0000000000000194

M3 - Journal article

C2 - 25329541

VL - 26

SP - 100

EP - 105

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 1

ER -