Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring: a large population-based pooling study

Lisa A. DeRoo, Allen J Wilcox, Rolv T Lie, Paul A. Romitti, D. A. Pedersen, Ronald G Munger, Linda M. Moreno Uribe, George L Wehby

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Using individual participant data from six population-based case–control studies, we conducted pooled analyses to examine maternal alcohol consumption and the risk of clefts among >4600 infants with cleft lip only, cleft lip with cleft palate, or cleft palate only and >10,000 unaffected controls. We examined two first-trimester alcohol measures: average number of drinks/sitting and maximum number of drinks/sitting, with five studies contributing to each analysis. Study-specific odds ratios (ORs) were estimated using logistic regression and pooled to generate adjusted summary ORs. Across studies, 0.9–3.2 % of control mothers reported drinking an average of 5+ drinks/sitting, while 1.4–23.5 % reported drinking a maximum of 5+ drinks/sitting. Compared with non-drinkers, mothers who drank an average of 5+ drinks/sitting were more likely to deliver an infant with cleft lip only (pooled OR 1.48; 95 % confidence intervals 1.01, 2.18). The estimate was higher among women who drank at this level 3+ times (pooled OR 1.95; 1.23, 3.11). Ever drinking a maximum of 5+ drinks/sitting and non-binge drinking were not associated with cleft risk. Repeated heavy maternal alcohol consumption was associated with an increased risk of cleft lip only in offspring. There was little evidence of increased risk for other cleft types or alcohol measures. © 2016, The Author(s).
OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind31
Udgave nummer10
Sider (fra-til)1021-1034
ISSN0393-2990
DOI
StatusUdgivet - 2016

Bibliografisk note

Cited By :2 Export Date: 22 March 2017 CODEN: EJEPE

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DeRoo, Lisa A. ; Wilcox, Allen J ; Lie, Rolv T ; Romitti, Paul A. ; Pedersen, D. A. ; Munger, Ronald G ; Moreno Uribe, Linda M. ; Wehby, George L. / Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring : a large population-based pooling study. I: European Journal of Epidemiology. 2016 ; Bind 31, Nr. 10. s. 1021-1034.
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title = "Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring: a large population-based pooling study",
abstract = "Using individual participant data from six population-based case–control studies, we conducted pooled analyses to examine maternal alcohol consumption and the risk of clefts among >4600 infants with cleft lip only, cleft lip with cleft palate, or cleft palate only and >10,000 unaffected controls. We examined two first-trimester alcohol measures: average number of drinks/sitting and maximum number of drinks/sitting, with five studies contributing to each analysis. Study-specific odds ratios (ORs) were estimated using logistic regression and pooled to generate adjusted summary ORs. Across studies, 0.9–3.2 {\%} of control mothers reported drinking an average of 5+ drinks/sitting, while 1.4–23.5 {\%} reported drinking a maximum of 5+ drinks/sitting. Compared with non-drinkers, mothers who drank an average of 5+ drinks/sitting were more likely to deliver an infant with cleft lip only (pooled OR 1.48; 95 {\%} confidence intervals 1.01, 2.18). The estimate was higher among women who drank at this level 3+ times (pooled OR 1.95; 1.23, 3.11). Ever drinking a maximum of 5+ drinks/sitting and non-binge drinking were not associated with cleft risk. Repeated heavy maternal alcohol consumption was associated with an increased risk of cleft lip only in offspring. There was little evidence of increased risk for other cleft types or alcohol measures. {\circledC} 2016, The Author(s).",
author = "DeRoo, {Lisa A.} and Wilcox, {Allen J} and Lie, {Rolv T} and Romitti, {Paul A.} and Pedersen, {D. A.} and Munger, {Ronald G} and {Moreno Uribe}, {Linda M.} and Wehby, {George L}",
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Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring : a large population-based pooling study. / DeRoo, Lisa A.; Wilcox, Allen J; Lie, Rolv T; Romitti, Paul A.; Pedersen, D. A.; Munger, Ronald G; Moreno Uribe, Linda M.; Wehby, George L.

I: European Journal of Epidemiology, Bind 31, Nr. 10, 2016, s. 1021-1034.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring

T2 - a large population-based pooling study

AU - DeRoo, Lisa A.

AU - Wilcox, Allen J

AU - Lie, Rolv T

AU - Romitti, Paul A.

AU - Pedersen, D. A.

AU - Munger, Ronald G

AU - Moreno Uribe, Linda M.

AU - Wehby, George L

N1 - Cited By :2 Export Date: 22 March 2017 CODEN: EJEPE

PY - 2016

Y1 - 2016

N2 - Using individual participant data from six population-based case–control studies, we conducted pooled analyses to examine maternal alcohol consumption and the risk of clefts among >4600 infants with cleft lip only, cleft lip with cleft palate, or cleft palate only and >10,000 unaffected controls. We examined two first-trimester alcohol measures: average number of drinks/sitting and maximum number of drinks/sitting, with five studies contributing to each analysis. Study-specific odds ratios (ORs) were estimated using logistic regression and pooled to generate adjusted summary ORs. Across studies, 0.9–3.2 % of control mothers reported drinking an average of 5+ drinks/sitting, while 1.4–23.5 % reported drinking a maximum of 5+ drinks/sitting. Compared with non-drinkers, mothers who drank an average of 5+ drinks/sitting were more likely to deliver an infant with cleft lip only (pooled OR 1.48; 95 % confidence intervals 1.01, 2.18). The estimate was higher among women who drank at this level 3+ times (pooled OR 1.95; 1.23, 3.11). Ever drinking a maximum of 5+ drinks/sitting and non-binge drinking were not associated with cleft risk. Repeated heavy maternal alcohol consumption was associated with an increased risk of cleft lip only in offspring. There was little evidence of increased risk for other cleft types or alcohol measures. © 2016, The Author(s).

AB - Using individual participant data from six population-based case–control studies, we conducted pooled analyses to examine maternal alcohol consumption and the risk of clefts among >4600 infants with cleft lip only, cleft lip with cleft palate, or cleft palate only and >10,000 unaffected controls. We examined two first-trimester alcohol measures: average number of drinks/sitting and maximum number of drinks/sitting, with five studies contributing to each analysis. Study-specific odds ratios (ORs) were estimated using logistic regression and pooled to generate adjusted summary ORs. Across studies, 0.9–3.2 % of control mothers reported drinking an average of 5+ drinks/sitting, while 1.4–23.5 % reported drinking a maximum of 5+ drinks/sitting. Compared with non-drinkers, mothers who drank an average of 5+ drinks/sitting were more likely to deliver an infant with cleft lip only (pooled OR 1.48; 95 % confidence intervals 1.01, 2.18). The estimate was higher among women who drank at this level 3+ times (pooled OR 1.95; 1.23, 3.11). Ever drinking a maximum of 5+ drinks/sitting and non-binge drinking were not associated with cleft risk. Repeated heavy maternal alcohol consumption was associated with an increased risk of cleft lip only in offspring. There was little evidence of increased risk for other cleft types or alcohol measures. © 2016, The Author(s).

U2 - 10.1007/s10654-016-0171-5

DO - 10.1007/s10654-016-0171-5

M3 - Journal article

C2 - 27350158

VL - 31

SP - 1021

EP - 1034

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 10

ER -