Maternal age and fetal loss: Population based register linkage study

A M Nybo Andersen, J Wohlfahrt, P Christens, Jørn Olsen, M Melbye

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE: To estimate the association between maternal age and fetal death (spontaneous abortion, ectopic pregnancy, stillbirth), taking into account a woman's reproductive history.
DESIGN: Prospective register linkage study.
SUBJECTS: All women with a reproductive outcome (live birth, stillbirth, spontaneous abortion leading to admission to hospital, induced abortion, ectopic pregnancy, or hydatidiform mole) in Denmark from 1978 to 1992; a total of 634 272 women and 1 221 546 pregnancy outcomes.
MAIN OUTCOME MEASURES: Age related risk of fetal loss, ectopic pregnancy, and stillbirth, and age related risk of spontaneous abortion stratified according to parity and previous spontaneous abortions.
RESULTS: Overall, 13.5% of the pregnancies intended to be carried to term ended with fetal loss. At age 42 years, more than half of such pregnancies resulted in fetal loss. The risk of a spontaneous abortion was 8.9% in women aged 20-24 years and 74.7% in those aged 45 years or more. High maternal age was a significant risk factor for spontaneous abortion irrespective of the number of previous miscarriages, parity, or calendar period. The risk of an ectopic pregnancy and stillbirth also increased with increasing maternal age.
CONCLUSIONS: Fetal loss is high in women in their late 30s or older, irrespective of reproductive history. This should be taken into consideration in pregnancy planning and counselling.
OriginalsprogEngelsk
TidsskriftBMJ - British Medical Journal - Clinical Research Edition
Vol/bind320
Udgave nummer7251
Sider (fra-til)1708-12
Antal sider4
ISSN0959-8138
StatusUdgivet - 24. jun. 2000
Udgivet eksterntJa

Fingeraftryk

Maternal Age
Spontaneous Abortion
Registries
Stillbirth
Ectopic Pregnancy
Reproductive History
Parity
Hydatidiform Mole
Fetal Death
Live Birth
Denmark
Counseling

Bibliografisk note

Comment in
The risks of having children in later life. Social advantage may make up for biological disadvantage. [BMJ. 2000]
Maternal age and fetal loss. Having an induced abortion increases risk in future pregnancies. [BMJ. 2001]
Maternal age and fetal loss. Data should have been stratified for smoking habit. [BMJ. 2001]
Maternal age and fetal loss. Missing abortion stratification adds to confusion. [BMJ. 2001]
ACP J Club. 2001 Jan-Feb;134(1):33.
Maternal age and fetal loss. Risks of having children in later life need to be explained. [BMJ. 2001]
Maternal age and fetal loss. Older women have increased risk of unexplained fetal deaths. [BMJ. 2001]

Citer dette

Nybo Andersen, A. M., Wohlfahrt, J., Christens, P., Olsen, J., & Melbye, M. (2000). Maternal age and fetal loss: Population based register linkage study. BMJ - British Medical Journal - Clinical Research Edition, 320(7251), 1708-12.
Nybo Andersen, A M ; Wohlfahrt, J ; Christens, P ; Olsen, Jørn ; Melbye, M. / Maternal age and fetal loss : Population based register linkage study. I: BMJ - British Medical Journal - Clinical Research Edition. 2000 ; Bind 320, Nr. 7251. s. 1708-12.
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abstract = "OBJECTIVE: To estimate the association between maternal age and fetal death (spontaneous abortion, ectopic pregnancy, stillbirth), taking into account a woman's reproductive history. DESIGN: Prospective register linkage study. SUBJECTS: All women with a reproductive outcome (live birth, stillbirth, spontaneous abortion leading to admission to hospital, induced abortion, ectopic pregnancy, or hydatidiform mole) in Denmark from 1978 to 1992; a total of 634 272 women and 1 221 546 pregnancy outcomes. MAIN OUTCOME MEASURES: Age related risk of fetal loss, ectopic pregnancy, and stillbirth, and age related risk of spontaneous abortion stratified according to parity and previous spontaneous abortions. RESULTS: Overall, 13.5{\%} of the pregnancies intended to be carried to term ended with fetal loss. At age 42 years, more than half of such pregnancies resulted in fetal loss. The risk of a spontaneous abortion was 8.9{\%} in women aged 20-24 years and 74.7{\%} in those aged 45 years or more. High maternal age was a significant risk factor for spontaneous abortion irrespective of the number of previous miscarriages, parity, or calendar period. The risk of an ectopic pregnancy and stillbirth also increased with increasing maternal age. CONCLUSIONS: Fetal loss is high in women in their late 30s or older, irrespective of reproductive history. This should be taken into consideration in pregnancy planning and counselling.",
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Nybo Andersen, AM, Wohlfahrt, J, Christens, P, Olsen, J & Melbye, M 2000, 'Maternal age and fetal loss: Population based register linkage study', BMJ - British Medical Journal - Clinical Research Edition, bind 320, nr. 7251, s. 1708-12.

Maternal age and fetal loss : Population based register linkage study. / Nybo Andersen, A M; Wohlfahrt, J; Christens, P; Olsen, Jørn; Melbye, M.

I: BMJ - British Medical Journal - Clinical Research Edition, Bind 320, Nr. 7251, 24.06.2000, s. 1708-12.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Maternal age and fetal loss

T2 - Population based register linkage study

AU - Nybo Andersen, A M

AU - Wohlfahrt, J

AU - Christens, P

AU - Olsen, Jørn

AU - Melbye, M

N1 - Comment in The risks of having children in later life. Social advantage may make up for biological disadvantage. [BMJ. 2000] Maternal age and fetal loss. Having an induced abortion increases risk in future pregnancies. [BMJ. 2001] Maternal age and fetal loss. Data should have been stratified for smoking habit. [BMJ. 2001] Maternal age and fetal loss. Missing abortion stratification adds to confusion. [BMJ. 2001] ACP J Club. 2001 Jan-Feb;134(1):33. Maternal age and fetal loss. Risks of having children in later life need to be explained. [BMJ. 2001] Maternal age and fetal loss. Older women have increased risk of unexplained fetal deaths. [BMJ. 2001]

PY - 2000/6/24

Y1 - 2000/6/24

N2 - OBJECTIVE: To estimate the association between maternal age and fetal death (spontaneous abortion, ectopic pregnancy, stillbirth), taking into account a woman's reproductive history. DESIGN: Prospective register linkage study. SUBJECTS: All women with a reproductive outcome (live birth, stillbirth, spontaneous abortion leading to admission to hospital, induced abortion, ectopic pregnancy, or hydatidiform mole) in Denmark from 1978 to 1992; a total of 634 272 women and 1 221 546 pregnancy outcomes. MAIN OUTCOME MEASURES: Age related risk of fetal loss, ectopic pregnancy, and stillbirth, and age related risk of spontaneous abortion stratified according to parity and previous spontaneous abortions. RESULTS: Overall, 13.5% of the pregnancies intended to be carried to term ended with fetal loss. At age 42 years, more than half of such pregnancies resulted in fetal loss. The risk of a spontaneous abortion was 8.9% in women aged 20-24 years and 74.7% in those aged 45 years or more. High maternal age was a significant risk factor for spontaneous abortion irrespective of the number of previous miscarriages, parity, or calendar period. The risk of an ectopic pregnancy and stillbirth also increased with increasing maternal age. CONCLUSIONS: Fetal loss is high in women in their late 30s or older, irrespective of reproductive history. This should be taken into consideration in pregnancy planning and counselling.

AB - OBJECTIVE: To estimate the association between maternal age and fetal death (spontaneous abortion, ectopic pregnancy, stillbirth), taking into account a woman's reproductive history. DESIGN: Prospective register linkage study. SUBJECTS: All women with a reproductive outcome (live birth, stillbirth, spontaneous abortion leading to admission to hospital, induced abortion, ectopic pregnancy, or hydatidiform mole) in Denmark from 1978 to 1992; a total of 634 272 women and 1 221 546 pregnancy outcomes. MAIN OUTCOME MEASURES: Age related risk of fetal loss, ectopic pregnancy, and stillbirth, and age related risk of spontaneous abortion stratified according to parity and previous spontaneous abortions. RESULTS: Overall, 13.5% of the pregnancies intended to be carried to term ended with fetal loss. At age 42 years, more than half of such pregnancies resulted in fetal loss. The risk of a spontaneous abortion was 8.9% in women aged 20-24 years and 74.7% in those aged 45 years or more. High maternal age was a significant risk factor for spontaneous abortion irrespective of the number of previous miscarriages, parity, or calendar period. The risk of an ectopic pregnancy and stillbirth also increased with increasing maternal age. CONCLUSIONS: Fetal loss is high in women in their late 30s or older, irrespective of reproductive history. This should be taken into consideration in pregnancy planning and counselling.

M3 - Journal article

C2 - 10864550

VL - 320

SP - 1708

EP - 1712

JO - B M J (Clinical Research Edition)

JF - B M J (Clinical Research Edition)

SN - 0959-8138

IS - 7251

ER -

Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M. Maternal age and fetal loss: Population based register linkage study. BMJ - British Medical Journal - Clinical Research Edition. 2000 jun 24;320(7251):1708-12.