Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond

Yanping Sun, James P Butler, Peter Lindholm, Ronn P Walvick, Stephen H Loring, Jessica Gereige, Massimo Ferrigno, Mitchell S Albert

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Oct-31
OriginalsprogEngelsk
TidsskriftRespiratory Physiology & Neurobiology
Vol/bind169
Udgave nummer1
Sider (fra-til)44-9
Antal sider5
ISSN1569-9048
DOI
StatusUdgivet - 31. okt. 2009

Fingeraftryk

Ventilation
Lung
Insufflation
Compliance

Citer dette

Sun, Yanping ; Butler, James P ; Lindholm, Peter ; Walvick, Ronn P ; Loring, Stephen H ; Gereige, Jessica ; Ferrigno, Massimo ; Albert, Mitchell S. / Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond. I: Respiratory Physiology & Neurobiology. 2009 ; Bind 169, Nr. 1. s. 44-9.
@article{747ae290010c11dfaefb000ea68e967b,
title = "Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond",
abstract = "We measured regional ventilation at 1l above functional residual capacity (FRC+1L) and total lung capacity (TLC) in three normal subjects and four elite breath-hold divers, and above TLC after glossopharyngeal insufflation (TLC+GI) in the divers. Hyperpolarized (3)He MRI was used to map the local ventilation per unit volume over the entire lung. At TLC and above, there was markedly increased regional ventilation of the lungs in the pericardial region compared with the relatively uniform ventilation throughout the rest of the lung. The distribution of fractional ventilation regionally was relatively uniform at FRC+1L, with a small non-gravitational cephalocaudal gradient of specific ventilation in the supine posture. Our observations at high lung volumes are consistent with the effect of high pleural tension in the concave pericardial region, which promotes expansion of the subjacent lung, leading to a higher local effective compliance and a higher specific ventilation.",
keywords = "Adult, Analysis of Variance, Diving, Female, Functional Residual Capacity, Helium, Humans, Isotopes, Lung, Magnetic Resonance Imaging, Male, Respiratory Mechanics, Total Lung Capacity, Young Adult",
author = "Yanping Sun and Butler, {James P} and Peter Lindholm and Walvick, {Ronn P} and Loring, {Stephen H} and Jessica Gereige and Massimo Ferrigno and Albert, {Mitchell S}",
year = "2009",
month = "10",
day = "31",
doi = "10.1016/j.resp.2009.07.024",
language = "English",
volume = "169",
pages = "44--9",
journal = "Respiratory Physiology & Neurobiology",
issn = "1569-9048",
publisher = "Elsevier",
number = "1",

}

Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond. / Sun, Yanping; Butler, James P; Lindholm, Peter; Walvick, Ronn P; Loring, Stephen H; Gereige, Jessica; Ferrigno, Massimo; Albert, Mitchell S.

I: Respiratory Physiology & Neurobiology, Bind 169, Nr. 1, 31.10.2009, s. 44-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond

AU - Sun, Yanping

AU - Butler, James P

AU - Lindholm, Peter

AU - Walvick, Ronn P

AU - Loring, Stephen H

AU - Gereige, Jessica

AU - Ferrigno, Massimo

AU - Albert, Mitchell S

PY - 2009/10/31

Y1 - 2009/10/31

N2 - We measured regional ventilation at 1l above functional residual capacity (FRC+1L) and total lung capacity (TLC) in three normal subjects and four elite breath-hold divers, and above TLC after glossopharyngeal insufflation (TLC+GI) in the divers. Hyperpolarized (3)He MRI was used to map the local ventilation per unit volume over the entire lung. At TLC and above, there was markedly increased regional ventilation of the lungs in the pericardial region compared with the relatively uniform ventilation throughout the rest of the lung. The distribution of fractional ventilation regionally was relatively uniform at FRC+1L, with a small non-gravitational cephalocaudal gradient of specific ventilation in the supine posture. Our observations at high lung volumes are consistent with the effect of high pleural tension in the concave pericardial region, which promotes expansion of the subjacent lung, leading to a higher local effective compliance and a higher specific ventilation.

AB - We measured regional ventilation at 1l above functional residual capacity (FRC+1L) and total lung capacity (TLC) in three normal subjects and four elite breath-hold divers, and above TLC after glossopharyngeal insufflation (TLC+GI) in the divers. Hyperpolarized (3)He MRI was used to map the local ventilation per unit volume over the entire lung. At TLC and above, there was markedly increased regional ventilation of the lungs in the pericardial region compared with the relatively uniform ventilation throughout the rest of the lung. The distribution of fractional ventilation regionally was relatively uniform at FRC+1L, with a small non-gravitational cephalocaudal gradient of specific ventilation in the supine posture. Our observations at high lung volumes are consistent with the effect of high pleural tension in the concave pericardial region, which promotes expansion of the subjacent lung, leading to a higher local effective compliance and a higher specific ventilation.

KW - Adult

KW - Analysis of Variance

KW - Diving

KW - Female

KW - Functional Residual Capacity

KW - Helium

KW - Humans

KW - Isotopes

KW - Lung

KW - Magnetic Resonance Imaging

KW - Male

KW - Respiratory Mechanics

KW - Total Lung Capacity

KW - Young Adult

U2 - 10.1016/j.resp.2009.07.024

DO - 10.1016/j.resp.2009.07.024

M3 - Journal article

C2 - 19664729

VL - 169

SP - 44

EP - 49

JO - Respiratory Physiology & Neurobiology

JF - Respiratory Physiology & Neurobiology

SN - 1569-9048

IS - 1

ER -