MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

B-C Sondergaard; N Schultz; S H Madsen; A-C Bay-Jensen; M Kassem; M A Karsdal

doi:10.1016/j.joca.2009.11.005

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

B-C Sondergaard
, N Schultz
, S H Madsen
, A-C Bay-Jensen
, M Kassem
, M A Karsdal

Nordic Bioscience

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Matrix metalloproteinases (MMPs) and aggrecanases are essential players in cartilage degradation. However, the signaling pathways that results in MMP and/or aggrecanase synthesis and activation are not well understood. We investigated the molecular events leading to MMP- and aggrecanase-mediated cartilage degradation.

Originalsprog	Engelsk
Tidsskrift	Osteoarthritis and Cartilage
Vol/bind	18
Udgave nummer	3
Sider (fra-til)	279-88
Antal sider	10
ISSN	1063-4584
DOI	https://doi.org/10.1016/j.joca.2009.11.005
Status	Udgivet - 1. mar. 2010

Dokumenter og links

10.1016/j.joca.2009.11.005

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

Sondergaard, B.-C., Schultz, N., Madsen, S. H., Bay-Jensen, A.-C., Kassem, M., & Karsdal, M. A. (2010). MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. Osteoarthritis and Cartilage, 18(3), 279-88. https://doi.org/10.1016/j.joca.2009.11.005

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abstract = "Matrix metalloproteinases (MMPs) and aggrecanases are essential players in cartilage degradation. However, the signaling pathways that results in MMP and/or aggrecanase synthesis and activation are not well understood. We investigated the molecular events leading to MMP- and aggrecanase-mediated cartilage degradation.",

keywords = "Animals, Cartilage, Articular, Cattle, Dose-Response Relationship, Drug, Endopeptidases, Matrix Metalloproteinases, Osteoarthritis, Signal Transduction, Statistics as Topic",

author = "B-C Sondergaard and N Schultz and Madsen, \{S H\} and A-C Bay-Jensen and M Kassem and Karsdal, \{M A\}",

year = "2010",

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doi = "10.1016/j.joca.2009.11.005",

language = "English",

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Sondergaard, B-C, Schultz, N, Madsen, SH, Bay-Jensen, A-C, Kassem, M & Karsdal, MA 2010, 'MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation', Osteoarthritis and Cartilage, bind 18, nr. 3, s. 279-88. https://doi.org/10.1016/j.joca.2009.11.005

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. / Sondergaard, B-C; Schultz, N; Madsen, S H et al.
I: Osteoarthritis and Cartilage, Bind 18, Nr. 3, 01.03.2010, s. 279-88.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

AU - Sondergaard, B-C

AU - Schultz, N

AU - Madsen, S H

AU - Bay-Jensen, A-C

AU - Kassem, M

AU - Karsdal, M A

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Matrix metalloproteinases (MMPs) and aggrecanases are essential players in cartilage degradation. However, the signaling pathways that results in MMP and/or aggrecanase synthesis and activation are not well understood. We investigated the molecular events leading to MMP- and aggrecanase-mediated cartilage degradation.

AB - Matrix metalloproteinases (MMPs) and aggrecanases are essential players in cartilage degradation. However, the signaling pathways that results in MMP and/or aggrecanase synthesis and activation are not well understood. We investigated the molecular events leading to MMP- and aggrecanase-mediated cartilage degradation.

KW - Animals

KW - Cartilage, Articular

KW - Cattle

KW - Dose-Response Relationship, Drug

KW - Endopeptidases

KW - Matrix Metalloproteinases

KW - Osteoarthritis

KW - Signal Transduction

KW - Statistics as Topic

U2 - 10.1016/j.joca.2009.11.005

DO - 10.1016/j.joca.2009.11.005

M3 - Journal article

C2 - 19932675

SN - 1063-4584

VL - 18

SP - 279

EP - 288

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 3

ER -

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

Abstract

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SDU link

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Citationsformater