Manglende effekt af nortriptylin hos en hurtig omdanner af spartein.

K. B. Stage*, K. Brøsen

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Abstrakt

A 61-year old woman suffering from depression was treated with 150 mg nortriptyline daily for eight weeks by her general practitioner. In spite of this dose, her S-nortriptyline was only 100 nmol/1 (recommended range: 225-600 nmol/1), and she remained depressed and was admitted to hospital. A sparteine test gave a metabolic ratio of 0.06, hence the patient was classified as a very rapid extensive metabolizer. Her nortriptyline dose was increased to 250 mg/day and the S-nortriptyline rose to 528 nmol/l. After eight weeks of sufficient nortriptyline treatment, the patient was still depressed. The patient recovered completely after a series of five electroconvulsive treatments.

Bidragets oversatte titelInsufficient effect of nortriptyline in a rapid metabolizer of sparteine
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind155
Udgave nummer20
Sider (fra-til)1561-1563
Antal sider3
ISSN0041-5782
StatusUdgivet - 17. maj 1993

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