Lower mortality and cardiovascular event rates in patients with latent autoimmune diabetes in adults (LADA) as compared with type 2 diabetes and insulin deficient diabetes: A Cohort Study of 4,368 Patients.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

94 Downloads (Pure)

Resumé

Background: Latent Autoimmune Diabetes in Adults (LADA) is the second most common form of diabetes, but data on its clinical course and prognosis are scarce. We compared long-term risk of mortality and cardiovascular outcomes in patients with LADA, type 2 diabetes mellitus (T2D), and insulin deficient diabetes (IDD). Methods: We conducted a cohort study of 4368 adults with diabetes referred to the Department of Endocrinology, Odense University Hospital, Denmark, between 1997 and 2012. Data on comorbidity, cardiovascular outcomes and death were obtained from prospective medical databases. We compared adjusted hazard ratios (HRs) of mortality and cardiovascular outcomes for patients with LADA, T2D and IDD, respectively. Results: We included 327 patients with LADA, 3539 with T2D and 502 with IDD. At diagnosis, patients with LADA were older (50 years (IQR 37–59)) than IDD patients (40 years (IQR 28–52)), but younger than patients with T2D (55 years (IQR 45–64)). During a median follow-up period of 6.6 years (IQR 3.4–9.4), patients with IDD had higher mortality than patients with LADA, age- and gender-adjusted HR 2.2 (95% CI, 1.5–3.2). T2D also conferred higher mortality than LADA, HR 1.4 (95% CI, 1.0–1.9). Compared with LADA patients, cardiovascular outcome rates were increased both with IDD, HR 1.2 (95% CI, 0.7–2.0) and T2D, HR 1.2 (95% CI, 0.8–1.8), with the strongest association observed for T2D vs. LADA and acute myocardial infarction HR 1.7 (95% CI, 0.8–3.5). Conclusion: LADA seems to be associated with lower mortality and lower risk of cardiovascular events, compared with both T2D and IDD.

OriginalsprogEngelsk
TidsskriftDiabetes Research and Clinical Practice
Vol/bind139
Sider (fra-til)107–113
ISSN0168-8227
DOI
StatusUdgivet - maj 2018

Fingeraftryk

Type 2 Diabetes Mellitus
Cohort Studies
Insulin
Latent Autoimmune Diabetes in Adults
Endocrinology
Denmark
Comorbidity
Databases

Emneord

  • Latent Autoimmune Diabetes in Adults

Citer dette

@article{4bb2865f6e7b4d5f82bbd5e97d26b65d,
title = "Lower mortality and cardiovascular event rates in patients with latent autoimmune diabetes in adults (LADA) as compared with type 2 diabetes and insulin deficient diabetes: A Cohort Study of 4,368 Patients.",
abstract = "Background: Latent Autoimmune Diabetes in Adults (LADA) is the second most common form of diabetes, but data on its clinical course and prognosis are scarce. We compared long-term risk of mortality and cardiovascular outcomes in patients with LADA, type 2 diabetes mellitus (T2D), and insulin deficient diabetes (IDD). Methods: We conducted a cohort study of 4368 adults with diabetes referred to the Department of Endocrinology, Odense University Hospital, Denmark, between 1997 and 2012. Data on comorbidity, cardiovascular outcomes and death were obtained from prospective medical databases. We compared adjusted hazard ratios (HRs) of mortality and cardiovascular outcomes for patients with LADA, T2D and IDD, respectively. Results: We included 327 patients with LADA, 3539 with T2D and 502 with IDD. At diagnosis, patients with LADA were older (50 years (IQR 37–59)) than IDD patients (40 years (IQR 28–52)), but younger than patients with T2D (55 years (IQR 45–64)). During a median follow-up period of 6.6 years (IQR 3.4–9.4), patients with IDD had higher mortality than patients with LADA, age- and gender-adjusted HR 2.2 (95{\%} CI, 1.5–3.2). T2D also conferred higher mortality than LADA, HR 1.4 (95{\%} CI, 1.0–1.9). Compared with LADA patients, cardiovascular outcome rates were increased both with IDD, HR 1.2 (95{\%} CI, 0.7–2.0) and T2D, HR 1.2 (95{\%} CI, 0.8–1.8), with the strongest association observed for T2D vs. LADA and acute myocardial infarction HR 1.7 (95{\%} CI, 0.8–3.5). Conclusion: LADA seems to be associated with lower mortality and lower risk of cardiovascular events, compared with both T2D and IDD.",
keywords = "Latent Autoimmune Diabetes in Adults, LADA, Mortality, Outcomes, Cardiovascular Diseases, Prospective Studies, Humans, Middle Aged, Male, Treatment Outcome, Diabetes Mellitus, Type 2/complications, Latent Autoimmune Diabetes in Adults/complications, Survival Analysis, Adult, Female, Cohort Studies",
author = "Mette Wod and Thomsen, {Reimar Wernich} and Yderstr{\ae}de, {Knud Bonnet} and Henning Beck-Nielsen and Kurt H{\o}jlund and L. Pedersen",
year = "2018",
month = "5",
doi = "10.1016/j.diabres.2018.02.042",
language = "English",
volume = "139",
pages = "107–113",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier",

}

TY - JOUR

T1 - Lower mortality and cardiovascular event rates in patients with latent autoimmune diabetes in adults (LADA) as compared with type 2 diabetes and insulin deficient diabetes: A Cohort Study of 4,368 Patients.

AU - Wod, Mette

AU - Thomsen, Reimar Wernich

AU - Yderstræde, Knud Bonnet

AU - Beck-Nielsen, Henning

AU - Højlund, Kurt

AU - Pedersen, L.

PY - 2018/5

Y1 - 2018/5

N2 - Background: Latent Autoimmune Diabetes in Adults (LADA) is the second most common form of diabetes, but data on its clinical course and prognosis are scarce. We compared long-term risk of mortality and cardiovascular outcomes in patients with LADA, type 2 diabetes mellitus (T2D), and insulin deficient diabetes (IDD). Methods: We conducted a cohort study of 4368 adults with diabetes referred to the Department of Endocrinology, Odense University Hospital, Denmark, between 1997 and 2012. Data on comorbidity, cardiovascular outcomes and death were obtained from prospective medical databases. We compared adjusted hazard ratios (HRs) of mortality and cardiovascular outcomes for patients with LADA, T2D and IDD, respectively. Results: We included 327 patients with LADA, 3539 with T2D and 502 with IDD. At diagnosis, patients with LADA were older (50 years (IQR 37–59)) than IDD patients (40 years (IQR 28–52)), but younger than patients with T2D (55 years (IQR 45–64)). During a median follow-up period of 6.6 years (IQR 3.4–9.4), patients with IDD had higher mortality than patients with LADA, age- and gender-adjusted HR 2.2 (95% CI, 1.5–3.2). T2D also conferred higher mortality than LADA, HR 1.4 (95% CI, 1.0–1.9). Compared with LADA patients, cardiovascular outcome rates were increased both with IDD, HR 1.2 (95% CI, 0.7–2.0) and T2D, HR 1.2 (95% CI, 0.8–1.8), with the strongest association observed for T2D vs. LADA and acute myocardial infarction HR 1.7 (95% CI, 0.8–3.5). Conclusion: LADA seems to be associated with lower mortality and lower risk of cardiovascular events, compared with both T2D and IDD.

AB - Background: Latent Autoimmune Diabetes in Adults (LADA) is the second most common form of diabetes, but data on its clinical course and prognosis are scarce. We compared long-term risk of mortality and cardiovascular outcomes in patients with LADA, type 2 diabetes mellitus (T2D), and insulin deficient diabetes (IDD). Methods: We conducted a cohort study of 4368 adults with diabetes referred to the Department of Endocrinology, Odense University Hospital, Denmark, between 1997 and 2012. Data on comorbidity, cardiovascular outcomes and death were obtained from prospective medical databases. We compared adjusted hazard ratios (HRs) of mortality and cardiovascular outcomes for patients with LADA, T2D and IDD, respectively. Results: We included 327 patients with LADA, 3539 with T2D and 502 with IDD. At diagnosis, patients with LADA were older (50 years (IQR 37–59)) than IDD patients (40 years (IQR 28–52)), but younger than patients with T2D (55 years (IQR 45–64)). During a median follow-up period of 6.6 years (IQR 3.4–9.4), patients with IDD had higher mortality than patients with LADA, age- and gender-adjusted HR 2.2 (95% CI, 1.5–3.2). T2D also conferred higher mortality than LADA, HR 1.4 (95% CI, 1.0–1.9). Compared with LADA patients, cardiovascular outcome rates were increased both with IDD, HR 1.2 (95% CI, 0.7–2.0) and T2D, HR 1.2 (95% CI, 0.8–1.8), with the strongest association observed for T2D vs. LADA and acute myocardial infarction HR 1.7 (95% CI, 0.8–3.5). Conclusion: LADA seems to be associated with lower mortality and lower risk of cardiovascular events, compared with both T2D and IDD.

KW - Latent Autoimmune Diabetes in Adults

KW - LADA

KW - Mortality

KW - Outcomes

KW - Cardiovascular Diseases

KW - Prospective Studies

KW - Humans

KW - Middle Aged

KW - Male

KW - Treatment Outcome

KW - Diabetes Mellitus, Type 2/complications

KW - Latent Autoimmune Diabetes in Adults/complications

KW - Survival Analysis

KW - Adult

KW - Female

KW - Cohort Studies

U2 - 10.1016/j.diabres.2018.02.042

DO - 10.1016/j.diabres.2018.02.042

M3 - Journal article

C2 - 29518492

VL - 139

SP - 107

EP - 113

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

ER -