Longitudinal study of sexual function and vaginal changes after radiotherapy for cervical cancer

Pernille T Jensen, Mogens Groenvold, Marianne C Klee, Ingrid Thranov, Morten A Petersen, David Machin

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

PURPOSE: To investigate the longitudinal course of self-reported sexual function and vaginal changes in patients disease free after radiotherapy (RT) for locally advanced, recurrent, or persistent cervical cancer.

MATERIALS AND METHODS: A total of 118 patients referred for RT were included. The patients were assessed, using a validated self-assessment questionnaire, at the termination of RT and 1, 3, 6, 12, 18, and 24 months later. The results were compared with an age-matched control group from the general population.

RESULTS: Persistent sexual dysfunction and adverse vaginal changes were reported throughout the 2 years after RT, with small changes over time: approximately 85% had low or no sexual interest, 35% had moderate to severe lack of lubrication, 55% had mild to severe dyspareunia, and 30% were dissatisfied with their sexual life. A reduced vaginal dimension was reported by 50% of the patients, and 45% were never, or only occasionally, able to complete sexual intercourse. Despite sexual dysfunction and vaginal adverse effects, 63% of those sexually active before having cancer remained sexually active after treatment, although with a considerably decreased frequency.

CONCLUSIONS: Patients who are disease free after RT for locally advanced, recurrent, or persistent cervical cancer are at high risk of experiencing persistent sexual and vaginal problems compromising their sexual activity and satisfaction.

OriginalsprogEngelsk
TidsskriftInternational Journal of Radiation Oncology, Biology, Physics
Vol/bind56
Udgave nummer4
Sider (fra-til)937-49
Antal sider13
ISSN0360-3016
StatusUdgivet - 15. jul. 2003

Fingeraftryk

Uterine Cervical Neoplasms
Longitudinal Studies
radiation therapy
cancer
Orgasm
Lubrication
Dyspareunia
lubrication
Sexual Behavior
Research Design
Control Groups
Population
Neoplasms

Citer dette

Jensen, Pernille T ; Groenvold, Mogens ; Klee, Marianne C ; Thranov, Ingrid ; Petersen, Morten A ; Machin, David. / Longitudinal study of sexual function and vaginal changes after radiotherapy for cervical cancer. I: International Journal of Radiation Oncology, Biology, Physics. 2003 ; Bind 56, Nr. 4. s. 937-49.
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Longitudinal study of sexual function and vaginal changes after radiotherapy for cervical cancer. / Jensen, Pernille T; Groenvold, Mogens; Klee, Marianne C; Thranov, Ingrid; Petersen, Morten A; Machin, David.

I: International Journal of Radiation Oncology, Biology, Physics, Bind 56, Nr. 4, 15.07.2003, s. 937-49.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Longitudinal study of sexual function and vaginal changes after radiotherapy for cervical cancer

AU - Jensen, Pernille T

AU - Groenvold, Mogens

AU - Klee, Marianne C

AU - Thranov, Ingrid

AU - Petersen, Morten A

AU - Machin, David

PY - 2003/7/15

Y1 - 2003/7/15

N2 - PURPOSE: To investigate the longitudinal course of self-reported sexual function and vaginal changes in patients disease free after radiotherapy (RT) for locally advanced, recurrent, or persistent cervical cancer.MATERIALS AND METHODS: A total of 118 patients referred for RT were included. The patients were assessed, using a validated self-assessment questionnaire, at the termination of RT and 1, 3, 6, 12, 18, and 24 months later. The results were compared with an age-matched control group from the general population.RESULTS: Persistent sexual dysfunction and adverse vaginal changes were reported throughout the 2 years after RT, with small changes over time: approximately 85% had low or no sexual interest, 35% had moderate to severe lack of lubrication, 55% had mild to severe dyspareunia, and 30% were dissatisfied with their sexual life. A reduced vaginal dimension was reported by 50% of the patients, and 45% were never, or only occasionally, able to complete sexual intercourse. Despite sexual dysfunction and vaginal adverse effects, 63% of those sexually active before having cancer remained sexually active after treatment, although with a considerably decreased frequency.CONCLUSIONS: Patients who are disease free after RT for locally advanced, recurrent, or persistent cervical cancer are at high risk of experiencing persistent sexual and vaginal problems compromising their sexual activity and satisfaction.

AB - PURPOSE: To investigate the longitudinal course of self-reported sexual function and vaginal changes in patients disease free after radiotherapy (RT) for locally advanced, recurrent, or persistent cervical cancer.MATERIALS AND METHODS: A total of 118 patients referred for RT were included. The patients were assessed, using a validated self-assessment questionnaire, at the termination of RT and 1, 3, 6, 12, 18, and 24 months later. The results were compared with an age-matched control group from the general population.RESULTS: Persistent sexual dysfunction and adverse vaginal changes were reported throughout the 2 years after RT, with small changes over time: approximately 85% had low or no sexual interest, 35% had moderate to severe lack of lubrication, 55% had mild to severe dyspareunia, and 30% were dissatisfied with their sexual life. A reduced vaginal dimension was reported by 50% of the patients, and 45% were never, or only occasionally, able to complete sexual intercourse. Despite sexual dysfunction and vaginal adverse effects, 63% of those sexually active before having cancer remained sexually active after treatment, although with a considerably decreased frequency.CONCLUSIONS: Patients who are disease free after RT for locally advanced, recurrent, or persistent cervical cancer are at high risk of experiencing persistent sexual and vaginal problems compromising their sexual activity and satisfaction.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Quality of Life

KW - Radiation Injuries

KW - Sexual Behavior

KW - Sexual Dysfunction, Physiological

KW - Surveys and Questionnaires

KW - Uterine Cervical Neoplasms

KW - Vagina

KW - Vaginal Neoplasms

M3 - Journal article

VL - 56

SP - 937

EP - 949

JO - International Journal of Radiation Oncology, Biology, Physics

JF - International Journal of Radiation Oncology, Biology, Physics

SN - 0360-3016

IS - 4

ER -