Longitudinal Retinal Changes in MOGAD

Frederike Cosima Oertel, Elias S. Sotirchos, Hanna G. Zimmermann, Seyedamirhosein Motamedi, Svenja Specovius, Eva Susanna Asseyer, Claudia Chien, Lawrence Cook, Eleni Vasileiou, Angeliki Filippatou, Peter A. Calabresi, Shiv Saidha, Lekha Pandit, Anitha D'Cunha, Olivier Outteryck, Hélène Zéphir, Sean Pittock, Eoin P. Flanagan, M. Tariq Bhatti, Paulus S. RommerGabriel Bsteh, Tobias Zrzavy, Tania Kuempfel, Orhan Aktas, Marius Ringelstein, Philipp Albrecht, Ilya Ayzenberg, Thivya Pakeerathan, Benjamin Knier, Lilian Aly, Nasrin Asgari, Kerstin Soelberg, Romain Marignier, Caroline Froment Tilikete, Alvaro Cobo Calvo, Pablo Villoslada, Bernardo Sanchez-Dalmau, Elena H. Martinez-Lapiscina, Sara Llufriu, Ari J. Green, Michael R. Yeaman, Terry J. Smith, Alexander U. Brandt, John Chen, Friedemann Paul*, Joachim Havla, with the GJCF International Clinical Consortium for NMOSD and the CROCTINO study group

*Kontaktforfatter for dette arbejde

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Abstrakt

OBJECTIVE: Patients with myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro-axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON-independent retinal atrophy can be detected in MOGAD.

METHODS: Eighty patients with MOGAD and 139 healthy controls (HCs) were included. OCT data was acquired with (1) Spectralis spectral domain OCT (MOGAD: N = 66 and HCs: N = 103) and (2) Cirrus high-definition OCT (MOGAD: N = 14 and HCs: N = 36). Macular combined ganglion cell and inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) were quantified.

RESULTS: At baseline, GCIPL and pRNFL were lower in MOGAD eyes with a history of ON (MOGAD-ON) compared with MOGAD eyes without a history of ON (MOGAD-NON) and HCs (p < 0.001). MOGAD-NON eyes had lower GCIPL volume compared to HCs (p < 0.001) in the Spectralis, but not in the Cirrus cohort. Longitudinally (follow-up up to 3 years), MOGAD-ON with ON within the last 6-12 months before baseline exhibited greater pRNFL thinning than MOGAD-ON with an ON greater than 12 months ago (p < 0.001). The overall MOGAD cohort did not exhibit faster GCIPL thinning compared with the HC cohort.

INTERPRETATION: Our study suggests the absence of attack-independent retinal damage in patients with MOGAD. Yet, ongoing neuroaxonal damage or edema resolution seems to occur for up to 12 months after ON, which is longer than what has been reported with other ON forms. These findings support that the pathomechanisms underlying optic nerve involvement and the evolution of OCT retinal changes after ON is distinct in patients with MOGAD. ANN NEUROL 2022;92:476-485.

OriginalsprogEngelsk
TidsskriftAnnals of Neurology
Vol/bind92
Udgave nummer3
Sider (fra-til)476-485
ISSN0364-5134
DOI
StatusUdgivet - sep. 2022

Bibliografisk note

Funding Information:
J.H. and F.C.O. would like to thank Charlotte Bereuter, Angelika Bamberger, and Luise Böhm for their excellent technical support. This study was funded in part by the Guthy‐Jackson Charitable Foundation. J.H. is (partially) funded by the German Federal Ministry of Education and Research (Grant Numbers 01ZZ1603[A‐D] and 01ZZ1804[A‐H] DIFUTURE). F.C.O. received research support by the German Association of Neurology (Deutsche Gesellschaft für Neurologie) in context of this work and would like to thank the American Academy of Neurology (AAN) and the National Multiple Sclerosis Society (NMSS) for their research support. Open Access funding enabled and organized by Projekt DEAL.

Publisher Copyright:
© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

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