Longitudinal relationship between inflammatory markers in adolescents and childhood fatness, fitness and physical activity

Anna Bugge, Bianca El-Naaman Hermansen, Karsten Froberg, Robert G McMurray, Lars Bo Andersen

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

Resumé

Low-grade inflammation may provide a mechanism linking obesity with cardiometabolic diseases and is also related to aerobic fitness (VO2max) and physical activity (PA). However, the longitudinal associations between these factors over the course of childhood and young adolescence are yet to be elucidated.
PURPOSE: To determine if fatness and exercise during childhood is related to level of inflammation during adolescence. METHODS: Subjects for this longitudinal study were 387, 6 year old children followed for 7 years, obtained from 18 schools near Copenhagen. Sum of 4 skinfolds (S4SF) was measured. PA was measured for four consecutive days (Actigraph). VO2max was directly measured. Fasting blood samples were analyzed for inflammatory markers. RESULTS: Significant correlations were found between S4SF at age 6 and C-reactive protein (CRP) level at age 13 for both boys and girls (r=0.330 and 0.293 respectively, p=0.0001). S4SF at age 6 was related to interleukin-6 (IL6) level at age 13 only for boys (r=0.165, p=0.019). Children in the highest tertile of S4SF at age 6 had an odds ratio of 3.68 (p=0.0001) being in the highest tertile of CRP at age 13, compared to the lowest tertile. VO2max at age 6 was inversely related to CRP level at age 13 only for girls (r=-0.172, p=0.025) and not significantly related to IL-6 in either sex (p>0.05). Conversely children in the two lowest tertiles of VO2max at age 6 had odds ratios of 1.83 and 1.97 (p=0.046 & 0.022, respectively) for being in the highest tertile of IL6 at age 13. No correlations were found between PA and any inflammatory markers, but children in the highest tertile of PA at age 6 had an odds ratio of 1.81 (p=0.042) being in the highest tertile of IL-6 at age 13. CONCLUSION: This study supports previous findings that fatness and VO2max are related to CRP; whereas, IL-6 only correlated to fatness in boys. Furthermore we found that children in the highest tertile of PA at age 6 had the greatest risk of being in the highest tertile of IL-6 at age 13, which emphasizes the controversial role of IL-6. Our results indicates that childhood levels of fatness and fitness impacts the level of some but not all inflammatory markers in adolescents, and therefore should be targeted in cardio vascular disease prevention strategies.
Supported by The Danish Heart Foundation

OriginalsprogEngelsk
Publikationsdato3. jun. 2011
Antal sider1
StatusUdgivet - 3. jun. 2011
BegivenhedACSM Annual meeting 2011 - Denver, USA
Varighed: 30. maj 20114. jun. 2011

Konference

KonferenceACSM Annual meeting 2011
LandUSA
ByDenver
Periode30/05/201104/06/2011

Citer dette

Bugge, A., Hermansen, B. E-N., Froberg, K., McMurray, R. G., & Andersen, L. B. (2011). Longitudinal relationship between inflammatory markers in adolescents and childhood fatness, fitness and physical activity. Poster session præsenteret på ACSM Annual meeting 2011, Denver, USA.
Bugge, Anna ; Hermansen, Bianca El-Naaman ; Froberg, Karsten ; McMurray, Robert G ; Andersen, Lars Bo. / Longitudinal relationship between inflammatory markers in adolescents and childhood fatness, fitness and physical activity. Poster session præsenteret på ACSM Annual meeting 2011, Denver, USA.1 s.
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title = "Longitudinal relationship between inflammatory markers in adolescents and childhood fatness, fitness and physical activity",
abstract = "Low-grade inflammation may provide a mechanism linking obesity with cardiometabolic diseases and is also related to aerobic fitness (VO2max) and physical activity (PA). However, the longitudinal associations between these factors over the course of childhood and young adolescence are yet to be elucidated. PURPOSE: To determine if fatness and exercise during childhood is related to level of inflammation during adolescence. METHODS: Subjects for this longitudinal study were 387, 6 year old children followed for 7 years, obtained from 18 schools near Copenhagen. Sum of 4 skinfolds (S4SF) was measured. PA was measured for four consecutive days (Actigraph). VO2max was directly measured. Fasting blood samples were analyzed for inflammatory markers. RESULTS: Significant correlations were found between S4SF at age 6 and C-reactive protein (CRP) level at age 13 for both boys and girls (r=0.330 and 0.293 respectively, p=0.0001). S4SF at age 6 was related to interleukin-6 (IL6) level at age 13 only for boys (r=0.165, p=0.019). Children in the highest tertile of S4SF at age 6 had an odds ratio of 3.68 (p=0.0001) being in the highest tertile of CRP at age 13, compared to the lowest tertile. VO2max at age 6 was inversely related to CRP level at age 13 only for girls (r=-0.172, p=0.025) and not significantly related to IL-6 in either sex (p>0.05). Conversely children in the two lowest tertiles of VO2max at age 6 had odds ratios of 1.83 and 1.97 (p=0.046 & 0.022, respectively) for being in the highest tertile of IL6 at age 13. No correlations were found between PA and any inflammatory markers, but children in the highest tertile of PA at age 6 had an odds ratio of 1.81 (p=0.042) being in the highest tertile of IL-6 at age 13. CONCLUSION: This study supports previous findings that fatness and VO2max are related to CRP; whereas, IL-6 only correlated to fatness in boys. Furthermore we found that children in the highest tertile of PA at age 6 had the greatest risk of being in the highest tertile of IL-6 at age 13, which emphasizes the controversial role of IL-6. Our results indicates that childhood levels of fatness and fitness impacts the level of some but not all inflammatory markers in adolescents, and therefore should be targeted in cardio vascular disease prevention strategies. Supported by The Danish Heart Foundation",
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Bugge, A, Hermansen, BE-N, Froberg, K, McMurray, RG & Andersen, LB 2011, 'Longitudinal relationship between inflammatory markers in adolescents and childhood fatness, fitness and physical activity', ACSM Annual meeting 2011, Denver, USA, 30/05/2011 - 04/06/2011.

Longitudinal relationship between inflammatory markers in adolescents and childhood fatness, fitness and physical activity. / Bugge, Anna; Hermansen, Bianca El-Naaman; Froberg, Karsten; McMurray, Robert G; Andersen, Lars Bo.

2011. Poster session præsenteret på ACSM Annual meeting 2011, Denver, USA.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

TY - CONF

T1 - Longitudinal relationship between inflammatory markers in adolescents and childhood fatness, fitness and physical activity

AU - Bugge, Anna

AU - Hermansen, Bianca El-Naaman

AU - Froberg, Karsten

AU - McMurray, Robert G

AU - Andersen, Lars Bo

PY - 2011/6/3

Y1 - 2011/6/3

N2 - Low-grade inflammation may provide a mechanism linking obesity with cardiometabolic diseases and is also related to aerobic fitness (VO2max) and physical activity (PA). However, the longitudinal associations between these factors over the course of childhood and young adolescence are yet to be elucidated. PURPOSE: To determine if fatness and exercise during childhood is related to level of inflammation during adolescence. METHODS: Subjects for this longitudinal study were 387, 6 year old children followed for 7 years, obtained from 18 schools near Copenhagen. Sum of 4 skinfolds (S4SF) was measured. PA was measured for four consecutive days (Actigraph). VO2max was directly measured. Fasting blood samples were analyzed for inflammatory markers. RESULTS: Significant correlations were found between S4SF at age 6 and C-reactive protein (CRP) level at age 13 for both boys and girls (r=0.330 and 0.293 respectively, p=0.0001). S4SF at age 6 was related to interleukin-6 (IL6) level at age 13 only for boys (r=0.165, p=0.019). Children in the highest tertile of S4SF at age 6 had an odds ratio of 3.68 (p=0.0001) being in the highest tertile of CRP at age 13, compared to the lowest tertile. VO2max at age 6 was inversely related to CRP level at age 13 only for girls (r=-0.172, p=0.025) and not significantly related to IL-6 in either sex (p>0.05). Conversely children in the two lowest tertiles of VO2max at age 6 had odds ratios of 1.83 and 1.97 (p=0.046 & 0.022, respectively) for being in the highest tertile of IL6 at age 13. No correlations were found between PA and any inflammatory markers, but children in the highest tertile of PA at age 6 had an odds ratio of 1.81 (p=0.042) being in the highest tertile of IL-6 at age 13. CONCLUSION: This study supports previous findings that fatness and VO2max are related to CRP; whereas, IL-6 only correlated to fatness in boys. Furthermore we found that children in the highest tertile of PA at age 6 had the greatest risk of being in the highest tertile of IL-6 at age 13, which emphasizes the controversial role of IL-6. Our results indicates that childhood levels of fatness and fitness impacts the level of some but not all inflammatory markers in adolescents, and therefore should be targeted in cardio vascular disease prevention strategies. Supported by The Danish Heart Foundation

AB - Low-grade inflammation may provide a mechanism linking obesity with cardiometabolic diseases and is also related to aerobic fitness (VO2max) and physical activity (PA). However, the longitudinal associations between these factors over the course of childhood and young adolescence are yet to be elucidated. PURPOSE: To determine if fatness and exercise during childhood is related to level of inflammation during adolescence. METHODS: Subjects for this longitudinal study were 387, 6 year old children followed for 7 years, obtained from 18 schools near Copenhagen. Sum of 4 skinfolds (S4SF) was measured. PA was measured for four consecutive days (Actigraph). VO2max was directly measured. Fasting blood samples were analyzed for inflammatory markers. RESULTS: Significant correlations were found between S4SF at age 6 and C-reactive protein (CRP) level at age 13 for both boys and girls (r=0.330 and 0.293 respectively, p=0.0001). S4SF at age 6 was related to interleukin-6 (IL6) level at age 13 only for boys (r=0.165, p=0.019). Children in the highest tertile of S4SF at age 6 had an odds ratio of 3.68 (p=0.0001) being in the highest tertile of CRP at age 13, compared to the lowest tertile. VO2max at age 6 was inversely related to CRP level at age 13 only for girls (r=-0.172, p=0.025) and not significantly related to IL-6 in either sex (p>0.05). Conversely children in the two lowest tertiles of VO2max at age 6 had odds ratios of 1.83 and 1.97 (p=0.046 & 0.022, respectively) for being in the highest tertile of IL6 at age 13. No correlations were found between PA and any inflammatory markers, but children in the highest tertile of PA at age 6 had an odds ratio of 1.81 (p=0.042) being in the highest tertile of IL-6 at age 13. CONCLUSION: This study supports previous findings that fatness and VO2max are related to CRP; whereas, IL-6 only correlated to fatness in boys. Furthermore we found that children in the highest tertile of PA at age 6 had the greatest risk of being in the highest tertile of IL-6 at age 13, which emphasizes the controversial role of IL-6. Our results indicates that childhood levels of fatness and fitness impacts the level of some but not all inflammatory markers in adolescents, and therefore should be targeted in cardio vascular disease prevention strategies. Supported by The Danish Heart Foundation

M3 - Poster

ER -

Bugge A, Hermansen BE-N, Froberg K, McMurray RG, Andersen LB. Longitudinal relationship between inflammatory markers in adolescents and childhood fatness, fitness and physical activity. 2011. Poster session præsenteret på ACSM Annual meeting 2011, Denver, USA.