Long-term use of lithium and risk of colorectal adenocarcinoma: a nationwide case-control study

Anton Pottegård, Zandra Nymand Ennis, Jesper Hallas, Boye L Jensen, Kirsten Madsen, Søren Friis

Publikation: Bidrag til tidsskriftLetterForskningpeer review

Resumé

BACKGROUND: Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study.

METHODS: We used the Danish Cancer Registry to identify all patients diagnosed with incident colorectal adenocarcinoma during 2000-2012 (n=36 248). Using a matched case-control approach, we estimated the association between long-term use (⩾5 years) of lithium and risk of colorectal adenocarcinoma using conditional logistic regression.

RESULTS: Long-term use of lithium was similar among cases (0.22%) and controls (0.20%), yielding an odds ratio of 1.13 (95% confidence interval (CI), 0.89-1.43) for colorectal adenocarcinoma. Dose-response, subgroup and other subanalyses returned neutral associations. However, ORs differed for colorectal subsites (proximal colon: 1.01 (95% CI, 0.66-1.55; distal colon: 1.52 (95% CI, 1.05-2.20); and rectum: 0.80 (95% CI, 0.50-1.30).

CONCLUSIONS: Lithium use was not associated with an overall increased risk of colorectal adenocarcinoma. The variation by subsite warrants further investigation.

OriginalsprogEngelsk
TidsskriftB J C
Vol/bind114
Udgave nummer5
Sider (fra-til)571-575
ISSN0007-0920
DOI
StatusUdgivet - 1. mar. 2016

Fingeraftryk

Lithium
Case-Control Studies
Confidence Intervals
Colon
Anticarcinogenic Agents
Rectum
Registries
Colorectal Neoplasms
Logistic Models
Odds Ratio
Enzymes
Neoplasms

Citer dette

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title = "Long-term use of lithium and risk of colorectal adenocarcinoma: a nationwide case-control study",
abstract = "BACKGROUND: Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study.METHODS: We used the Danish Cancer Registry to identify all patients diagnosed with incident colorectal adenocarcinoma during 2000-2012 (n=36 248). Using a matched case-control approach, we estimated the association between long-term use (⩾5 years) of lithium and risk of colorectal adenocarcinoma using conditional logistic regression.RESULTS: Long-term use of lithium was similar among cases (0.22{\%}) and controls (0.20{\%}), yielding an odds ratio of 1.13 (95{\%} confidence interval (CI), 0.89-1.43) for colorectal adenocarcinoma. Dose-response, subgroup and other subanalyses returned neutral associations. However, ORs differed for colorectal subsites (proximal colon: 1.01 (95{\%} CI, 0.66-1.55; distal colon: 1.52 (95{\%} CI, 1.05-2.20); and rectum: 0.80 (95{\%} CI, 0.50-1.30).CONCLUSIONS: Lithium use was not associated with an overall increased risk of colorectal adenocarcinoma. The variation by subsite warrants further investigation.",
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Long-term use of lithium and risk of colorectal adenocarcinoma : a nationwide case-control study. / Pottegård, Anton; Ennis, Zandra Nymand; Hallas, Jesper; Jensen, Boye L; Madsen, Kirsten; Friis, Søren.

I: B J C, Bind 114, Nr. 5, 01.03.2016, s. 571-575.

Publikation: Bidrag til tidsskriftLetterForskningpeer review

TY - JOUR

T1 - Long-term use of lithium and risk of colorectal adenocarcinoma

T2 - a nationwide case-control study

AU - Pottegård, Anton

AU - Ennis, Zandra Nymand

AU - Hallas, Jesper

AU - Jensen, Boye L

AU - Madsen, Kirsten

AU - Friis, Søren

PY - 2016/3/1

Y1 - 2016/3/1

N2 - BACKGROUND: Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study.METHODS: We used the Danish Cancer Registry to identify all patients diagnosed with incident colorectal adenocarcinoma during 2000-2012 (n=36 248). Using a matched case-control approach, we estimated the association between long-term use (⩾5 years) of lithium and risk of colorectal adenocarcinoma using conditional logistic regression.RESULTS: Long-term use of lithium was similar among cases (0.22%) and controls (0.20%), yielding an odds ratio of 1.13 (95% confidence interval (CI), 0.89-1.43) for colorectal adenocarcinoma. Dose-response, subgroup and other subanalyses returned neutral associations. However, ORs differed for colorectal subsites (proximal colon: 1.01 (95% CI, 0.66-1.55; distal colon: 1.52 (95% CI, 1.05-2.20); and rectum: 0.80 (95% CI, 0.50-1.30).CONCLUSIONS: Lithium use was not associated with an overall increased risk of colorectal adenocarcinoma. The variation by subsite warrants further investigation.

AB - BACKGROUND: Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study.METHODS: We used the Danish Cancer Registry to identify all patients diagnosed with incident colorectal adenocarcinoma during 2000-2012 (n=36 248). Using a matched case-control approach, we estimated the association between long-term use (⩾5 years) of lithium and risk of colorectal adenocarcinoma using conditional logistic regression.RESULTS: Long-term use of lithium was similar among cases (0.22%) and controls (0.20%), yielding an odds ratio of 1.13 (95% confidence interval (CI), 0.89-1.43) for colorectal adenocarcinoma. Dose-response, subgroup and other subanalyses returned neutral associations. However, ORs differed for colorectal subsites (proximal colon: 1.01 (95% CI, 0.66-1.55; distal colon: 1.52 (95% CI, 1.05-2.20); and rectum: 0.80 (95% CI, 0.50-1.30).CONCLUSIONS: Lithium use was not associated with an overall increased risk of colorectal adenocarcinoma. The variation by subsite warrants further investigation.

U2 - 10.1038/bjc.2016.10

DO - 10.1038/bjc.2016.10

M3 - Letter

C2 - 26867160

VL - 114

SP - 571

EP - 575

JO - B J C

JF - B J C

SN - 0007-0920

IS - 5

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