Long-term mortality in HIV-infected individuals 50 years or older

a nationwide, population-based cohort study

Rebecca Legarth, Magnus G Ahlström, Gitte Kronborg, Carsten S Larsen, Court Pedersen, Gitte Pedersen, Rajesh Mohey, Jan Gerstoft, Niels Obel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Although the prevalence of HIV-infection among individuals ≥ 50 years of age has increased, the impact of HIV-infection on risk of death in this population remains to be established. Our aim was to estimate long-term mortality among HIV-infected individuals who were 50 years or older, when compared to an individually-matched cohort from the background population.

METHODS: Population-based cohort-study including HIV-infected individuals ≥ 50 years, who were alive one year after HIV-diagnosis (n=2,440) and a comparison cohort individually-matched by age and gender extracted from the background population (n=14,588). Cumulative survival was evaluated using Kaplan-Meier method and Mortality Rate Ratios (MRRs) were estimated using Cox Regression Models. Study period 1996-2014.

RESULTS: Estimated median survival time from age 50 years for HIV-infected individuals increased from 11.8 years (95% CI; 10.2-14.5) during 1996-1999 to 22.8 years (20.0-24.2) in 2006-2014. MRR decreased with increasing age from 3.8 (3.1-4.7) for 50-55 years to 1.6 (1.0-2.6) for 75-80 years. In a cohort of well-treated HIV-infected individuals ≥ 50 years without AIDS-defining events or comorbidity at study inclusion (n=517). MRR was 1.7 (1.2-2.3) compared to population controls without comorbidity.

CONCLUSION: Among HIV-infected individuals estimated median survival time from age 50 years has increased by more than 10 years from 1996-1999 to 2006-2014, but is still substantially lower than in the background population. Even among well-treated HIV-infected individuals ≥ 50 years without comorbidity or AIDS-defining events the estimated median survival time remains lower than in the general population.

OriginalsprogEngelsk
TidsskriftJ A I D S
Vol/bind71
Udgave nummer2
Sider (fra-til)213-218
ISSN1525-4135
DOI
StatusUdgivet - 2016

Fingeraftryk

Cohort Studies
HIV
Population
Comorbidity
Acquired Immunodeficiency Syndrome
Population Control
Proportional Hazards Models

Citer dette

Legarth, Rebecca ; Ahlström, Magnus G ; Kronborg, Gitte ; Larsen, Carsten S ; Pedersen, Court ; Pedersen, Gitte ; Mohey, Rajesh ; Gerstoft, Jan ; Obel, Niels. / Long-term mortality in HIV-infected individuals 50 years or older : a nationwide, population-based cohort study. I: J A I D S. 2016 ; Bind 71, Nr. 2. s. 213-218.
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title = "Long-term mortality in HIV-infected individuals 50 years or older: a nationwide, population-based cohort study",
abstract = "BACKGROUND: Although the prevalence of HIV-infection among individuals ≥ 50 years of age has increased, the impact of HIV-infection on risk of death in this population remains to be established. Our aim was to estimate long-term mortality among HIV-infected individuals who were 50 years or older, when compared to an individually-matched cohort from the background population.METHODS: Population-based cohort-study including HIV-infected individuals ≥ 50 years, who were alive one year after HIV-diagnosis (n=2,440) and a comparison cohort individually-matched by age and gender extracted from the background population (n=14,588). Cumulative survival was evaluated using Kaplan-Meier method and Mortality Rate Ratios (MRRs) were estimated using Cox Regression Models. Study period 1996-2014.RESULTS: Estimated median survival time from age 50 years for HIV-infected individuals increased from 11.8 years (95{\%} CI; 10.2-14.5) during 1996-1999 to 22.8 years (20.0-24.2) in 2006-2014. MRR decreased with increasing age from 3.8 (3.1-4.7) for 50-55 years to 1.6 (1.0-2.6) for 75-80 years. In a cohort of well-treated HIV-infected individuals ≥ 50 years without AIDS-defining events or comorbidity at study inclusion (n=517). MRR was 1.7 (1.2-2.3) compared to population controls without comorbidity.CONCLUSION: Among HIV-infected individuals estimated median survival time from age 50 years has increased by more than 10 years from 1996-1999 to 2006-2014, but is still substantially lower than in the background population. Even among well-treated HIV-infected individuals ≥ 50 years without comorbidity or AIDS-defining events the estimated median survival time remains lower than in the general population.",
author = "Rebecca Legarth and Ahlstr{\"o}m, {Magnus G} and Gitte Kronborg and Larsen, {Carsten S} and Court Pedersen and Gitte Pedersen and Rajesh Mohey and Jan Gerstoft and Niels Obel",
year = "2016",
doi = "10.1097/QAI.0000000000000825",
language = "English",
volume = "71",
pages = "213--218",
journal = "J A I D S",
issn = "1525-4135",
publisher = "Lippincott Williams & Wilkins",
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Legarth, R, Ahlström, MG, Kronborg, G, Larsen, CS, Pedersen, C, Pedersen, G, Mohey, R, Gerstoft, J & Obel, N 2016, 'Long-term mortality in HIV-infected individuals 50 years or older: a nationwide, population-based cohort study', J A I D S, bind 71, nr. 2, s. 213-218. https://doi.org/10.1097/QAI.0000000000000825

Long-term mortality in HIV-infected individuals 50 years or older : a nationwide, population-based cohort study. / Legarth, Rebecca; Ahlström, Magnus G; Kronborg, Gitte; Larsen, Carsten S; Pedersen, Court; Pedersen, Gitte; Mohey, Rajesh; Gerstoft, Jan; Obel, Niels.

I: J A I D S, Bind 71, Nr. 2, 2016, s. 213-218.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Long-term mortality in HIV-infected individuals 50 years or older

T2 - a nationwide, population-based cohort study

AU - Legarth, Rebecca

AU - Ahlström, Magnus G

AU - Kronborg, Gitte

AU - Larsen, Carsten S

AU - Pedersen, Court

AU - Pedersen, Gitte

AU - Mohey, Rajesh

AU - Gerstoft, Jan

AU - Obel, Niels

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Although the prevalence of HIV-infection among individuals ≥ 50 years of age has increased, the impact of HIV-infection on risk of death in this population remains to be established. Our aim was to estimate long-term mortality among HIV-infected individuals who were 50 years or older, when compared to an individually-matched cohort from the background population.METHODS: Population-based cohort-study including HIV-infected individuals ≥ 50 years, who were alive one year after HIV-diagnosis (n=2,440) and a comparison cohort individually-matched by age and gender extracted from the background population (n=14,588). Cumulative survival was evaluated using Kaplan-Meier method and Mortality Rate Ratios (MRRs) were estimated using Cox Regression Models. Study period 1996-2014.RESULTS: Estimated median survival time from age 50 years for HIV-infected individuals increased from 11.8 years (95% CI; 10.2-14.5) during 1996-1999 to 22.8 years (20.0-24.2) in 2006-2014. MRR decreased with increasing age from 3.8 (3.1-4.7) for 50-55 years to 1.6 (1.0-2.6) for 75-80 years. In a cohort of well-treated HIV-infected individuals ≥ 50 years without AIDS-defining events or comorbidity at study inclusion (n=517). MRR was 1.7 (1.2-2.3) compared to population controls without comorbidity.CONCLUSION: Among HIV-infected individuals estimated median survival time from age 50 years has increased by more than 10 years from 1996-1999 to 2006-2014, but is still substantially lower than in the background population. Even among well-treated HIV-infected individuals ≥ 50 years without comorbidity or AIDS-defining events the estimated median survival time remains lower than in the general population.

AB - BACKGROUND: Although the prevalence of HIV-infection among individuals ≥ 50 years of age has increased, the impact of HIV-infection on risk of death in this population remains to be established. Our aim was to estimate long-term mortality among HIV-infected individuals who were 50 years or older, when compared to an individually-matched cohort from the background population.METHODS: Population-based cohort-study including HIV-infected individuals ≥ 50 years, who were alive one year after HIV-diagnosis (n=2,440) and a comparison cohort individually-matched by age and gender extracted from the background population (n=14,588). Cumulative survival was evaluated using Kaplan-Meier method and Mortality Rate Ratios (MRRs) were estimated using Cox Regression Models. Study period 1996-2014.RESULTS: Estimated median survival time from age 50 years for HIV-infected individuals increased from 11.8 years (95% CI; 10.2-14.5) during 1996-1999 to 22.8 years (20.0-24.2) in 2006-2014. MRR decreased with increasing age from 3.8 (3.1-4.7) for 50-55 years to 1.6 (1.0-2.6) for 75-80 years. In a cohort of well-treated HIV-infected individuals ≥ 50 years without AIDS-defining events or comorbidity at study inclusion (n=517). MRR was 1.7 (1.2-2.3) compared to population controls without comorbidity.CONCLUSION: Among HIV-infected individuals estimated median survival time from age 50 years has increased by more than 10 years from 1996-1999 to 2006-2014, but is still substantially lower than in the background population. Even among well-treated HIV-infected individuals ≥ 50 years without comorbidity or AIDS-defining events the estimated median survival time remains lower than in the general population.

U2 - 10.1097/QAI.0000000000000825

DO - 10.1097/QAI.0000000000000825

M3 - Journal article

VL - 71

SP - 213

EP - 218

JO - J A I D S

JF - J A I D S

SN - 1525-4135

IS - 2

ER -