Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer

Rina So; Zorana J. Andersen; Jie Chen; Massimo Stafoggia; Kees de Hoogh; Klea Katsouyanni; Danielle Vienneau; Sophia Rodopoulou; Evangelia Samoli; Youn Hee Lim; Jeanette T. Jørgensen; Heresh Amini; Tom Cole-Hunter; Seyed Mahmood Taghavi Shahri; Matija Maric; Marie Bergmann; Shuo Liu; Shadi Azam; Steffen Loft; Rudi G.J. Westendorp; Laust H. Mortensen; Mariska Bauwelinck; Jochem O. Klompmaker; Richard Atkinson; Nicole A.H. Janssen; Bente Oftedal; Matteo Renzi; Francesco Forastiere; Maciek Strak; Lau C. Thygesen; Bert Brunekreef; Gerard Hoek; Amar J. Mehta

doi:10.1016/j.envint.2022.107241

Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer

Rina So^*
, Zorana J. Andersen
, Jie Chen
, Massimo Stafoggia
, Kees de Hoogh
, Klea Katsouyanni
, Danielle Vienneau
, Sophia Rodopoulou
, Evangelia Samoli
, Youn Hee Lim
, Jeanette T. Jørgensen
, Heresh Amini
, Tom Cole-Hunter
, Seyed Mahmood Taghavi Shahri
, Matija Maric
, Marie Bergmann
, Shuo Liu
, Shadi Azam
, Steffen Loft
, Rudi G.J. Westendorp

Laust H. Mortensen, Mariska Bauwelinck, Jochem O. Klompmaker, Richard Atkinson, Nicole A.H. Janssen, Bente Oftedal, Matteo Renzi, Francesco Forastiere, Maciek Strak, Lau C. Thygesen, Bert Brunekreef, Gerard Hoek, Amar J. Mehta

^*Kontaktforfatter

Statens Institut for Folkesundhed

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Background: The association between long-term exposure to air pollution and mortality from cardiorespiratory diseases is well established, yet the evidence for other diseases remains limited. Objectives: To examine the associations of long-term exposure to air pollution with mortality from diabetes, dementia, psychiatric disorders, chronic kidney disease (CKD), asthma, acute lower respiratory infection (ALRI), as well as mortality from all-natural and cardiorespiratory causes in the Danish nationwide administrative cohort. Methods: We followed all residents aged ≥ 30 years (3,083,227) in Denmark from 1 January 2000 until 31 December 2017. Annual mean concentrations of fine particulate matter (PM_2.5), nitrogen dioxide (NO₂), black carbon (BC), and ozone (warm season) were estimated using European-wide hybrid land-use regression models (100 m × 100 m) and assigned to baseline residential addresses. We used Cox proportional hazard models to evaluate the association between air pollution and mortality, accounting for demographic and socioeconomic factors. We additionally applied indirect adjustment for smoking and body mass index (BMI). Results: During 47,023,454 person-years of follow-up, 803,881 people died from natural causes. Long-term exposure to PM_2.5 (mean: 12.4 µg/m³), NO₂ (20.3 µg/m³), and/or BC (1.0 × 10^-5/m) was statistically significantly associated with all studied mortality outcomes except CKD. A 5 µg/m³ increase in PM_2.5 was associated with higher mortality from all-natural causes (hazard ratio 1.11; 95% confidence interval 1.09–1.13), cardiovascular disease (1.09; 1.07–1.12), respiratory disease (1.11; 1.07–1.15), lung cancer (1.19; 1.15–1.24), diabetes (1.10; 1.04–1.16), dementia (1.05; 1.00–1.10), psychiatric disorders (1.38; 1.27–1.50), asthma (1.13; 0.94–1.36), and ALRI (1.14; 1.09–1.20). Associations with long-term exposure to ozone (mean: 80.2 µg/m³) were generally negative but became significantly positive for several endpoints in two-pollutant models. Generally, associations were attenuated but remained significant after indirect adjustment for smoking and BMI. Conclusion: Long-term exposure to PM_2.5, NO₂, and/or BC in Denmark were associated with mortality beyond cardiorespiratory diseases, including diabetes, dementia, psychiatric disorders, asthma, and ALRI.

Originalsprog	Engelsk
Artikelnummer	107241
Tidsskrift	Environment International
Vol/bind	164
ISSN	0160-4120
DOI	https://doi.org/10.1016/j.envint.2022.107241
Status	Udgivet - jun. 2022

Bibliografisk note

Funding Information:
This work was supported by funding from HEI Research Agreement (#4954-RFA14-3/16-5-3), jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201) and certain motor vehicle and engine manufacturers, and by the Novo Nordisk Foundation Challenge Programme: Harnessing the Power of Big Data to Address the Societal Challenge of Aging (#NNF17OC0027812). The funders had no role in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; and the decision to submit the manuscript for publication

Funding Information:
The research described in this article was conducted under contract with the Health Effects Institute (HEI), an organization jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201 ) and certain motor vehicle and engine manufacturers. The contents of this article do not necessarily reflect the views of HEI or its sponsors, nor do they necessarily reflect the views and policies of the EPA or motor vehicle and engine manufacturers.

Publisher Copyright:
© 2022 The Authors

Finansiering

This work was supported by funding from HEI Research Agreement (#4954-RFA14-3/16-5-3), jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201) and certain motor vehicle and engine manufacturers, and by the Novo Nordisk Foundation Challenge Programme: Harnessing the Power of Big Data to Address the Societal Challenge of Aging (#NNF17OC0027812). The funders had no role in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; and the decision to submit the manuscript for publication The research described in this article was conducted under contract with the Health Effects Institute (HEI), an organization jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201 ) and certain motor vehicle and engine manufacturers. The contents of this article do not necessarily reflect the views of HEI or its sponsors, nor do they necessarily reflect the views and policies of the EPA or motor vehicle and engine manufacturers.

Dokumenter og links

10.1016/j.envint.2022.107241Licens: CC BY-NC-ND

Open Access VersionForlagets udgivne version, 1,49 MBLicens: CC BY-NC-ND

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

So, R., Andersen, Z. J., Chen, J., Stafoggia, M., de Hoogh, K., Katsouyanni, K., Vienneau, D., Rodopoulou, S., Samoli, E., Lim, Y. H., Jørgensen, J. T., Amini, H., Cole-Hunter, T., Mahmood Taghavi Shahri, S., Maric, M., Bergmann, M., Liu, S., Azam, S., Loft, S., ... Mehta, A. J. (2022). Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer. Environment International, 164, Artikel 107241. https://doi.org/10.1016/j.envint.2022.107241

@article{56c489da1c3c41e3b7ef4546f3c7b782,

title = "Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer",

abstract = "Background: The association between long-term exposure to air pollution and mortality from cardiorespiratory diseases is well established, yet the evidence for other diseases remains limited. Objectives: To examine the associations of long-term exposure to air pollution with mortality from diabetes, dementia, psychiatric disorders, chronic kidney disease (CKD), asthma, acute lower respiratory infection (ALRI), as well as mortality from all-natural and cardiorespiratory causes in the Danish nationwide administrative cohort. Methods: We followed all residents aged ≥ 30 years (3,083,227) in Denmark from 1 January 2000 until 31 December 2017. Annual mean concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (warm season) were estimated using European-wide hybrid land-use regression models (100 m × 100 m) and assigned to baseline residential addresses. We used Cox proportional hazard models to evaluate the association between air pollution and mortality, accounting for demographic and socioeconomic factors. We additionally applied indirect adjustment for smoking and body mass index (BMI). Results: During 47,023,454 person-years of follow-up, 803,881 people died from natural causes. Long-term exposure to PM2.5 (mean: 12.4 µg/m3), NO2 (20.3 µg/m3), and/or BC (1.0 × 10-5/m) was statistically significantly associated with all studied mortality outcomes except CKD. A 5 µg/m3 increase in PM2.5 was associated with higher mortality from all-natural causes (hazard ratio 1.11; 95\% confidence interval 1.09–1.13), cardiovascular disease (1.09; 1.07–1.12), respiratory disease (1.11; 1.07–1.15), lung cancer (1.19; 1.15–1.24), diabetes (1.10; 1.04–1.16), dementia (1.05; 1.00–1.10), psychiatric disorders (1.38; 1.27–1.50), asthma (1.13; 0.94–1.36), and ALRI (1.14; 1.09–1.20). Associations with long-term exposure to ozone (mean: 80.2 µg/m3) were generally negative but became significantly positive for several endpoints in two-pollutant models. Generally, associations were attenuated but remained significant after indirect adjustment for smoking and BMI. Conclusion: Long-term exposure to PM2.5, NO2, and/or BC in Denmark were associated with mortality beyond cardiorespiratory diseases, including diabetes, dementia, psychiatric disorders, asthma, and ALRI.",

keywords = "Cardiorespiratory disease, Dementia, Long-term exposure to air pollution, Mortality, Nationwide administrative cohort, Psychiatric disorders",

author = "Rina So and Andersen, \{Zorana J.\} and Jie Chen and Massimo Stafoggia and \{de Hoogh\}, Kees and Klea Katsouyanni and Danielle Vienneau and Sophia Rodopoulou and Evangelia Samoli and Lim, \{Youn Hee\} and J{\o}rgensen, \{Jeanette T.\} and Heresh Amini and Tom Cole-Hunter and \{Mahmood Taghavi Shahri\}, Seyed and Matija Maric and Marie Bergmann and Shuo Liu and Shadi Azam and Steffen Loft and Westendorp, \{Rudi G.J.\} and Mortensen, \{Laust H.\} and Mariska Bauwelinck and Klompmaker, \{Jochem O.\} and Richard Atkinson and Janssen, \{Nicole A.H.\} and Bente Oftedal and Matteo Renzi and Francesco Forastiere and Maciek Strak and Thygesen, \{Lau C.\} and Bert Brunekreef and Gerard Hoek and Mehta, \{Amar J.\}",

note = "Funding Information: This work was supported by funding from HEI Research Agreement (\#4954-RFA14-3/16-5-3), jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201) and certain motor vehicle and engine manufacturers, and by the Novo Nordisk Foundation Challenge Programme: Harnessing the Power of Big Data to Address the Societal Challenge of Aging (\#NNF17OC0027812). The funders had no role in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; and the decision to submit the manuscript for publication Funding Information: The research described in this article was conducted under contract with the Health Effects Institute (HEI), an organization jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201 ) and certain motor vehicle and engine manufacturers. The contents of this article do not necessarily reflect the views of HEI or its sponsors, nor do they necessarily reflect the views and policies of the EPA or motor vehicle and engine manufacturers. Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = jun,

doi = "10.1016/j.envint.2022.107241",

language = "English",

volume = "164",

journal = "Environment International",

issn = "0160-4120",

publisher = "Elsevier",

}

So, R, Andersen, ZJ, Chen, J, Stafoggia, M, de Hoogh, K, Katsouyanni, K, Vienneau, D, Rodopoulou, S, Samoli, E, Lim, YH, Jørgensen, JT, Amini, H, Cole-Hunter, T, Mahmood Taghavi Shahri, S, Maric, M, Bergmann, M, Liu, S, Azam, S, Loft, S, Westendorp, RGJ, Mortensen, LH, Bauwelinck, M, Klompmaker, JO, Atkinson, R, Janssen, NAH, Oftedal, B, Renzi, M, Forastiere, F, Strak, M, Thygesen, LC, Brunekreef, B, Hoek, G & Mehta, AJ 2022, 'Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer', Environment International, bind 164, 107241. https://doi.org/10.1016/j.envint.2022.107241

TY - JOUR

T1 - Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study

T2 - Beyond mortality from cardiopulmonary disease and lung cancer

AU - So, Rina

AU - Andersen, Zorana J.

AU - Chen, Jie

AU - Stafoggia, Massimo

AU - de Hoogh, Kees

AU - Katsouyanni, Klea

AU - Vienneau, Danielle

AU - Rodopoulou, Sophia

AU - Samoli, Evangelia

AU - Lim, Youn Hee

AU - Jørgensen, Jeanette T.

AU - Amini, Heresh

AU - Cole-Hunter, Tom

AU - Mahmood Taghavi Shahri, Seyed

AU - Maric, Matija

AU - Bergmann, Marie

AU - Liu, Shuo

AU - Azam, Shadi

AU - Loft, Steffen

AU - Westendorp, Rudi G.J.

AU - Mortensen, Laust H.

AU - Bauwelinck, Mariska

AU - Klompmaker, Jochem O.

AU - Atkinson, Richard

AU - Janssen, Nicole A.H.

AU - Oftedal, Bente

AU - Renzi, Matteo

AU - Forastiere, Francesco

AU - Strak, Maciek

AU - Thygesen, Lau C.

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Mehta, Amar J.

N1 - Funding Information: This work was supported by funding from HEI Research Agreement (#4954-RFA14-3/16-5-3), jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201) and certain motor vehicle and engine manufacturers, and by the Novo Nordisk Foundation Challenge Programme: Harnessing the Power of Big Data to Address the Societal Challenge of Aging (#NNF17OC0027812). The funders had no role in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; and the decision to submit the manuscript for publication Funding Information: The research described in this article was conducted under contract with the Health Effects Institute (HEI), an organization jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201 ) and certain motor vehicle and engine manufacturers. The contents of this article do not necessarily reflect the views of HEI or its sponsors, nor do they necessarily reflect the views and policies of the EPA or motor vehicle and engine manufacturers. Publisher Copyright: © 2022 The Authors

PY - 2022/6

Y1 - 2022/6

N2 - Background: The association between long-term exposure to air pollution and mortality from cardiorespiratory diseases is well established, yet the evidence for other diseases remains limited. Objectives: To examine the associations of long-term exposure to air pollution with mortality from diabetes, dementia, psychiatric disorders, chronic kidney disease (CKD), asthma, acute lower respiratory infection (ALRI), as well as mortality from all-natural and cardiorespiratory causes in the Danish nationwide administrative cohort. Methods: We followed all residents aged ≥ 30 years (3,083,227) in Denmark from 1 January 2000 until 31 December 2017. Annual mean concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (warm season) were estimated using European-wide hybrid land-use regression models (100 m × 100 m) and assigned to baseline residential addresses. We used Cox proportional hazard models to evaluate the association between air pollution and mortality, accounting for demographic and socioeconomic factors. We additionally applied indirect adjustment for smoking and body mass index (BMI). Results: During 47,023,454 person-years of follow-up, 803,881 people died from natural causes. Long-term exposure to PM2.5 (mean: 12.4 µg/m3), NO2 (20.3 µg/m3), and/or BC (1.0 × 10-5/m) was statistically significantly associated with all studied mortality outcomes except CKD. A 5 µg/m3 increase in PM2.5 was associated with higher mortality from all-natural causes (hazard ratio 1.11; 95% confidence interval 1.09–1.13), cardiovascular disease (1.09; 1.07–1.12), respiratory disease (1.11; 1.07–1.15), lung cancer (1.19; 1.15–1.24), diabetes (1.10; 1.04–1.16), dementia (1.05; 1.00–1.10), psychiatric disorders (1.38; 1.27–1.50), asthma (1.13; 0.94–1.36), and ALRI (1.14; 1.09–1.20). Associations with long-term exposure to ozone (mean: 80.2 µg/m3) were generally negative but became significantly positive for several endpoints in two-pollutant models. Generally, associations were attenuated but remained significant after indirect adjustment for smoking and BMI. Conclusion: Long-term exposure to PM2.5, NO2, and/or BC in Denmark were associated with mortality beyond cardiorespiratory diseases, including diabetes, dementia, psychiatric disorders, asthma, and ALRI.

AB - Background: The association between long-term exposure to air pollution and mortality from cardiorespiratory diseases is well established, yet the evidence for other diseases remains limited. Objectives: To examine the associations of long-term exposure to air pollution with mortality from diabetes, dementia, psychiatric disorders, chronic kidney disease (CKD), asthma, acute lower respiratory infection (ALRI), as well as mortality from all-natural and cardiorespiratory causes in the Danish nationwide administrative cohort. Methods: We followed all residents aged ≥ 30 years (3,083,227) in Denmark from 1 January 2000 until 31 December 2017. Annual mean concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (warm season) were estimated using European-wide hybrid land-use regression models (100 m × 100 m) and assigned to baseline residential addresses. We used Cox proportional hazard models to evaluate the association between air pollution and mortality, accounting for demographic and socioeconomic factors. We additionally applied indirect adjustment for smoking and body mass index (BMI). Results: During 47,023,454 person-years of follow-up, 803,881 people died from natural causes. Long-term exposure to PM2.5 (mean: 12.4 µg/m3), NO2 (20.3 µg/m3), and/or BC (1.0 × 10-5/m) was statistically significantly associated with all studied mortality outcomes except CKD. A 5 µg/m3 increase in PM2.5 was associated with higher mortality from all-natural causes (hazard ratio 1.11; 95% confidence interval 1.09–1.13), cardiovascular disease (1.09; 1.07–1.12), respiratory disease (1.11; 1.07–1.15), lung cancer (1.19; 1.15–1.24), diabetes (1.10; 1.04–1.16), dementia (1.05; 1.00–1.10), psychiatric disorders (1.38; 1.27–1.50), asthma (1.13; 0.94–1.36), and ALRI (1.14; 1.09–1.20). Associations with long-term exposure to ozone (mean: 80.2 µg/m3) were generally negative but became significantly positive for several endpoints in two-pollutant models. Generally, associations were attenuated but remained significant after indirect adjustment for smoking and BMI. Conclusion: Long-term exposure to PM2.5, NO2, and/or BC in Denmark were associated with mortality beyond cardiorespiratory diseases, including diabetes, dementia, psychiatric disorders, asthma, and ALRI.

KW - Cardiorespiratory disease

KW - Dementia

KW - Long-term exposure to air pollution

KW - Mortality

KW - Nationwide administrative cohort

KW - Psychiatric disorders

U2 - 10.1016/j.envint.2022.107241

DO - 10.1016/j.envint.2022.107241

M3 - Journal article

C2 - 35544998

AN - SCOPUS:85129776362

SN - 0160-4120

VL - 164

JO - Environment International

JF - Environment International

M1 - 107241

ER -

Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer

Abstract

Bibliografisk note

Finansiering

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