Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

Johanneke Kleinnijenhuis, Jessica Quintin, Frank Preijers, Christine Stabell Benn, Leo A B Joosten, Cor Jacobs, Joke van Loenhout, Ramnik J Xavier, Peter Aaby, Jos W M van der Meer, Reinout van Crevel, Mihai G Netea

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 months after vaccination. This phenomenon was named 'trained immunity'. In the present study we assessed whether BCG was able to induce long-lasting effects on both trained immunity and heterologous T helper 1 (Th1) and Th17 immune responses 1 year after vaccination. The production of TNFα and IL-1β to mycobacteria or unrelated pathogens was higher after 2 weeks and 3 months postvaccination, but these effects were less pronounced 1 year after vaccination. However, monocytes recovered 1 year after vaccination had an increased expression of pattern recognition receptors such as CD14, Toll-like receptor 4 (TLR4) and mannose receptor, and this correlated with an increase in proinflammatory cytokine production after stimulation with the TLR4 ligand lipopolysaccharide. The heterologous production of Th1 (IFN-γ) and Th17 (IL-17 and IL-22) immune responses to nonmycobacterial stimulation remained strongly elevated even 1 year after BCG vaccination. In conclusion, BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at the level of heterologous Th1/Th17 responses. © 2013 S. Karger AG, Basel.
OriginalsprogEngelsk
TidsskriftJournal of Innate Immunity
Vol/bind37
Udgave nummer9
Sider (fra-til)1041–1045
ISSN1662-811X
DOI
StatusUdgivet - 2013

Fingeraftryk

Toll-Like Receptor 4
Interleukin-17
Epigenomics
Immune System
Ligands
mannose receptor

Citer dette

Kleinnijenhuis, J., Quintin, J., Preijers, F., Benn, C. S., Joosten, L. A. B., Jacobs, C., ... Netea, M. G. (2013). Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity. Journal of Innate Immunity, 37(9), 1041–1045. https://doi.org/10.1159/000355628
Kleinnijenhuis, Johanneke ; Quintin, Jessica ; Preijers, Frank ; Benn, Christine Stabell ; Joosten, Leo A B ; Jacobs, Cor ; van Loenhout, Joke ; Xavier, Ramnik J ; Aaby, Peter ; van der Meer, Jos W M ; van Crevel, Reinout ; Netea, Mihai G. / Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity. I: Journal of Innate Immunity. 2013 ; Bind 37, Nr. 9. s. 1041–1045.
@article{28ee85cf29f7461e89b6c0a6e01d599f,
title = "Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity",
abstract = "We have recently shown that BCG (Bacillus Calmette-Gu{\'e}rin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 months after vaccination. This phenomenon was named 'trained immunity'. In the present study we assessed whether BCG was able to induce long-lasting effects on both trained immunity and heterologous T helper 1 (Th1) and Th17 immune responses 1 year after vaccination. The production of TNFα and IL-1β to mycobacteria or unrelated pathogens was higher after 2 weeks and 3 months postvaccination, but these effects were less pronounced 1 year after vaccination. However, monocytes recovered 1 year after vaccination had an increased expression of pattern recognition receptors such as CD14, Toll-like receptor 4 (TLR4) and mannose receptor, and this correlated with an increase in proinflammatory cytokine production after stimulation with the TLR4 ligand lipopolysaccharide. The heterologous production of Th1 (IFN-γ) and Th17 (IL-17 and IL-22) immune responses to nonmycobacterial stimulation remained strongly elevated even 1 year after BCG vaccination. In conclusion, BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at the level of heterologous Th1/Th17 responses. {\circledC} 2013 S. Karger AG, Basel.",
author = "Johanneke Kleinnijenhuis and Jessica Quintin and Frank Preijers and Benn, {Christine Stabell} and Joosten, {Leo A B} and Cor Jacobs and {van Loenhout}, Joke and Xavier, {Ramnik J} and Peter Aaby and {van der Meer}, {Jos W M} and {van Crevel}, Reinout and Netea, {Mihai G}",
year = "2013",
doi = "10.1159/000355628",
language = "English",
volume = "37",
pages = "1041–1045",
journal = "Journal of Innate Immunity",
issn = "1662-811X",
publisher = "S. Karger AG",
number = "9",

}

Kleinnijenhuis, J, Quintin, J, Preijers, F, Benn, CS, Joosten, LAB, Jacobs, C, van Loenhout, J, Xavier, RJ, Aaby, P, van der Meer, JWM, van Crevel, R & Netea, MG 2013, 'Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity', Journal of Innate Immunity, bind 37, nr. 9, s. 1041–1045. https://doi.org/10.1159/000355628

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity. / Kleinnijenhuis, Johanneke; Quintin, Jessica; Preijers, Frank; Benn, Christine Stabell; Joosten, Leo A B; Jacobs, Cor; van Loenhout, Joke; Xavier, Ramnik J; Aaby, Peter; van der Meer, Jos W M; van Crevel, Reinout; Netea, Mihai G.

I: Journal of Innate Immunity, Bind 37, Nr. 9, 2013, s. 1041–1045.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

AU - Kleinnijenhuis, Johanneke

AU - Quintin, Jessica

AU - Preijers, Frank

AU - Benn, Christine Stabell

AU - Joosten, Leo A B

AU - Jacobs, Cor

AU - van Loenhout, Joke

AU - Xavier, Ramnik J

AU - Aaby, Peter

AU - van der Meer, Jos W M

AU - van Crevel, Reinout

AU - Netea, Mihai G

PY - 2013

Y1 - 2013

N2 - We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 months after vaccination. This phenomenon was named 'trained immunity'. In the present study we assessed whether BCG was able to induce long-lasting effects on both trained immunity and heterologous T helper 1 (Th1) and Th17 immune responses 1 year after vaccination. The production of TNFα and IL-1β to mycobacteria or unrelated pathogens was higher after 2 weeks and 3 months postvaccination, but these effects were less pronounced 1 year after vaccination. However, monocytes recovered 1 year after vaccination had an increased expression of pattern recognition receptors such as CD14, Toll-like receptor 4 (TLR4) and mannose receptor, and this correlated with an increase in proinflammatory cytokine production after stimulation with the TLR4 ligand lipopolysaccharide. The heterologous production of Th1 (IFN-γ) and Th17 (IL-17 and IL-22) immune responses to nonmycobacterial stimulation remained strongly elevated even 1 year after BCG vaccination. In conclusion, BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at the level of heterologous Th1/Th17 responses. © 2013 S. Karger AG, Basel.

AB - We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 months after vaccination. This phenomenon was named 'trained immunity'. In the present study we assessed whether BCG was able to induce long-lasting effects on both trained immunity and heterologous T helper 1 (Th1) and Th17 immune responses 1 year after vaccination. The production of TNFα and IL-1β to mycobacteria or unrelated pathogens was higher after 2 weeks and 3 months postvaccination, but these effects were less pronounced 1 year after vaccination. However, monocytes recovered 1 year after vaccination had an increased expression of pattern recognition receptors such as CD14, Toll-like receptor 4 (TLR4) and mannose receptor, and this correlated with an increase in proinflammatory cytokine production after stimulation with the TLR4 ligand lipopolysaccharide. The heterologous production of Th1 (IFN-γ) and Th17 (IL-17 and IL-22) immune responses to nonmycobacterial stimulation remained strongly elevated even 1 year after BCG vaccination. In conclusion, BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at the level of heterologous Th1/Th17 responses. © 2013 S. Karger AG, Basel.

U2 - 10.1159/000355628

DO - 10.1159/000355628

M3 - Journal article

VL - 37

SP - 1041

EP - 1045

JO - Journal of Innate Immunity

JF - Journal of Innate Immunity

SN - 1662-811X

IS - 9

ER -